Author: Sharon LR Kardia

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Preprints

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

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Heterogeneity in polygenic scores for common human traits

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Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

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Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

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Population sequencing data reveal a compendium of mutational processes in human germline

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Novel genetic determinants of telomere length from a multi-ethnic analysis of 75,000 whole genome sequences in TOPMed

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Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

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Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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Exome chip meta-analysis elucidates the genetic architecture of rare coding variants in smoking and drinking behavior

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Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

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Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

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