Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 62,709 bioRxiv papers from 278,266 authors.

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

• Downloaded 8,726 times
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  • Site-wide: 138 out of 62,709
  • In genetics: 13 out of 3,561
• Year to date:
  • Site-wide: 2,283 out of 62,709
• Since beginning of last month:
  • Site-wide: 8,871 out of 62,709

Genomewide association study identifies 30 loci associated with bipolar disorder

• Downloaded 6,099 times
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  • Site-wide: 282 out of 62,709
  • In genetics: 32 out of 3,561
• Year to date:
  • Site-wide: 289 out of 62,709
• Since beginning of last month:
  • Site-wide: 2,051 out of 62,709

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

• Downloaded 3,684 times
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  • Site-wide: 735 out of 62,709
  • In genetics: 72 out of 3,561
• Year to date:
  • Site-wide: 434 out of 62,709
• Since beginning of last month:
  • Site-wide: 2,601 out of 62,709

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

• Downloaded 2,893 times
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  • Site-wide: 1,158 out of 62,709
  • In genomics: 274 out of 4,312
• Year to date:
  • Site-wide: 190 out of 62,709
• Since beginning of last month:
  • Site-wide: 1,615 out of 62,709

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

• Downloaded 2,697 times
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  • Site-wide: 1,304 out of 62,709
  • In genomics: 301 out of 4,312
• Year to date:
  • Site-wide: 1,930 out of 62,709
• Since beginning of last month:
  • Site-wide: 3,638 out of 62,709

Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

• Downloaded 2,267 times
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  • Site-wide: 1,771 out of 62,709
  • In genetics: 169 out of 3,561
• Year to date:
  • Site-wide: 23,136 out of 62,709
• Since beginning of last month:
  • Site-wide: 24,422 out of 62,709

ukbtools: An R package to manage and query UK Biobank data

• Downloaded 1,798 times
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  • Site-wide: 2,679 out of 62,709
  • In epidemiology: 29 out of 1,556
• Year to date:
  • Site-wide: 5,263 out of 62,709
• Since beginning of last month:
  • Site-wide: 16,759 out of 62,709

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

• Downloaded 1,276 times
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  • Site-wide: 4,735 out of 62,709
  • In genomics: 837 out of 4,312
• Year to date:
  • Site-wide: 19,224 out of 62,709
• Since beginning of last month:
  • Site-wide: 36,203 out of 62,709

Minimal phenotyping yields GWAS hits of low specificity for major depression

• Downloaded 1,165 times
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  • Site-wide: 5,502 out of 62,709
  • In genetics: 441 out of 3,561
• Year to date:
  • Site-wide: 2,163 out of 62,709
• Since beginning of last month:
  • Site-wide: 2,576 out of 62,709

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

• Downloaded 1,107 times
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  • Site-wide: 6,001 out of 62,709
  • In genetics: 488 out of 3,561
• Year to date:
  • Site-wide: 28,506 out of 62,709
• Since beginning of last month:
  • Site-wide: 41,825 out of 62,709

Pharmacogenetic testing through the direct-to-consumer genetic testing company 23andMe

• Downloaded 998 times
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  • Site-wide: 7,089 out of 62,709
  • In genetics: 555 out of 3,561
• Year to date:
  • Site-wide: 35,609 out of 62,709
• Since beginning of last month:
  • Site-wide: 31,061 out of 62,709

Cost-effectiveness of pharmacogenetic-guided treatment: are we there yet?

• Downloaded 807 times
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  • Site-wide: 9,917 out of 62,709
  • In genetics: 728 out of 3,561
• Year to date:
  • Site-wide: 45,684 out of 62,709
• Since beginning of last month:
  • Site-wide: 52,449 out of 62,709

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

• Downloaded 662 times
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  • Site-wide: 13,202 out of 62,709
  • In genetics: 931 out of 3,561
• Year to date:
  • Site-wide: 10,356 out of 62,709
• Since beginning of last month:
  • Site-wide: 28,227 out of 62,709

Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

• Downloaded 656 times
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  • Site-wide: 13,357 out of 62,709
  • In genetics: 940 out of 3,561
• Year to date:
  • Site-wide: None out of 62,709
• Since beginning of last month:
  • Site-wide: None out of 62,709

Pharmacogenetics of antidepressant response: a polygenic approach

• Downloaded 645 times
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  • Site-wide: 13,665 out of 62,709
  • In genetics: 957 out of 3,561
• Year to date:
  • Site-wide: 30,566 out of 62,709
• Since beginning of last month:
  • Site-wide: 26,311 out of 62,709

