Author: Jordan W Smoller

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 811
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  • Site-wide: 21,351

The genetic architecture of the human cerebral cortex

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  • Site-wide: 1,004
  • In genetics: 30
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  • Site-wide: 15,973
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  • Site-wide: 15,973

Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 1,127
  • In genetics: 38
• Year to date:
  • Site-wide: 14,812
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  • Site-wide: 14,812

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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  • Site-wide: 2,024
  • In genomics: 216
• Year to date:
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  • Site-wide: 11,786

Phenome-wide Heritability Analysis of the UK Biobank

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  • Site-wide: 2,526
  • In genetics: 101
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  • Site-wide: 105,196
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Greater male than female variability in regional brain structure across the lifespan

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  • Site-wide: 3,026
  • In neuroscience: 235
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  • Site-wide: 16,695
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Psychiatric Genomics: An Update and an Agenda

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  • Site-wide: 3,309
  • In genetics: 134
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  • Site-wide: 55,492
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Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

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  • Site-wide: 4,093
  • In genetic and genomic medicine: 11
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  • Site-wide: 886
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Genome-wide association study identifies 48 common genetic variants associated with handedness

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  • Site-wide: 4,915
  • In genetics: 229
• Year to date:
  • Site-wide: 15,824
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  • Site-wide: 15,824

The Shared Genetic Basis of Educational Attainment and Cerebral Cortical Morphology

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  • Site-wide: 6,023
  • In genetics: 293
• Year to date:
  • Site-wide: 14,160
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  • Site-wide: 14,160

Minimal phenotyping yields GWAS hits of reduced specificity for major depression

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  • Site-wide: 6,958
  • In genetics: 341
• Year to date:
  • Site-wide: 45,883
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  • Site-wide: 45,883

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 8,314
  • In genetics: 407
• Year to date:
  • Site-wide: 34,239
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  • Site-wide: 34,239

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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  • Site-wide: 8,884
  • In genetics: 441
• Year to date:
  • Site-wide: 96,013
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  • Site-wide: 96,013

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

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  • Site-wide: 9,276
  • In genetics: 457
• Year to date:
  • Site-wide: 17,779
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  • Site-wide: 17,779

Genome-wide association study of over 40,000 bipolar disorder cases provides novel biological insights

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  • Site-wide: 10,121
  • In psychiatry and clinical psychology: 32
• Year to date:
  • Site-wide: 2,500
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  • Site-wide: 2,500

Penetrance and pleiotropy of polygenic risk scores for schizophrenia in 106,160 patients across four healthcare systems

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  • Site-wide: 10,925
  • In genetics: 544
• Year to date:
  • Site-wide: 86,620
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  • Site-wide: 86,620

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

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  • Site-wide: 11,261
  • In genetics: 560
• Year to date:
  • Site-wide: 12,495
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  • Site-wide: 12,495

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 11,256
  • In genomics: 1,254
• Year to date:
  • Site-wide: 55,435
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  • Site-wide: 55,435

Polygenic Prediction via Bayesian Regression and Continuous Shrinkage Priors

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  • Site-wide: 11,686
  • In genetics: 585
• Year to date:
  • Site-wide: 54,360
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  • Site-wide: 54,360

Genetic Architecture of 11 Major Psychiatric Disorders at Biobehavioral, Functional Genomic, and Molecular Genetic Levels of Analysis

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  • Site-wide: 11,797
  • In genetic and genomic medicine: 39
• Year to date:
  • Site-wide: 2,081
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  • Site-wide: 2,081

The All of Us Research Program: data quality, utility, and diversity

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  • Site-wide: 13,928
  • In public and global health: 256
• Year to date:
  • Site-wide: 7,035
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  • Site-wide: 7,035

Multidimensional Heritability Analysis of Neuroanatomical Shape

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  • Site-wide: 14,658
  • In neuroscience: 1,797
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  • Site-wide: 63,895
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  • Site-wide: 63,895

Testing Causal Bidirectional Influences between Physical Activity and Depression using Mendelian Randomization

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  • Site-wide: 17,154
  • In genetics: 873
• Year to date:
  • Site-wide: 73,768
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  • Site-wide: 73,768

Cortical Thickness Trajectories across the Lifespan: Data from 17,075 healthy individuals aged 3-90 years

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  • Site-wide: 19,775
  • In neuroscience: 2,533
• Year to date:
  • Site-wide: 11,693
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  • Site-wide: 11,693

