Author: Daniel Levy

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Preprints

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

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  • Site-wide: 993
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Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 3,747
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Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

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Novel genetic determinants of telomere length from a trans-ethnic analysis of 109,122 whole genome sequences in TOPMed

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  • Site-wide: 13,045
  • In genetics: 660
• Year to date:
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Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

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  • In genomics: 1,461
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Genome-wide Association Study Of Plasma Proteins Identifies Putatively Causal Genes, Proteins, And Pathways For Cardiovascular Disease

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  • In epidemiology: 906
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Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

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  • Site-wide: 15,229
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GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

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  • In genetics: 1,310
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Mitochondrial DNA Copy Number (mtDNA-CN) Can Influence Mortality and Cardiovascular Disease via Methylation of Nuclear DNA CpGs

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  • In genomics: 2,577
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Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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  • In genomics: 2,731
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Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

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  • Site-wide: 39,704
  • In genetics: 1,920
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  • Site-wide: 68,405
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  • Site-wide: 62,849

Nanoscale architecture of a VAP-A-OSBP tethering complex at membrane contact site

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  • In cell biology: 2,383
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Genetically independent phenotype analysis identifies LPA and VCAM1 as drug targets for human ageing

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  • In genomics: 4,360
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A Mechanism for Severity of Disease in Older Patients with COVID-19: The Nexus between Telomere Length and Lymphopenia

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  • In infectious diseases: 2,829
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Novel DNA methylation sites of glucose and insulin homeostasis: an integrative cross-omics analysis

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  • Site-wide: 72,210
  • In genomics: 4,984
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Integrative Genomic Analysis and Functional Studies Reveal GP5, GRN, MPO and MCAM as Causal Protein Biomarkers for Platelet Traits

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Transcriptome-wide Association Study of Circulating IgE Levels Identifies Novel Targets for Asthma and Allergic Diseases

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  • Site-wide: 77,535
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Association of mitochondrial DNA copy number with cardiometabolic diseases in a large cross-sectional study of multiple ancestries

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  • Site-wide: 85,287
  • In epidemiology: 3,491
• Year to date:
  • Site-wide: 25,935
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Integrative Genomic Analysis Identifies the Soluble Receptor for Advanced Glycation End Products as Putatively Causal for Rheumatoid Arthritis

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  • Site-wide: 89,683
  • In rheumatology: 63
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Validation and characterization of a DNA methylation alcohol biomarker across the life course

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  • Site-wide: 95,018
  • In epidemiology: 3,831
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  • Site-wide: 122,627
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Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

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  • Site-wide: 102,161
  • In genomics: 6,025
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  • Site-wide: 101,479
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Transcriptional survey of peripheral blood links lower oxygen saturation during sleep with reduced expressions of CD1D and RAB20 that is reversed by CPAP therapy

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  • Site-wide: 106,785
  • In genetic and genomic medicine: 436
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  • Site-wide: 91,435

Cardiovascular Disease Related Proteomic Biomarkers of Alcohol Consumption

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  • Site-wide: 117,853
  • In bioinformatics: 9,617
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Presence and Transmission of Mitochondrial Heteroplasmic Mutations in Human Populations of European and African Ancestry

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  • In genetics: 5,098
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  • Site-wide: 92,344