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

• Downloaded 576 times
• Download rankings, all-time:
  • Site-wide: 15,950 out of 62,709
  • In genetics: 1,095 out of 3,561
• Year to date:
  • Site-wide: 16,729 out of 62,709
• Since beginning of last month:
  • Site-wide: 26,829 out of 62,709

Establishing the characteristics of an effective pharmacogenetic test for clozapine induced agranulocytosis

• Downloaded 565 times
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  • Site-wide: 16,370 out of 62,709
  • In genetics: 1,115 out of 3,561
• Year to date:
  • Site-wide: 59,804 out of 62,709
• Since beginning of last month:
  • Site-wide: 60,322 out of 62,709

Transforming summary statistics from logistic regression to the liability scale: application to genetic and environmental risk scores

• Downloaded 535 times
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  • Site-wide: 17,601 out of 62,709
  • In epidemiology: 216 out of 1,556
• Year to date:
  • Site-wide: 9,379 out of 62,709
• Since beginning of last month:
  • Site-wide: 17,872 out of 62,709

New insights on the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies: rare variant analysis and high-density imputation

• Downloaded 486 times
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  • Site-wide: 19,818 out of 62,709
  • In genomics: 2,297 out of 4,312
• Year to date:
  • Site-wide: 47,418 out of 62,709
• Since beginning of last month:
  • Site-wide: 46,809 out of 62,709

Cannabis use, depression and self-harm: phenotypic and genetic relationships

• Downloaded 472 times
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  • Site-wide: 20,542 out of 62,709
  • In genetics: 1,379 out of 3,561
• Year to date:
  • Site-wide: 5,374 out of 62,709
• Since beginning of last month:
  • Site-wide: 13,317 out of 62,709

The Maudsley Environmental Risk Score for Psychosis

• Downloaded 442 times
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  • Site-wide: 22,233 out of 62,709
  • In epidemiology: 301 out of 1,556
• Year to date:
  • Site-wide: 15,891 out of 62,709
• Since beginning of last month:
  • Site-wide: 27,556 out of 62,709

Polygenic risk scores for major depressive disorder and neuroticism as predictors of antidepressant response: meta-analysis of three treatment cohorts.

• Downloaded 332 times
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  • Site-wide: 29,951 out of 62,709
  • In genetics: 1,907 out of 3,561
• Year to date:
  • Site-wide: 46,760 out of 62,709
• Since beginning of last month:
  • Site-wide: 34,372 out of 62,709

Predictors of intestinal inflammation in asymptomatic first-degree relatives of patients with Crohn's disease

• Downloaded 289 times
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  • Site-wide: 33,933 out of 62,709
  • In epidemiology: 543 out of 1,556
• Year to date:
  • Site-wide: 59,167 out of 62,709
• Since beginning of last month:
  • Site-wide: 53,073 out of 62,709

Genetic variation in the Major Histocompatibility Complex and association with depression

• Downloaded 282 times
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  • Site-wide: 34,588 out of 62,709
  • In genetics: 2,167 out of 3,561
• Year to date:
  • Site-wide: 27,913 out of 62,709
• Since beginning of last month:
  • Site-wide: 50,736 out of 62,709

Cannabis-associated symptom profiles in patients with first episode psychosis and population controls

• Downloaded 265 times
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  • Site-wide: 36,445 out of 62,709
  • In neuroscience: 6,303 out of 11,193
• Year to date:
  • Site-wide: 13,610 out of 62,709
• Since beginning of last month:
  • Site-wide: 25,238 out of 62,709

Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: meta-analysis of data from genome-wide association studies

• Downloaded 256 times
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  • Site-wide: 37,373 out of 62,709
  • In genetics: 2,303 out of 3,561
• Year to date:
  • Site-wide: 45,444 out of 62,709
• Since beginning of last month:
  • Site-wide: 34,353 out of 62,709

Identifying Potential Causal Risk Factors for Self-Harm: A Polygenic Risk Scoring and Mendelian Randomisation Approach

• Downloaded 219 times
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  • Site-wide: 41,651 out of 62,709
  • In epidemiology: 755 out of 1,556
• Year to date:
  • Site-wide: 17,701 out of 62,709
• Since beginning of last month:
  • Site-wide: 7,225 out of 62,709