Author: Matthew T Weirauch

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Preprints

Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers

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Molecular evolutionary trends and feeding ecology diversification in the Hemiptera, anchored by the milkweed bug genome

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Topoisomerase 1 inhibition therapy protects against SARS-CoV-2-induced inflammation and death in animal models.

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maxATAC: genome-scale transcription-factor binding prediction from ATAC-seq with deep neural networks

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  • In bioinformatics: 3,357
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The Glossina Genome Cluster: Comparative Genomic Analysis of the Vectors of African Trypanosomes

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Functional genomics of the stable fly, Stomoxys calcitrans, reveals mechanisms underlying reproduction, host interactions, and novel targets for pest control

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Super-enhancer switching drives a burst in germline gene expression at the mitosis-to-meiosis transition

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A model species for agricultural pest genomics: the genome of the Colorado potato beetle, Leptinotarsa decemlineata (Coleoptera: Chrysomelidae)

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Genome-enabled insights into the biology of thrips as crop pests

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Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endodermal gene regulatory network

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Epstein-Barr virus nuclear antigen 2 (EBNA2) extensively rewires the human chromatin landscape at autoimmune risk loci

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Genome-wide discovery of lupus genetic risk variant allelic regulatory activity

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Co-Stimulation-Induced AP-1 Activity is Required for Chromatin Opening During T Cell Activation

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  • In immunology: 1,557
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GWAS defines pathogenic signaling pathways and prioritizes drug targets for IgA nephropathy

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  • In genetic and genomic medicine: 565
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Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration

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Genomic programming of antigen cross-presentation in IRF4-expressing human Langerhans cells

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Multi-level analysis of reproduction in the Antarctic midge, Belgica antarctica, identifies female and male accessory gland products that are altered by larval stress and impact progeny viability

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Meta-analysis of 208,370 East Asians identifies 113 genomic loci and yields new non-immune cell relevant biological insights for systemic lupus erythematosus

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  • Site-wide: 75,986
  • In genetic and genomic medicine: 383
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Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks

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  • Site-wide: 90,991
  • In developmental biology: 2,238
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Genetic, inflammatory, and epithelial cell differentiation factors control expression of human calpain-14

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CRISPRa screen on a genetic risk locus shared by multiple autoimmune diseases identifies a dysfunctional enhancer that affects IRF8 expression through cooperative lncRNA and DNA methylation machinery

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  • In genetics: 4,775
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SLE non-coding Genetic Risk Variant Determines the Epigenetic Dysfunction of an Immune Cell Specific Enhancer that Controls Disease-critical microRNA Expression

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Definition of germ layer cell lineage alternative splicing programs reveals a critical role for Quaking in specifying cardiac cell fate

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  • In molecular biology: 3,716
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Runx1 Shapes the Chromatin Landscape Via a Cascade of Direct and Indirect Targets

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Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor

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  • In developmental biology: 3,851
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Epigenetic and Transcriptional Dysregulation in CD4+ T cells of Patients with Atopic Dermatitis

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VExD: A curated resource for human gene expression following viral infection

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