Author: André G. Uitterlinden

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

• Downloaded 9,364 times
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  • Site-wide: 818
  • In genetics: 25
• Year to date:
  • Site-wide: 23,229
• Since beginning of last month:
  • Site-wide: 26,057

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,073 times
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  • Site-wide: 3,748
  • In genetics: 166
• Year to date:
  • Site-wide: 35,226
• Since beginning of last month:
  • Site-wide: 37,020

Genome-wide association study identifies 48 common genetic variants associated with handedness

• Downloaded 2,526 times
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  • Site-wide: 4,952
  • In genetics: 229
• Year to date:
  • Site-wide: 17,531
• Since beginning of last month:
  • Site-wide: 18,013

Cell specific eQTL analysis without sorting cells

• Downloaded 1,996 times
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  • Site-wide: 6,972
  • In genetics: 340
• Year to date:
  • Site-wide: 95,108
• Since beginning of last month:
  • Site-wide: 79,518

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,826 times
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  • Site-wide: 7,975
  • In genetics: 387
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

• Downloaded 1,704 times
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  • Site-wide: 8,904
  • In genetics: 440
• Year to date:
  • Site-wide: 57,793
• Since beginning of last month:
  • Site-wide: 57,915

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

• Downloaded 1,700 times
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  • Site-wide: 8,940
  • In genetics: 443
• Year to date:
  • Site-wide: 98,713
• Since beginning of last month:
  • Site-wide: None

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,637 times
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  • Site-wide: 9,460
  • In genetics: 464
• Year to date:
  • Site-wide: 80,730
• Since beginning of last month:
  • Site-wide: 79,924

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

• Downloaded 1,406 times
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  • Site-wide: 11,825
  • In genetics: 593
• Year to date:
  • Site-wide: 27,600
• Since beginning of last month:
  • Site-wide: 19,051

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

• Downloaded 1,401 times
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  • Site-wide: 11,886
  • In genetics: 597
• Year to date:
  • Site-wide: 86,160
• Since beginning of last month:
  • Site-wide: 87,047

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

• Downloaded 1,288 times
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  • Site-wide: 13,484
  • In genomics: 1,461
• Year to date:
  • Site-wide: 16,066
• Since beginning of last month:
  • Site-wide: 12,997

A high-quality reference panel reveals the complexity and distribution of structural genome changes in a human population

• Downloaded 1,275 times
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  • Site-wide: 13,694
  • In genetics: 696
• Year to date:
  • Site-wide: 61,877
• Since beginning of last month:
  • Site-wide: 64,192

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,240 times
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  • Site-wide: 14,279
  • In genomics: 1,515
• Year to date:
  • Site-wide: 58,193
• Since beginning of last month:
  • Site-wide: 49,066

Large-Scale Genome-Wide Meta Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria.

• Downloaded 1,054 times
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  • Site-wide: 18,221
  • In genetics: 915
• Year to date:
  • Site-wide: 69,028
• Since beginning of last month:
  • Site-wide: 40,847

An epigenome-wide association study of educational attainment (n = 10,767)

• Downloaded 984 times
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  • Site-wide: 20,167
  • In genetics: 999
• Year to date:
  • Site-wide: 48,417
• Since beginning of last month:
  • Site-wide: 42,540

Meta-GWAS Accuracy and Power (MetaGAP) calculator shows that hiding heritability is partially due to imperfect genetic correlations across studies

• Downloaded 960 times
• Download rankings, all-time:
  • Site-wide: 20,885
  • In genetics: 1,028
• Year to date:
  • Site-wide: 69,770
• Since beginning of last month:
  • Site-wide: 37,129

Genetic Association Study of Childhood Aggression across raters, instruments and age

• Downloaded 843 times
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  • Site-wide: 25,174
  • In genomics: 2,416
• Year to date:
  • Site-wide: 14,625
• Since beginning of last month:
  • Site-wide: 6,667

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

• Downloaded 773 times
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  • Site-wide: 28,364
  • In genetics: 1,411
• Year to date:
  • Site-wide: 49,558
• Since beginning of last month:
  • Site-wide: 52,608

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 747 times
• Download rankings, all-time:
  • Site-wide: 29,803
  • In genomics: 2,727
• Year to date:
  • Site-wide: 70,224
• Since beginning of last month:
  • Site-wide: 63,333

Novel genetic loci affecting facial shape variation in humans

• Downloaded 672 times
• Download rankings, all-time:
  • Site-wide: 34,429
  • In genomics: 3,027
• Year to date:
  • Site-wide: 69,539
• Since beginning of last month:
  • Site-wide: 78,812

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 602 times
• Download rankings, all-time:
  • Site-wide: 39,633
  • In genetic and genomic medicine: 113
• Year to date:
  • Site-wide: 8,328
• Since beginning of last month:
  • Site-wide: 12,888

Multiethnic Meta-analysis Identifies New Loci for Pulmonary Function

• Downloaded 597 times
• Download rankings, all-time:
  • Site-wide: 40,101
  • In genetics: 1,938
• Year to date:
  • Site-wide: 113,772
• Since beginning of last month:
  • Site-wide: None

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 501 times
• Download rankings, all-time:
  • Site-wide: 49,627
  • In genomics: 3,928
• Year to date:
  • Site-wide: 107,649
• Since beginning of last month:
  • Site-wide: 93,029

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 475 times
• Download rankings, all-time:
  • Site-wide: 52,793
  • In genetics: 2,509
• Year to date:
  • Site-wide: 85,991
• Since beginning of last month:
  • Site-wide: 73,630

Novel DNA methylation sites of glucose and insulin homeostasis: an integrative cross-omics analysis

• Downloaded 344 times
• Download rankings, all-time:
  • Site-wide: 72,335
  • In genomics: 4,984
• Year to date:
  • Site-wide: 122,824
• Since beginning of last month:
  • Site-wide: None

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

• Downloaded 264 times
• Download rankings, all-time:
  • Site-wide: 88,105
  • In genetics: 4,041
• Year to date:
  • Site-wide: 109,005
• Since beginning of last month:
  • Site-wide: 75,978

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 199 times
• Download rankings, all-time:
  • Site-wide: 102,155
  • In genomics: 6,027
• Year to date:
  • Site-wide: 102,847
• Since beginning of last month:
  • Site-wide: 101,181