A comprehensive evaluation of polygenic score methods across cohorts in psychiatric disorders

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  • Site-wide: 22,384
  • In genetic and genomic medicine: 68
• Year to date:
  • Site-wide: 4,951
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  • Site-wide: 4,951

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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  • Site-wide: 23,074
  • In genetics: 1,150
• Year to date:
  • Site-wide: 3,230
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  • Site-wide: 3,230

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

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  • Site-wide: 25,548
  • In genetics: 1,269
• Year to date:
  • Site-wide: 64,619
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  • Site-wide: 64,619

Planar cell polarity pathway and development of the human visual cortex

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  • Site-wide: 29,058
  • In neuroscience: 3,989
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  • Site-wide: 41,293
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  • Site-wide: 41,293

Subcortical Volume Trajectories across the Lifespan: Data from 18,605 healthy individuals aged 3-90 years

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  • Site-wide: 31,772
  • In neuroscience: 4,411
• Year to date:
  • Site-wide: 17,943
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  • Site-wide: 17,943

Cross-disorder GWAS meta-analysis for Attention Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Obsessive Compulsive Disorder, and Tourette Syndrome

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  • Site-wide: 32,110
  • In genetics: 1,601
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  • Site-wide: 36,354
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  • Site-wide: 36,354

A two-stage approach to identifying and validating modifiable factors for the prevention of depression

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  • Site-wide: 33,084
  • In genetics: 1,637
• Year to date:
  • Site-wide: 112,189
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  • Site-wide: 112,189

Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer

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  • Site-wide: 33,472
  • In genetic and genomic medicine: 96
• Year to date:
  • Site-wide: 4,505
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  • Site-wide: 4,505

Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

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  • Site-wide: 33,622
  • In genetics: 1,656
• Year to date:
  • Site-wide: 18,882
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  • Site-wide: 18,882

The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation

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  • Site-wide: 35,167
  • In biochemistry: 855
• Year to date:
  • Site-wide: 63,447
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  • Site-wide: 63,447

Analysis of Genetically Regulated Gene Expression identifies a trauma type specific PTSD gene, SNRNP35

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  • Site-wide: 39,315
  • In genetics: 1,911
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  • Site-wide: 120,766
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  • Site-wide: 120,766

GWAS meta-analysis highlights the hypothalamic-pituitary-gonadal axis (HPG axis) in the genetic regulation of menstrual cycle length

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  • Site-wide: 41,327
  • In genetics: 1,990
• Year to date:
  • Site-wide: 100,960
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  • Site-wide: 100,960

Prospective Study of Polygenic Risk, Protective Factors, and Incident Depression Following Combat Deployment in US Army Soldiers

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  • Site-wide: 43,738
  • In genetics: 2,113
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Genomewide Analyses of Psychological Resilience in US Army Soldiers

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  • Site-wide: 45,927
  • In genetics: 2,216
• Year to date:
  • Site-wide: 100,899
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  • Site-wide: 100,899

Contribution of rare copy number variants to bipolar disorder risk is limited to schizoaffective cases

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  • Site-wide: 47,921
  • In genetics: 2,293
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  • Site-wide: 96,924

Genetic variation in the Major Histocompatibility Complex and association with depression

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  • Site-wide: 59,825
  • In genetics: 2,836
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  • Site-wide: 113,291
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  • Site-wide: 113,291

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

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  • Site-wide: 60,756
  • In genetic and genomic medicine: 181
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  • Site-wide: 9,737

Genomic Influences on Self-Reported Childhood Maltreatment

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  • Site-wide: 67,063
  • In genomics: 4,750
• Year to date:
  • Site-wide: 101,972
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  • Site-wide: 101,972

Genetic validation of bipolar disorder identified by automated phenotyping using electronic health records

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  • Site-wide: 70,551
  • In genetics: 3,302
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  • Site-wide: 112,911
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  • Site-wide: 112,911

The restricted nature of protein glycosylation in the mammalian brain

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  • Site-wide: 80,767
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Generalizability of Polygenic Risk Scores for Breast Cancer in the Multiethnic eMERGE Study

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  • Site-wide: 104,023
  • In genetic and genomic medicine: 417
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  • Site-wide: 46,680

The schizophrenia-associated variant in SLC39A8 alters N-glycosylation in the mouse brain

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