Author: Joshua C Bis

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Preprints

The genetic architecture of the human cerebral cortex

• Downloaded 7,906 times
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  • Site-wide: 1,003
  • In genetics: 30
• Year to date:
  • Site-wide: 15,700
• Since beginning of last month:
  • Site-wide: 15,700

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

• Downloaded 3,247 times
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  • Site-wide: 3,453
  • In genetics: 146
• Year to date:
  • Site-wide: 23,853
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  • Site-wide: 23,853

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,069 times
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  • Site-wide: 3,728
  • In genetics: 166
• Year to date:
  • Site-wide: 35,664
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  • Site-wide: 35,664

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

• Downloaded 2,773 times
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  • Site-wide: 4,280
  • In genomics: 494
• Year to date:
  • Site-wide: 6,541
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  • Site-wide: 6,541

New insights on the genetic etiology of Alzheimer and related dementia

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  • Site-wide: 5,422
  • In neurology: 11
• Year to date:
  • Site-wide: 912
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  • Site-wide: 912

Common variants in Alzheimer's disease: Novel association of six genetic variants with AD and risk stratification by polygenic risk scores

• Downloaded 2,349 times
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  • Site-wide: 5,508
  • In genetic and genomic medicine: 15
• Year to date:
  • Site-wide: 8,415
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  • Site-wide: 8,415

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

• Downloaded 1,826 times
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  • Site-wide: 7,928
  • In neuroscience: 837
• Year to date:
  • Site-wide: None
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  • Site-wide: None

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

• Downloaded 1,700 times
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  • Site-wide: 8,873
  • In genetics: 441
• Year to date:
  • Site-wide: 97,236
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  • Site-wide: 97,236

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

• Downloaded 1,393 times
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  • Site-wide: 11,907
  • In genetics: 599
• Year to date:
  • Site-wide: 34,269
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  • Site-wide: 34,269

Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

• Downloaded 829 times
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  • Site-wide: 25,626
  • In genetics: 1,270
• Year to date:
  • Site-wide: 84,595
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  • Site-wide: 84,595

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

• Downloaded 813 times
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  • Site-wide: 26,297
  • In genetics: 1,311
• Year to date:
  • Site-wide: 43,447
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  • Site-wide: 43,447

Quality Control and Integration of Genotypes from Two Calling Pipelines for Whole Genome Sequence Data in the Alzheimer's Disease Sequencing Project

• Downloaded 791 times
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  • Site-wide: 27,326
  • In genetics: 1,358
• Year to date:
  • Site-wide: 39,172
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  • Site-wide: 39,172

Planar cell polarity pathway and development of the human visual cortex

• Downloaded 757 times
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  • Site-wide: 29,038
  • In neuroscience: 3,985
• Year to date:
  • Site-wide: 41,392
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  • Site-wide: 41,392

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 746 times
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  • Site-wide: 29,651
  • In genomics: 2,713
• Year to date:
  • Site-wide: 67,772
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  • Site-wide: 67,772

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

• Downloaded 709 times
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  • Site-wide: 31,826
  • In bioinformatics: 3,615
• Year to date:
  • Site-wide: None
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  • Site-wide: None

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

• Downloaded 660 times
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  • Site-wide: 35,049
  • In genomics: 3,068
• Year to date:
  • Site-wide: 48,650
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  • Site-wide: 48,650

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 601 times
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  • Site-wide: 39,565
  • In genetics: 1,918
• Year to date:
  • Site-wide: 63,951
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  • Site-wide: 63,951

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

• Downloaded 504 times
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  • Site-wide: 49,052
  • In genetics: 2,351
• Year to date:
  • Site-wide: 3,437
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  • Site-wide: 3,437

Genetic variants for head size share genes and pathways with cancer

• Downloaded 334 times
• Download rankings, all-time:
  • Site-wide: 73,660
  • In genomics: 5,020
• Year to date:
  • Site-wide: 40,843
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  • Site-wide: 40,843

Cholesteryl Ester Transfer Protein as a Drug Target

• Downloaded 286 times
• Download rankings, all-time:
  • Site-wide: 83,035
  • In cardiovascular medicine: 128
• Year to date:
  • Site-wide: 45,227
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  • Site-wide: 45,227

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 286 times
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  • Site-wide: 82,956
  • In genetics: 3,831
• Year to date:
  • Site-wide: 25,835
• Since beginning of last month:
  • Site-wide: 25,835

Association of mitochondrial DNA copy number with cardiometabolic diseases in a large cross-sectional study of multiple ancestries

• Downloaded 265 times
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  • Site-wide: 87,444
  • In epidemiology: 3,560
• Year to date:
  • Site-wide: 31,431
• Since beginning of last month:
  • Site-wide: 31,431

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 199 times
• Download rankings, all-time:
  • Site-wide: 101,758
  • In genomics: 6,010
• Year to date:
  • Site-wide: 94,303
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  • Site-wide: 94,303

Population Stratification at the Phenotypic Variance level and Implication for the Analysis of Whole Genome Sequencing Data from Multiple Studies

• Downloaded 193 times
• Download rankings, all-time:
  • Site-wide: 103,021
  • In genetics: 4,620
• Year to date:
  • Site-wide: 89,950
• Since beginning of last month:
  • Site-wide: 89,950