Author: Cathryn M Lewis

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Preprints

Genomewide association study identifies 30 loci associated with bipolar disorder

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Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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  • In genetics: 83
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Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

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Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

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ukbtools: An R package to manage and query UK Biobank data

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  • In epidemiology: 483
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Minimal phenotyping yields GWAS hits of reduced specificity for major depression

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Genome-wide association study of over 40,000 bipolar disorder cases provides novel biological insights

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  • In psychiatry and clinical psychology: 32
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Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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Genetic Architecture of 11 Major Psychiatric Disorders at Biobehavioral, Functional Genomic, and Molecular Genetic Levels of Analysis

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  • In genetic and genomic medicine: 39
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116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

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  • Site-wide: 12,588
  • In genetics: 634
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Pharmacogenetic testing through the direct-to-consumer genetic testing company 23andMe

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Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

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Transforming summary statistics from logistic regression to the liability scale: application to genetic and environmental risk scores

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Cost-effectiveness of pharmacogenetic-guided treatment: are we there yet?

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Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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Identifying Potential Causal Risk Factors for Self-Harm: A Polygenic Risk Scoring and Mendelian Randomisation Approach

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  • In epidemiology: 1,275
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Pharmacogenetics of antidepressant response: a polygenic approach

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Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

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Atypical depression shares genetic predisposition with immuno-metabolic traits: a population-based study

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  • Site-wide: 33,503
  • In genetic and genomic medicine: 96
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The Maudsley Environmental Risk Score for Psychosis

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Evaluation of Polygenic Prediction Methodology within a Reference-Standardized Framework

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Impute.me: an open source, non-profit tool for using data from DTC genetic testing to calculate and interpret polygenic risk scores.

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  • Site-wide: 43,363
  • In genetics: 2,090
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Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts

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  • Site-wide: 47,120
  • In psychiatry and clinical psychology: 144
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Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: meta-analysis of data from genome-wide association studies

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  • Site-wide: 47,577
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The independent and combined influence of schizophrenia polygenic risk score and heavy cannabis use on risk for psychotic disorder: A case-control analysis from the EUGEI study.

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Delineating the Genetic Component of Gene Expression in Major Depression

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Cannabis-associated symptom profiles in patients with first episode psychosis and population controls

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  • In neuroscience: 8,632
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Polygenic risk scores for major depressive disorder and neuroticism as predictors of antidepressant response: meta-analysis of three treatment cohorts.

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  • In genetics: 2,713
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Genetic variation in the Major Histocompatibility Complex and association with depression

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Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

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  • In genetic and genomic medicine: 182
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  • Site-wide: 16,398

Predictors of intestinal inflammation in asymptomatic first-degree relatives of patients with Crohn's disease

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Schizophrenia polygenic risk score and cannabis use modify psychosis expression in first episode psychosis patients and population controls

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  • In psychiatry and clinical psychology: 190
• Year to date:
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  • Site-wide: 41,066

Multiple measures of depression to enhance validity of Major Depressive Disorder in the UK Biobank

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  • Site-wide: 71,014
  • In genetic and genomic medicine: 216
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Antidepressant Response in Major Depressive Disorder: A Genome-wide Association Study

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  • Site-wide: 77,019
  • In psychiatry and clinical psychology: 239
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A polygenic predictor of treatment-resistant depression using whole exome sequencing and genome-wide genotyping

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  • Site-wide: 83,171
  • In genetic and genomic medicine: 270
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Exploring health in the UK Biobank: associations with sociodemographic characteristics, psychosocial factors, lifestyle and environmental exposures

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Phenotypic Associations and Shared Genetic Etiology between Bipolar Disorder and Cardiometabolic Traits

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Whats in a diagnosis? A genetic decomposition of major depression.

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  • Site-wide: 102,684
  • In genetic and genomic medicine: 400
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Investigating an in-silico approach for prioritizing antidepressant drug prescription based on drug-induced expression profiles and predicted gene expression

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  • In bioinformatics: 8,734
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Cost-effectiveness of genetic and clinical predictors for choosing combined psychotherapy and pharmacotherapy in major depression

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  • Site-wide: 107,964
  • In psychiatry and clinical psychology: 419
• Year to date:
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Examining the association between family status and depression in the UK Biobank

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Shared genetic factors do not account for the observed co-occurrence of depression and autoimmune diseases in the UK Biobank

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  • In psychiatry and clinical psychology: 579
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Lifetime depression and age-related changes in body composition, cardiovascular function, grip strength and lung function: sex-specific analyses in the UK Biobank

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