Author: Saskia P Hagenaars

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Preprints

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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  • Site-wide: 2,139
  • In genetics: 83
• Year to date:
  • Site-wide: 26,449
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  • Site-wide: 26,449

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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  • Site-wide: 3,452
  • In genetics: 147
• Year to date:
  • Site-wide: 25,701
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  • Site-wide: 25,701

Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

• Downloaded 2,559 times
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  • Site-wide: 4,797
  • In genetics: 224
• Year to date:
  • Site-wide: 62,447
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  • Site-wide: 62,447

Molecular genetic contributions to self-rated health

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  • Site-wide: 5,978
  • In genetics: 291
• Year to date:
  • Site-wide: 51,787
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  • Site-wide: 51,787

GWAS on family history of Alzheimer's disease

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  • Site-wide: 7,057
  • In genetics: 345
• Year to date:
  • Site-wide: 62,512
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  • Site-wide: 62,512

Genetic Prediction of Male Pattern Baldness

• Downloaded 1,780 times
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  • Site-wide: 8,211
  • In genetics: 402
• Year to date:
  • Site-wide: 39,518
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  • Site-wide: 39,518

Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N = 112 151) and 24 GWAS consortia.

• Downloaded 1,775 times
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  • Site-wide: 8,247
  • In genetics: 405
• Year to date:
  • Site-wide: 53,428
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  • Site-wide: 53,428

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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  • Site-wide: 8,821
  • In genetics: 439
• Year to date:
  • Site-wide: 91,910
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  • Site-wide: 91,910

Age differences in brain white matter microstructure in UK Biobank (N = 3,513)

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  • Site-wide: 9,410
  • In neuroscience: 1,021
• Year to date:
  • Site-wide: 53,127
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  • Site-wide: 53,127

Genome-wide association study of over 40,000 bipolar disorder cases provides novel biological insights

• Downloaded 1,557 times
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  • Site-wide: 10,057
  • In psychiatry and clinical psychology: 32
• Year to date:
  • Site-wide: 2,274
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  • Site-wide: 2,274

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

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  • Site-wide: 12,594
  • In genetics: 637
• Year to date:
  • Site-wide: 111,834
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  • Site-wide: 111,834

Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

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  • Site-wide: 15,014
  • In genetics: 773
• Year to date:
  • Site-wide: 70,318
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  • Site-wide: 70,318

Identifying Potential Causal Risk Factors for Self-Harm: A Polygenic Risk Scoring and Mendelian Randomisation Approach

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  • Site-wide: 24,026
  • In epidemiology: 1,301
• Year to date:
  • Site-wide: 20,475
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  • Site-wide: 20,475

Polygenic architecture of human neuroanatomical diversity

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  • Site-wide: 26,509
  • In neuroscience: 3,568
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Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

• Downloaded 724 times
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  • Site-wide: 30,763
  • In genetics: 1,530
• Year to date:
  • Site-wide: 97,812
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  • Site-wide: 97,812

Genetic contributions to self-reported tiredness

• Downloaded 710 times
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  • Site-wide: 31,620
  • In genetics: 1,575
• Year to date:
  • Site-wide: 28,480
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  • Site-wide: 28,480

Atypical depression shares genetic predisposition with immuno-metabolic traits: a population-based study

• Downloaded 686 times
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  • Site-wide: 33,094
  • In genetic and genomic medicine: 95
• Year to date:
  • Site-wide: 17,613
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  • Site-wide: 17,613

Cognitive ability and physical health: a Mendelian randomization study

• Downloaded 605 times
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  • Site-wide: 39,008
  • In genetics: 1,893
• Year to date:
  • Site-wide: 82,130
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  • Site-wide: 82,130

Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank

• Downloaded 564 times
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  • Site-wide: 42,575
  • In genetics: 2,064
• Year to date:
  • Site-wide: 82,298
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  • Site-wide: 82,298

Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts

• Downloaded 524 times
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  • Site-wide: 46,618
  • In psychiatry and clinical psychology: 145
• Year to date:
  • Site-wide: 11,774
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  • Site-wide: 11,774

Polygenic predictors of age-related decline in cognitive ability

• Downloaded 479 times
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  • Site-wide: 51,727
  • In genomics: 4,044
• Year to date:
  • Site-wide: 106,539
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  • Site-wide: 106,539

Genetic contributions to trail making test performance in UK Biobank

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  • Site-wide: 54,692
  • In genetics: 2,598
• Year to date:
  • Site-wide: 108,175
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  • Site-wide: 108,175

Genetic comorbidity between major depression and cardio-metabolic disease, stratified by age at onset of major depression.

• Downloaded 447 times
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  • Site-wide: 55,775
  • In genetics: 2,648
• Year to date:
  • Site-wide: 85,904
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  • Site-wide: 85,904

Using Major Depression Polygenic Risk Scores to Explore the Depressive Symptom Continuum

• Downloaded 440 times
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  • Site-wide: 56,729
  • In genetics: 2,693
• Year to date:
  • Site-wide: 67,435
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  • Site-wide: 67,435

Evaluation of Polygenic Prediction Methodology within a Reference-Standardized Framework

• Downloaded 395 times
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  • Site-wide: 63,319
  • In genomics: 4,588
• Year to date:
  • Site-wide: 22,013
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  • Site-wide: 22,013

Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function

• Downloaded 341 times
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  • Site-wide: 72,137
  • In genetics: 3,371
• Year to date:
  • Site-wide: 106,261
• Since beginning of last month:
  • Site-wide: 106,261

Genetic contributions to health literacy

• Downloaded 334 times
• Download rankings, all-time:
  • Site-wide: 73,427
  • In epidemiology: 3,034
• Year to date:
  • Site-wide: 100,512
• Since beginning of last month:
  • Site-wide: 100,512

Imputed Gene Expression Risk Scores: A Functionally Informed Component of Polygenic Risk

• Downloaded 262 times
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  • Site-wide: 87,753
  • In genomics: 5,543
• Year to date:
  • Site-wide: 15,266
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  • Site-wide: 15,266

Phenotypic Associations and Shared Genetic Etiology between Bipolar Disorder and Cardiometabolic Traits

• Downloaded 238 times
• Download rankings, all-time:
  • Site-wide: 92,800
  • In psychiatry and clinical psychology: 329
• Year to date:
  • Site-wide: 50,864
• Since beginning of last month:
  • Site-wide: 50,864

Examining the association between family status and depression in the UK Biobank

• Downloaded 127 times
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  • Site-wide: 115,659
  • In epidemiology: 4,679
• Year to date:
  • Site-wide: 68,778
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  • Site-wide: 68,778