Author: Timothy Spector

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Preprints

Loss of smell and taste in combination with other symptoms is a strong predictor of COVID-19 infection

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  • Site-wide: 480
  • In epidemiology: 73
• Year to date:
  • Site-wide: 1,153
• Since beginning of last month:
  • Site-wide: 1,051

Self-reported symptoms of covid-19 including symptoms most predictive of SARS-CoV-2 infection, are heritable

• Downloaded 11,342 times
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  • Site-wide: 628
  • In genetic and genomic medicine: 3
• Year to date:
  • Site-wide: 3,052
• Since beginning of last month:
  • Site-wide: 5,345

Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use

• Downloaded 8,606 times
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  • Site-wide: 916
  • In genetics: 27
• Year to date:
  • Site-wide: 50,334
• Since beginning of last month:
  • Site-wide: None

Diagnostic value of skin manifestation of SARS-CoV-2 infection

• Downloaded 6,457 times
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  • Site-wide: 1,301
  • In epidemiology: 160
• Year to date:
  • Site-wide: 1,292
• Since beginning of last month:
  • Site-wide: 1,932

The effect of SARS-CoV-2 variant B.1.1.7 on symptomatology, re-infection and transmissibility

• Downloaded 5,465 times
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  • Site-wide: 1,652
  • In epidemiology: 193
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  • Site-wide: 83
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  • Site-wide: 39

Rapid implementation of mobile technology for real-time epidemiology of COVID-19

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  • Site-wide: 2,574
  • In epidemiology: 268
• Year to date:
  • Site-wide: 11,856
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  • Site-wide: 15,866

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,069 times
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  • Site-wide: 3,747
  • In genetics: 167
• Year to date:
  • Site-wide: 39,415
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  • Site-wide: 51,372

Geo-social gradients in predicted COVID-19 prevalence and severity in Great Britain: results from 2,266,235 users of the COVID-19 Symptoms Tracker app

• Downloaded 2,852 times
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  • Site-wide: 4,126
  • In epidemiology: 382
• Year to date:
  • Site-wide: 35,794
• Since beginning of last month:
  • Site-wide: 20,663

Genome-wide association study identifies 48 common genetic variants associated with handedness

• Downloaded 2,526 times
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  • Site-wide: 4,946
  • In genetics: 229
• Year to date:
  • Site-wide: 17,178
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  • Site-wide: 17,888

Detecting SARS-CoV-2 at point of care: Preliminary data comparing Loop-mediated isothermal amplification (LAMP) to PCR

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  • Site-wide: 4,993
  • In infectious diseases: 792
• Year to date:
  • Site-wide: 13,347
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  • Site-wide: 8,489

Interplay between the human gut microbiome and host metabolism

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  • Site-wide: 6,037
  • In microbiology: 338
• Year to date:
  • Site-wide: 41,090
• Since beginning of last month:
  • Site-wide: 25,996

The genetics of the human face: identification of large effect single gene variants

• Downloaded 1,811 times
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  • Site-wide: 8,078
  • In genetics: 393
• Year to date:
  • Site-wide: 47,959
• Since beginning of last month:
  • Site-wide: 45,655

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

• Downloaded 1,704 times
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  • Site-wide: 8,893
  • In genetics: 440
• Year to date:
  • Site-wide: 56,881
• Since beginning of last month:
  • Site-wide: 53,954

Dietary supplements during the COVID-19 pandemic: insights from 1.4M users of the COVID Symptom Study app - a longitudinal app-based community survey

• Downloaded 1,617 times
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  • Site-wide: 9,623
  • In public and global health: 205
• Year to date:
  • Site-wide: 1,176
• Since beginning of last month:
  • Site-wide: 1,477

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

• Downloaded 1,401 times
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  • Site-wide: 11,869
  • In genetics: 596
• Year to date:
  • Site-wide: 84,480
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  • Site-wide: 87,268

SARS-CoV-2 (COVID-19) infection in pregnant women: characterization of symptoms and syndromes predictive of disease and severity through real-time, remote participatory epidemiology.

• Downloaded 1,331 times
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  • Site-wide: 12,816
  • In epidemiology: 850
• Year to date:
  • Site-wide: 9,442
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  • Site-wide: 10,156

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,240 times
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  • Site-wide: 14,256
  • In genomics: 1,515
• Year to date:
  • Site-wide: 57,008
• Since beginning of last month:
  • Site-wide: 45,980

Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics

• Downloaded 1,193 times
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  • Site-wide: 15,116
  • In genetics: 774
• Year to date:
  • Site-wide: 63,403
• Since beginning of last month:
  • Site-wide: 53,830

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

• Downloaded 1,187 times
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  • Site-wide: 15,229
  • In genetics: 782
• Year to date:
  • Site-wide: 34,616
• Since beginning of last month:
  • Site-wide: 32,129

