Author: J. Wouter Jukema

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Preprints

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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  • In genomics: 416
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Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • In genetics: 168
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Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

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Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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  • In genetic and genomic medicine: 64
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Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

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The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

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  • In bioinformatics: 3,715
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Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

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  • In epidemiology: 1,841
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Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

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  • In genetics: 1,953
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Discovering patterns of pleiotropy in genome-wide association studies

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Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

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Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

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  • In neuroscience: 9,070
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High Density Lipoprotein pathway as a therapeutic target for coronary heart disease: individual participant meta-analysis in 28,597 individuals with 4197 coronary events

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  • Site-wide: 89,297
  • In cardiovascular medicine: 148
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Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

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Investigating the relationships between unfavorable sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses

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  • In epidemiology: 4,766
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