Author: Xiuqing Guo

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Preprints

Recovery of trait heritability from whole genome sequence data

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  • Site-wide: 624
  • In genetics: 17
• Year to date:
  • Site-wide: 2,083
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  • Site-wide: 2,083

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

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  • Site-wide: 986
  • In genomics: 92
• Year to date:
  • Site-wide: 1,288
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  • Site-wide: 1,288

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

• Downloaded 3,223 times
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  • Site-wide: 3,489
  • In genomics: 397
• Year to date:
  • Site-wide: 62,768
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  • Site-wide: 62,768

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 3,728
  • In genetics: 166
• Year to date:
  • Site-wide: 35,664
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  • Site-wide: 35,664

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

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  • Site-wide: 4,280
  • In genomics: 494
• Year to date:
  • Site-wide: 6,541
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  • Site-wide: 6,541

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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  • Site-wide: 7,929
  • In genetics: 385
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  • Site-wide: None
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  • Site-wide: None

Identification of type 2 diabetes loci in 433,540 East Asian individuals

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  • Site-wide: 8,279
  • In genetics: 403
• Year to date:
  • Site-wide: 27,891
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  • Site-wide: 27,891

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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  • Site-wide: 9,406
  • In genetics: 462
• Year to date:
  • Site-wide: 72,619
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  • Site-wide: 72,619

Novel genetic determinants of telomere length from a trans-ethnic analysis of 109,122 whole genome sequences in TOPMed

• Downloaded 1,315 times
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  • Site-wide: 12,989
  • In genetics: 659
• Year to date:
  • Site-wide: 7,337
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  • Site-wide: 7,337

Genetic architecture of gene expression traits across diverse populations

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  • Site-wide: 14,793
  • In genomics: 1,559
• Year to date:
  • Site-wide: 82,014
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  • Site-wide: 82,014

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

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  • Site-wide: 15,156
  • In genetics: 780
• Year to date:
  • Site-wide: 32,631
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  • Site-wide: 32,631

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

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  • Site-wide: 18,905
  • In genetics: 943
• Year to date:
  • Site-wide: 5,937
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  • Site-wide: 5,937

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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  • Site-wide: 20,144
  • In genetic and genomic medicine: 60
• Year to date:
  • Site-wide: 6,175
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  • Site-wide: 6,175

A high-resolution HLA reference panel capturing global population diversity enables multi-ethnic fine-mapping in HIV host response

• Downloaded 973 times
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  • Site-wide: 20,348
  • In hiv aids: 8
• Year to date:
  • Site-wide: 10,222
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  • Site-wide: 10,222

Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

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  • Site-wide: 25,626
  • In genetics: 1,270
• Year to date:
  • Site-wide: 84,595
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  • Site-wide: 84,595

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

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  • Site-wide: 26,297
  • In genetics: 1,311
• Year to date:
  • Site-wide: 43,447
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  • Site-wide: 43,447

A genome-wide association study for nonalcoholic fatty liver disease identifies novel genetic loci and trait-relevant candidate genes in the Million Veteran Program.

• Downloaded 807 times
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  • Site-wide: 26,562
  • In genetic and genomic medicine: 77
• Year to date:
  • Site-wide: 615
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  • Site-wide: 615

Machine learning enables new insights into clinical significance of and genetic contributions to liver fat accumulation

• Downloaded 799 times
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  • Site-wide: 26,934
  • In genetic and genomic medicine: 78
• Year to date:
  • Site-wide: 7,987
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  • Site-wide: 7,987

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 794 times
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  • Site-wide: 27,156
  • In genetics: 1,353
• Year to date:
  • Site-wide: 26,470
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  • Site-wide: 26,470

rs641738C>T near MBOAT7 promotes steatosis, NASH, fibrosis and hepatocellular carcinoma in non-alcoholic fatty liver disease: a meta-analysis

• Downloaded 766 times
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  • Site-wide: 28,588
  • In gastroenterology: 20
• Year to date:
  • Site-wide: 22,684
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  • Site-wide: 22,684

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 746 times
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  • Site-wide: 29,651
  • In genomics: 2,713
• Year to date:
  • Site-wide: 67,772
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  • Site-wide: 67,772

Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

• Downloaded 736 times
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  • Site-wide: 30,183
  • In genomics: 2,753
• Year to date:
  • Site-wide: 53,903
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  • Site-wide: 53,903