Profound perturbation of the human metabolome by obesity

• Downloaded 866 times
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  • Site-wide: 24,197
  • In genetics: 1,199
• Year to date:
  • Site-wide: 103,796
• Since beginning of last month:
  • Site-wide: 66,888

Association of social distancing and masking with risk of COVID-19

• Downloaded 764 times
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  • Site-wide: 28,783
  • In infectious diseases: 1,919
• Year to date:
  • Site-wide: 6,610
• Since beginning of last month:
  • Site-wide: 5,876

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 746 times
• Download rankings, all-time:
  • Site-wide: 29,807
  • In genomics: 2,731
• Year to date:
  • Site-wide: 72,834
• Since beginning of last month:
  • Site-wide: 66,779

Extensive weight loss can reduce immune age by altering IgG N-glycosylation

• Downloaded 718 times
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  • Site-wide: 31,418
  • In endocrinology: 18
• Year to date:
  • Site-wide: 18,638
• Since beginning of last month:
  • Site-wide: 17,094

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 711 times
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  • Site-wide: 31,900
  • In genetics: 1,583
• Year to date:
  • Site-wide: 15,168
• Since beginning of last month:
  • Site-wide: 11,650

Network-based metabolite ratios for an improved functional characterization of genome-wide association study results

• Downloaded 651 times
• Download rankings, all-time:
  • Site-wide: 35,844
  • In genetics: 1,758
• Year to date:
  • Site-wide: 83,280
• Since beginning of last month:
  • Site-wide: 79,773

Racial and ethnic determinants of Covid-19 risk

• Downloaded 639 times
• Download rankings, all-time:
  • Site-wide: 36,780
  • In public and global health: 506
• Year to date:
  • Site-wide: 22,603
• Since beginning of last month:
  • Site-wide: 19,862

Detecting COVID-19 infection hotspots in England using large-scale self-reported data from a mobile application

• Downloaded 547 times
• Download rankings, all-time:
  • Site-wide: 44,756
  • In epidemiology: 2,050
• Year to date:
  • Site-wide: 16,111
• Since beginning of last month:
  • Site-wide: 27,145

The Genomic Loci of Specific Human tRNA Genes Exhibit Ageing-Related DNA Hypermethylation

• Downloaded 538 times
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  • Site-wide: 45,653
  • In genomics: 3,700
• Year to date:
  • Site-wide: 22,300
• Since beginning of last month:
  • Site-wide: 19,472

Decreased IgG core fucosylation, a player in antibody-dependent cell-mediated cytotoxicity, is associated with autoimmune thyroid diseases

• Downloaded 531 times
• Download rankings, all-time:
  • Site-wide: 46,352
  • In immunology: 1,249
• Year to date:
  • Site-wide: 72,353
• Since beginning of last month:
  • Site-wide: 63,515

Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health

• Downloaded 475 times
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  • Site-wide: 52,659
  • In genomics: 4,104
• Year to date:
  • Site-wide: 69,003
• Since beginning of last month:
  • Site-wide: 51,971

Multi-omic analyses reveal antibody-dependent natural killer cell-mediated cytotoxicity in autoimmune thyroid diseases

• Downloaded 372 times
• Download rankings, all-time:
  • Site-wide: 67,544
  • In immunology: 1,819
• Year to date:
  • Site-wide: 103,696
• Since beginning of last month:
  • Site-wide: 98,379

Anosmia and other SARS-CoV-2 positive test-associated symptoms, across three national, digital surveillance platforms as the COVID-19 pandemic and response unfolded: an observation study

• Downloaded 365 times
• Download rankings, all-time:
  • Site-wide: 68,729
  • In infectious diseases: 2,895
• Year to date:
  • Site-wide: 3,954
• Since beginning of last month:
  • Site-wide: 5,418

Novel DNA methylation sites of glucose and insulin homeostasis: an integrative cross-omics analysis

• Downloaded 344 times
• Download rankings, all-time:
  • Site-wide: 72,210
  • In genomics: 4,984
• Year to date:
  • Site-wide: 122,517
• Since beginning of last month:
  • Site-wide: None

Cancer and risk of COVID-19 through a general community survey

• Downloaded 311 times
• Download rankings, all-time:
  • Site-wide: 78,499
  • In oncology: 109
• Year to date:
  • Site-wide: 107,801
• Since beginning of last month:
  • Site-wide: 91,469

KCND3 is a novel susceptibility locus for early repolarization

• Downloaded 247 times
• Download rankings, all-time:
  • Site-wide: 91,825
  • In genetics: 4,179
• Year to date:
  • Site-wide: 120,261
• Since beginning of last month:
  • Site-wide: 105,554

Introducing ExHiBITT – Exploring Host microbiome inTeractions in Twins-, a colon multiomic cohort study

• Downloaded 232 times
• Download rankings, all-time:
  • Site-wide: 94,910
  • In systems biology: 2,245
• Year to date:
  • Site-wide: 65,823
• Since beginning of last month:
  • Site-wide: 37,826