Author: Alison M Goate

Downloads per author, site-wide

Preprints

Integration of Alzheimer’s disease genetics and myeloid genomics reveals novel disease risk mechanisms

• Downloaded 3,074 times
• Download rankings, all-time:
  • Site-wide: 3,733
  • In genomics: 437
• Year to date:
  • Site-wide: 3,958
• Since beginning of last month:
  • Site-wide: 5,132

Cholesterol and matrisome pathways dysregulated in human APOE ε4 glia

• Downloaded 2,286 times
• Download rankings, all-time:
  • Site-wide: 5,742
  • In neuroscience: 549
• Year to date:
  • Site-wide: 6,841
• Since beginning of last month:
  • Site-wide: 5,141

GWAS on family history of Alzheimer's disease

• Downloaded 1,972 times
• Download rankings, all-time:
  • Site-wide: 7,092
  • In genetics: 345
• Year to date:
  • Site-wide: 58,169
• Since beginning of last month:
  • Site-wide: 31,522

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

• Downloaded 1,867 times
• Download rankings, all-time:
  • Site-wide: 7,709
  • In genetics: 369
• Year to date:
  • Site-wide: 62,575
• Since beginning of last month:
  • Site-wide: 60,428

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

• Downloaded 1,826 times
• Download rankings, all-time:
  • Site-wide: 7,962
  • In neuroscience: 837
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

Precision genome-editing with CRISPR/Cas9 in human induced pluripotent stem cells

• Downloaded 1,452 times
• Download rankings, all-time:
  • Site-wide: 11,226
  • In genetics: 557
• Year to date:
  • Site-wide: 44,166
• Since beginning of last month:
  • Site-wide: 36,466

Association between alcohol consumption and Alzheimer’s disease: A Mendelian randomization Study

• Downloaded 1,433 times
• Download rankings, all-time:
  • Site-wide: 11,459
  • In genetics: 571
• Year to date:
  • Site-wide: 29,424
• Since beginning of last month:
  • Site-wide: 22,648

An Efficient Platform For Astrocyte Differentiation From Human Induced Pluripotent Stem Cells

• Downloaded 1,321 times
• Download rankings, all-time:
  • Site-wide: 12,938
  • In neuroscience: 1,517
• Year to date:
  • Site-wide: 41,830
• Since beginning of last month:
  • Site-wide: 44,468

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into the complex genetic architecture

• Downloaded 1,001 times
• Download rankings, all-time:
  • Site-wide: 19,674
  • In genomics: 2,007
• Year to date:
  • Site-wide: 6,780
• Since beginning of last month:
  • Site-wide: 3,811

Causal associations between potentially modifiable risk factors and the Alzheimer's phenome: A Mendelian randomization study

• Downloaded 983 times
• Download rankings, all-time:
  • Site-wide: 20,159
  • In genetics: 1,001
• Year to date:
  • Site-wide: 24,311
• Since beginning of last month:
  • Site-wide: 25,049

Evaluation of gene-based family-based methods to detect novel genes associated with familial late onset Alzheimer disease

• Downloaded 820 times
• Download rankings, all-time:
  • Site-wide: 26,090
  • In genetics: 1,296
• Year to date:
  • Site-wide: 36,648
• Since beginning of last month:
  • Site-wide: 25,553

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

• Downloaded 633 times
• Download rankings, all-time:
  • Site-wide: 37,154
  • In genetics: 1,813
• Year to date:
  • Site-wide: 14,527
• Since beginning of last month:
  • Site-wide: 5,721

Cell-type specific in vitro gene expression profiling of stem-cell derived neural models

• Downloaded 612 times
• Download rankings, all-time:
  • Site-wide: 38,844
  • In molecular biology: 1,105
• Year to date:
  • Site-wide: 13,276
• Since beginning of last month:
  • Site-wide: 9,668

Polygenic Risk Score of Sporadic Late Onset Alzheimer Disease Reveals a Shared Architecture with the Familial and Early Onset Forms

• Downloaded 555 times
• Download rankings, all-time:
  • Site-wide: 43,893
  • In genetics: 2,111
• Year to date:
  • Site-wide: 95,835
• Since beginning of last month:
  • Site-wide: 60,462

Discordant transcriptional signatures of mitochondrial genes in Parkinson's disease human myeloid cells

• Downloaded 458 times
• Download rankings, all-time:
  • Site-wide: 54,828
  • In neuroscience: 8,226
• Year to date:
  • Site-wide: 20,250
• Since beginning of last month:
  • Site-wide: 19,292

Effect of Polygenic Risk Score on Alzheimer's Disease Risk Depends on Age and APOE4 Status

• Downloaded 442 times
• Download rankings, all-time:
  • Site-wide: 56,939
  • In genetic and genomic medicine: 166
• Year to date:
  • Site-wide: 42,913
• Since beginning of last month:
  • Site-wide: 72,844

A globally diverse reference alignment and panel for imputation of mitochondrial DNA variants

• Downloaded 428 times
• Download rankings, all-time:
  • Site-wide: 58,753
  • In genomics: 4,388
• Year to date:
  • Site-wide: 35,022
• Since beginning of last month:
  • Site-wide: 51,675

17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson's disease and progressive supranuclear palsy converge on altered glial regulation

• Downloaded 397 times
• Download rankings, all-time:
  • Site-wide: 63,520
  • In neuroscience: 9,672
• Year to date:
  • Site-wide: 38,731
• Since beginning of last month:
  • Site-wide: 22,453

Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism

• Downloaded 315 times
• Download rankings, all-time:
  • Site-wide: 77,591
  • In neuroscience: 11,977
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

Mendelian randomization indicates that TNF is not causally associated with Alzheimer's disease

• Downloaded 307 times
• Download rankings, all-time:
  • Site-wide: 79,102
  • In genetics: 3,659
• Year to date:
  • Site-wide: 111,730
• Since beginning of last month:
  • Site-wide: 65,331

Glutamatergic dysfunction precedes neuron loss in cerebral organoids with MAPT mutation.

• Downloaded 274 times
• Download rankings, all-time:
  • Site-wide: 85,678
  • In neuroscience: 13,325
• Year to date:
  • Site-wide: 2,891
• Since beginning of last month:
  • Site-wide: 816

Allele-Specific Expression and High-Throughput Reporter Assay Reveal Functional Variants in Human Brains with Alcohol Use Disorders

• Downloaded 262 times
• Download rankings, all-time:
  • Site-wide: 88,371
  • In neuroscience: 13,764
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

Mitonuclear interactions influence Alzheimer's disease risk

• Downloaded 258 times
• Download rankings, all-time:
  • Site-wide: 89,415
  • In genetics: 4,087
• Year to date:
  • Site-wide: 98,628
• Since beginning of last month:
  • Site-wide: 97,509

Multi-omics integration analysis identifies novel genes for alcoholism with potential link to neurodegenerative diseases

• Downloaded 235 times
• Download rankings, all-time:
  • Site-wide: 94,289
  • In genomics: 5,783
• Year to date:
  • Site-wide: 26,196
• Since beginning of last month:
  • Site-wide: 35,297

Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder

• Downloaded 198 times
• Download rankings, all-time:
  • Site-wide: 102,327
  • In genetic and genomic medicine: 396
• Year to date:
  • Site-wide: 53,164
• Since beginning of last month:
  • Site-wide: 47,405

Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population

• Downloaded 166 times
• Download rankings, all-time:
  • Site-wide: 108,786
  • In genetic and genomic medicine: 450
• Year to date:
  • Site-wide: 68,950
• Since beginning of last month:
  • Site-wide: 56,785