Author: Torben Hansen

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Preprints

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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  • Site-wide: 3,501
  • In genomics: 397
• Year to date:
  • Site-wide: 67,332
• Since beginning of last month:
  • Site-wide: 52,519

Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetes

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  • Site-wide: 5,014
  • In genomics: 585
• Year to date:
  • Site-wide: 64,219
• Since beginning of last month:
  • Site-wide: 67,631

Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis

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  • Site-wide: 5,644
  • In epidemiology: 469
• Year to date:
  • Site-wide: None
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Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

• Downloaded 2,264 times
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  • Site-wide: 5,834
  • In genetics: 279
• Year to date:
  • Site-wide: 4,351
• Since beginning of last month:
  • Site-wide: 2,786

Archaic adaptive introgression in TBX15/WARS2

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  • Site-wide: 6,045
  • In evolutionary biology: 160
• Year to date:
  • Site-wide: 37,649
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  • Site-wide: 32,593

Large-scale association analyses identify host factors influencing human gut microbiome composition

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  • Site-wide: 7,101
  • In genetics: 346
• Year to date:
  • Site-wide: 2,586
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  • Site-wide: None

The Polygenic and Monogenic Basis of Blood Traits and Diseases

• Downloaded 1,949 times
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  • Site-wide: 7,232
  • In genetic and genomic medicine: 20
• Year to date:
  • Site-wide: 23,266
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  • Site-wide: 18,550

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,826 times
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  • Site-wide: 7,966
  • In genetics: 387
• Year to date:
  • Site-wide: None
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  • Site-wide: None

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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  • Site-wide: 8,888
  • In genetics: 440
• Year to date:
  • Site-wide: 56,079
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  • Site-wide: 54,444

Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries

• Downloaded 1,640 times
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  • Site-wide: 9,414
  • In genetics: 461
• Year to date:
  • Site-wide: 63,892
• Since beginning of last month:
  • Site-wide: 62,570

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,637 times
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  • Site-wide: 9,446
  • In genetics: 464
• Year to date:
  • Site-wide: 76,684
• Since beginning of last month:
  • Site-wide: 78,427

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

• Downloaded 1,401 times
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  • Site-wide: 11,860
  • In genetics: 595
• Year to date:
  • Site-wide: 84,692
• Since beginning of last month:
  • Site-wide: 82,089

A Comprehensive Reanalysis Of Publicly Available GWAS Datasets Reveals An X Chromosome Rare Regulatory Variant Associated With High Risk For Type 2 Diabetes.

• Downloaded 1,311 times
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  • Site-wide: 13,109
  • In genetics: 662
• Year to date:
  • Site-wide: 55,334
• Since beginning of last month:
  • Site-wide: 54,540

A paired liver biopsy and plasma proteomics study reveals circulating biomarkers for alcohol-related liver disease

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  • Site-wide: 15,832
  • In biochemistry: 315
• Year to date:
  • Site-wide: 5,288
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  • Site-wide: 5,008

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 980 times
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  • Site-wide: 20,270
  • In genetic and genomic medicine: 61
• Year to date:
  • Site-wide: 6,780
• Since beginning of last month:
  • Site-wide: 7,095

Selection on the FADS region in Europeans

• Downloaded 951 times
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  • Site-wide: 21,141
  • In genetics: 1,045
• Year to date:
  • Site-wide: 98,455
• Since beginning of last month:
  • Site-wide: 97,364

Extreme distribution of deleterious variation in a historically small and isolated population-insights from the Greenlandic Inuit

• Downloaded 810 times
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  • Site-wide: 26,545
  • In genetics: 1,327
• Year to date:
  • Site-wide: 84,350
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  • Site-wide: 86,261

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 798 times
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  • Site-wide: 27,087
  • In genetics: 1,350
• Year to date:
  • Site-wide: 26,165
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  • Site-wide: 44,890

Estimating narrow-sense heritability from genome-wide data in admixed populations