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 711 times
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  • Site-wide: 31,727
  • In genetics: 1,576
• Year to date:
  • Site-wide: 13,852
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  • Site-wide: 13,852

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

• Downloaded 709 times
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  • Site-wide: 31,843
  • In genetics: 1,587
• Year to date:
  • Site-wide: 98,970
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  • Site-wide: 98,970

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 601 times
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  • Site-wide: 39,565
  • In genetics: 1,918
• Year to date:
  • Site-wide: 63,951
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  • Site-wide: 63,951

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

• Downloaded 504 times
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  • Site-wide: 49,052
  • In genetics: 2,351
• Year to date:
  • Site-wide: 3,437
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  • Site-wide: 3,437

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 501 times
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  • Site-wide: 49,342
  • In genomics: 3,914
• Year to date:
  • Site-wide: 106,960
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  • Site-wide: 106,960

Whole-Genome Association Analyses of Sleep-disordered Breathing Phenotypes in the NHLBI TOPMed Program

• Downloaded 426 times
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  • Site-wide: 58,850
  • In genetics: 2,795
• Year to date:
  • Site-wide: 61,383
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  • Site-wide: 61,383

Impact of rare and common genetic variants on diabetes diagnosis by hemoglobin A1c in multi-ancestry cohorts: The Trans-Omics for Precision Medicine Program.

• Downloaded 374 times
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  • Site-wide: 66,941
  • In genetics: 3,132
• Year to date:
  • Site-wide: 63,850
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  • Site-wide: 63,850

Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Humans and Mice

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  • Site-wide: 69,853
  • In physiology: 520
• Year to date:
  • Site-wide: 48,327
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  • Site-wide: 48,327

Multi-ethnic genome-wide association study of decomposed cardioelectric phenotypes illustrates strategies to identify and characterize evidence of shared genetic effects for complex traits

• Downloaded 350 times
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  • Site-wide: 70,929
  • In epidemiology: 2,945
• Year to date:
  • Site-wide: 110,496
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  • Site-wide: 110,496

Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

• Downloaded 290 times
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  • Site-wide: 82,197
  • In epidemiology: 3,364
• Year to date:
  • Site-wide: 61,796
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  • Site-wide: 61,796

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 286 times
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  • Site-wide: 82,956
  • In genetics: 3,831
• Year to date:
  • Site-wide: 25,835
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  • Site-wide: 25,835

Robust, flexible, and scalable tests for Hardy-Weinberg Equilibrium across diverse ancestries

• Downloaded 276 times
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  • Site-wide: 85,116
  • In bioinformatics: 7,644
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  • Site-wide: None
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  • Site-wide: None

Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes: Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 271 times
• Download rankings, all-time:
  • Site-wide: 86,217
  • In genetic and genomic medicine: 288
• Year to date:
  • Site-wide: 19,977
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  • Site-wide: 19,977

Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium

• Downloaded 269 times
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  • Site-wide: 86,731
  • In genetics: 3,970
• Year to date:
  • Site-wide: 102,500
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  • Site-wide: 102,500

Association of mitochondrial DNA copy number with cardiometabolic diseases in a large cross-sectional study of multiple ancestries

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  • Site-wide: 87,444
  • In epidemiology: 3,560
• Year to date:
  • Site-wide: 31,431
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  • Site-wide: 31,431

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

• Downloaded 261 times
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  • Site-wide: 88,234
  • In genetics: 4,054
• Year to date:
  • Site-wide: 116,989
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  • Site-wide: 116,989

GWAS of QRS Duration Identifies New Loci Specific to Hispanic/Latino Populations

• Downloaded 255 times
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  • Site-wide: 89,586
  • In genetics: 4,097
• Year to date:
  • Site-wide: 117,345
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  • Site-wide: 117,345

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 199 times
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  • Site-wide: 101,758
  • In genomics: 6,010
• Year to date:
  • Site-wide: 94,303
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  • Site-wide: 94,303

Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program

• Downloaded 148 times
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  • Site-wide: 112,156
  • In genetic and genomic medicine: 486
• Year to date:
  • Site-wide: 6,417
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  • Site-wide: 6,417

BinomiRare: A carriers-only test for association of rare genetic variants with a binary outcome for mixed models and any case-control proportion

• Downloaded 148 times
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  • Site-wide: 112,158
  • In genetic and genomic medicine: 487
• Year to date:
  • Site-wide: 6,420
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  • Site-wide: 6,420