Author: Tõnu Esko

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Preprints

Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19

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Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

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  • Site-wide: 3,265
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Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

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Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

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  • Site-wide: 6,102
  • In genetics: 287
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Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

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  • Site-wide: 6,866
  • In psychiatry and clinical psychology: 23
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  • Site-wide: 1,394
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  • Site-wide: 790

Cell specific eQTL analysis without sorting cells

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  • Site-wide: 7,445
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A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 8,833
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PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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  • Site-wide: 9,896
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Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

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  • Site-wide: 11,717
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  • Site-wide: 79,536

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

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  • Site-wide: 15,262
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Haplotype sharing provides insights into fine-scale population history and disease in Finland

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  • Site-wide: 17,800
  • In genetics: 872
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  • Site-wide: 66,193
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  • Site-wide: 53,305

Mega-analysis of 31,396 individuals from 6 countries uncovers strong gene-environment interaction for human fertility

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  • Site-wide: 20,098
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  • Site-wide: 94,122
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  • Site-wide: 96,538

An epigenome-wide association study of educational attainment (n = 10,767)

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Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

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Functional and evolutionary impact of polymorphic inversions in the human genome

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  • Site-wide: 31,403
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Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

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  • In genetics: 1,633
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Polygenic prediction of breast cancer: comparison of genetic predictors and implications for screening

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  • Site-wide: 51,162
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Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

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  • Site-wide: 52,113
  • In genomics: 4,039
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Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

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  • Site-wide: 104,957
  • In genomics: 6,136
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