• Downloaded 770 times
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  • Site-wide: 28,477
  • In genetics: 1,421
• Year to date:
  • Site-wide: 58,891
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  • Site-wide: None

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

• Downloaded 765 times
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  • Site-wide: 28,714
  • In genetic and genomic medicine: 82
• Year to date:
  • Site-wide: 25,565
• Since beginning of last month:
  • Site-wide: 23,867

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 711 times
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  • Site-wide: 31,859
  • In genetics: 1,584
• Year to date:
  • Site-wide: 15,077
• Since beginning of last month:
  • Site-wide: 11,218

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 602 times
• Download rankings, all-time:
  • Site-wide: 39,614
  • In genetic and genomic medicine: 113
• Year to date:
  • Site-wide: 8,199
• Since beginning of last month:
  • Site-wide: 12,056

Multiethnic Meta-analysis Identifies New Loci for Pulmonary Function

• Downloaded 597 times
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  • Site-wide: 40,074
  • In genetics: 1,938
• Year to date:
  • Site-wide: 111,482
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  • Site-wide: None

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

• Downloaded 561 times
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  • Site-wide: 43,302
  • In genetics: 2,087
• Year to date:
  • Site-wide: 58,455
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  • Site-wide: None

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

• Downloaded 504 times
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  • Site-wide: 49,231
  • In genetics: 2,349
• Year to date:
  • Site-wide: 3,745
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  • Site-wide: None

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 474 times
• Download rankings, all-time:
  • Site-wide: 52,746
  • In genetics: 2,508
• Year to date:
  • Site-wide: 90,181
• Since beginning of last month:
  • Site-wide: 78,688

Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study

• Downloaded 398 times
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  • Site-wide: 63,319
  • In genetic and genomic medicine: 188
• Year to date:
  • Site-wide: 87,418
• Since beginning of last month:
  • Site-wide: 73,136

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium

• Downloaded 332 times
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  • Site-wide: 74,440
  • In epidemiology: 3,072
• Year to date:
  • Site-wide: 83,117
• Since beginning of last month:
  • Site-wide: 81,343

Microbiome Determinants and Physiological Effects of the Benzoate-Hippurate Microbial-Host Co-Metabolic Pathway

• Downloaded 328 times
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  • Site-wide: 75,092
  • In systems biology: 1,823
• Year to date:
  • Site-wide: 79,033
• Since beginning of last month:
  • Site-wide: None

Maternal and fetal genetic contribution to gestational weight gain

• Downloaded 275 times
• Download rankings, all-time:
  • Site-wide: 85,616
  • In genetics: 3,929
• Year to date:
  • Site-wide: 120,242
• Since beginning of last month:
  • Site-wide: 97,475

Exome-wide association study on Albuminuria identifies a novel rare variant in CUBN and additional genes, in 33,985 Europeans with and without diabetes

• Downloaded 263 times
• Download rankings, all-time:
  • Site-wide: 88,297
  • In genetics: 4,038
• Year to date:
  • Site-wide: 76,686
• Since beginning of last month:
  • Site-wide: 98,125

Describing the fecal metabolome in cryogenically collected samples from healthy participants.

• Downloaded 258 times
• Download rankings, all-time:
  • Site-wide: 89,254
  • In systems biology: 2,124
• Year to date:
  • Site-wide: 111,462
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  • Site-wide: None

Explaining Deep Neural Networks for Knowledge Discovery in Electrocardiogram Analysis

• Downloaded 175 times
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  • Site-wide: 107,027
  • In cardiovascular medicine: 225
• Year to date:
  • Site-wide: 5,626
• Since beginning of last month:
  • Site-wide: 11,704

SorCS1 binds the insulin receptor to enhance insulin sensitivity

• Downloaded 149 times
• Download rankings, all-time:
  • Site-wide: 112,287
  • In physiology: 1,267
• Year to date:
  • Site-wide: 48,858
• Since beginning of last month:
  • Site-wide: 49,465