Author: Cathryn M. Lewis

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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Genomewide association study identifies 30 loci associated with bipolar disorder

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Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

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Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

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ukbtools: An R package to manage and query UK Biobank data

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Minimal phenotyping yields GWAS hits of reduced specificity for major depression

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Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

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Pharmacogenetic testing through the direct-to-consumer genetic testing company 23andMe

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Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

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Cost-effectiveness of pharmacogenetic-guided treatment: are we there yet?

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Pharmacogenetics of antidepressant response: a polygenic approach

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Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

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Transforming summary statistics from logistic regression to the liability scale: application to genetic and environmental risk scores

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Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

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The Maudsley Environmental Risk Score for Psychosis

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Identifying Potential Causal Risk Factors for Self-Harm: A Polygenic Risk Scoring and Mendelian Randomisation Approach

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Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: meta-analysis of data from genome-wide association studies

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Polygenic risk scores for major depressive disorder and neuroticism as predictors of antidepressant response: meta-analysis of three treatment cohorts.

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The independent and combined influence of schizophrenia polygenic risk score and heavy cannabis use on risk for psychotic disorder: A case-control analysis from the EUGEI study.

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Cannabis-associated symptom profiles in patients with first episode psychosis and population controls

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Genetic variation in the Major Histocompatibility Complex and association with depression

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Impute.me: an open source, non-profit tool for using data from DTC genetic testing to calculate and interpret polygenic risk scores.

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Predictors of intestinal inflammation in asymptomatic first-degree relatives of patients with Crohn's disease

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Delineating the Genetic Component of Gene Expression in Major Depression

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Investigating an in-silico approach for prioritizing antidepressant drug prescription based on drug-induced expression profiles and predicted gene expression

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