Author: Trever G. Bivona

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Preprints

Efficacy of SHP2 phosphatase inhibition in cancers with nucleotide-cycling oncogenic RAS, RAS-GTP dependent oncogenic BRAF and NF1 loss

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  • Site-wide: 1,765
  • In cancer biology: 25
• Year to date:
  • Site-wide: 4,581
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  • Site-wide: 7,584

Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts

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  • Site-wide: 3,485
  • In cancer biology: 56
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Heterogeneity and targeted therapy-induced adaptations in lung cancer revealed by longitudinal single-cell RNA sequencing

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  • Site-wide: 5,799
  • In cancer biology: 86
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Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules

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  • Site-wide: 8,387
  • In cancer biology: 152
• Year to date:
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Evolution and clinical impact of genetic epistasis within EGFR-mutant lung cancers

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  • Site-wide: 11,485
  • In cancer biology: 241
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Co-occurring alterations in the RAS-MAPK pathway limit response to MET inhibitor treatment in MET exon 14 skipping mutation positive lung cancer

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  • Site-wide: 13,410
  • In cancer biology: 289
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The CIC-DUX4 fusion oncoprotein drives metastasis and tumor growth via distinct downstream regulatory programs and therapeutic targets in sarcoma

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  • Site-wide: 20,535
  • In cancer biology: 498
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A tyrosine kinase protein interaction map reveals targetable EGFR network oncogenesis in lung cancer

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  • Site-wide: 30,820
  • In cancer biology: 832
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Synthetic essentiality of metabolic regulator PDHK1 in PTEN-deficient cells and cancers

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  • Site-wide: 35,765
  • In cancer biology: 974
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Targeted cancer therapy induces APOBEC fuelling the evolution of drug resistance

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  • Site-wide: 38,811
  • In cancer biology: 1,061
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  • Site-wide: 1,610
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Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolution

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  • Site-wide: 42,799
  • In cancer biology: 1,191
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  • Site-wide: 98,168

Global analysis of epigenetic heterogeneity identifies divergent drivers of esophageal squamous cell carcinoma

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  • Site-wide: 48,309
  • In cell biology: 2,098
• Year to date:
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  • Site-wide: 79,161