Author: Qi Liu

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Preprints

Transmission of corona virus disease 2019 during the incubation period may lead to a quarantine loophole

• Downloaded 5,688 times
• Download rankings, all-time:
  • Site-wide: 2,593
  • In epidemiology: 296
• Year to date:
  • Site-wide: 24,035
• Since beginning of last month:
  • Site-wide: 16,646

Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers

• Downloaded 2,776 times
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  • Site-wide: 7,096
  • In systems biology: 103
• Year to date:
  • Site-wide: 35,238
• Since beginning of last month:
  • Site-wide: 77,342

X-MOL: large-scale pre-training for molecular understanding and diverse molecular analysis

• Downloaded 2,643 times
• Download rankings, all-time:
  • Site-wide: 7,636
  • In bioinformatics: 969
• Year to date:
  • Site-wide: 3,916
• Since beginning of last month:
  • Site-wide: 5,372

Human colorectal pre-cancer atlas identifies distinct molecular programs underlying two major subclasses of pre-malignant tumors

• Downloaded 2,040 times
• Download rankings, all-time:
  • Site-wide: 11,202
  • In cancer biology: 217
• Year to date:
  • Site-wide: 8,079
• Since beginning of last month:
  • Site-wide: 9,923

Cytotoxicity evaluation of chloroquine and hydroxychloroquine in multiple cell lines and tissues by dynamic imaging system and PBPK model

• Downloaded 1,889 times
• Download rankings, all-time:
  • Site-wide: 12,552
  • In pharmacology and toxicology: 71
• Year to date:
  • Site-wide: 61,604
• Since beginning of last month:
  • Site-wide: 30,696

Cancer Hallmarks Define a Continuum of Plastic Cell States between Small Cell Lung Cancer Archetypes

• Downloaded 1,644 times
• Download rankings, all-time:
  • Site-wide: 15,384
  • In systems biology: 281
• Year to date:
  • Site-wide: 9,018
• Since beginning of last month:
  • Site-wide: 13,324

METTL5, an 18S rRNA-specific m6A methyltransferase, modulates expression of stress response genes

• Downloaded 1,470 times
• Download rankings, all-time:
  • Site-wide: 18,232
  • In biochemistry: 405
• Year to date:
  • Site-wide: 26,165
• Since beginning of last month:
  • Site-wide: 17,384

Ongoing natural selection drives the evolution of SARS-CoV-2 genomes

• Downloaded 1,465 times
• Download rankings, all-time:
  • Site-wide: 18,329
  • In epidemiology: 1,206
• Year to date:
  • Site-wide: 65,965
• Since beginning of last month:
  • Site-wide: 83,193

FL-QSAR: a federated learning based QSAR prototype for collaborative drug discovery

• Downloaded 1,257 times
• Download rankings, all-time:
  • Site-wide: 23,231
  • In bioinformatics: 2,642
• Year to date:
  • Site-wide: 22,812
• Since beginning of last month:
  • Site-wide: 17,946

Commensal-derived succinate enhances tuft cell specification and suppresses ileal inflammation

• Downloaded 1,114 times
• Download rankings, all-time:
  • Site-wide: 28,005
  • In cell biology: 964
• Year to date:
  • Site-wide: 102,644
• Since beginning of last month:
  • Site-wide: 109,067

RNA G-quadruplex structures exist and function in vivo

• Downloaded 1,085 times
• Download rankings, all-time:
  • Site-wide: 29,135
  • In plant biology: 440
• Year to date:
  • Site-wide: 102,097
• Since beginning of last month:
  • Site-wide: 80,857

Quantitative assessment of cell population diversity in single-cell landscapes

• Downloaded 1,029 times
• Download rankings, all-time:
  • Site-wide: 31,422
  • In bioinformatics: 3,261
• Year to date:
  • Site-wide: 168,170
• Since beginning of last month:
  • Site-wide: 174,437

Biogenesis of RNA-containing extracellular vesicles at endoplasmic reticulum membrane contact sites

• Downloaded 1,009 times
• Download rankings, all-time:
  • Site-wide: 32,362
  • In cell biology: 1,366
• Year to date:
  • Site-wide: 19,056
• Since beginning of last month:
  • Site-wide: 14,182

Intact RNA structurome reveals mRNA structure-mediated regulation of miRNA cleavage in vivo

• Downloaded 971 times
• Download rankings, all-time:
  • Site-wide: 34,273
  • In molecular biology: 881
• Year to date:
  • Site-wide: 126,417
• Since beginning of last month:
  • Site-wide: 141,494

Dual indexed design of in-Drop single-cell RNA-seq libraries improves sequencing quality and throughput

• Downloaded 852 times
• Download rankings, all-time:
  • Site-wide: 41,533
  • In molecular biology: 1,115
• Year to date:
  • Site-wide: 97,603
• Since beginning of last month:
  • Site-wide: 47,662

Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism

• Downloaded 828 times
• Download rankings, all-time:
  • Site-wide: 43,329
  • In biochemistry: 1,058
• Year to date:
  • Site-wide: 94,797
• Since beginning of last month:
  • Site-wide: 68,864

ProGeo-neo: a Customized Proteogenomic Workflow for Neoantigen Prediction and Selection

• Downloaded 706 times
• Download rankings, all-time:
  • Site-wide: 54,398
  • In bioinformatics: 5,377
• Year to date:
  • Site-wide: 74,874
• Since beginning of last month:
  • Site-wide: 44,939

Identifying Lineage-specific Targets of Darwinian Selection by a Bayesian Analysis of Genomic Polymorphisms and Divergence from Multiple Species

• Downloaded 690 times
• Download rankings, all-time:
  • Site-wide: 56,035
  • In genomics: 3,948
• Year to date:
  • Site-wide: 167,713
• Since beginning of last month:
  • Site-wide: 171,968

Unexpected CRISPR off-target mutation pattern in vivo are not typically germline-like

• Downloaded 619 times
• Download rankings, all-time:
  • Site-wide: 64,806
  • In genetics: 2,509
• Year to date:
  • Site-wide: 185,945
• Since beginning of last month:
  • Site-wide: 180,161

Characterizing cellular and molecular variabilities of peripheral immune cells in healthy inactivated SARS-CoV-2 vaccine recipients by single-cell RNA sequencing

• Downloaded 598 times
• Download rankings, all-time:
  • Site-wide: 67,784
  • In infectious diseases: 4,196
• Year to date:
  • Site-wide: 39,024
• Since beginning of last month:
  • Site-wide: 21,803

PAX3-FOXO1 coordinates enhancer architecture, eRNA transcription, andRNA polymerase pause release at select gene targets

• Downloaded 598 times
• Download rankings, all-time:
  • Site-wide: 67,783
  • In molecular biology: 2,353
• Year to date:
  • Site-wide: 9,895
• Since beginning of last month:
  • Site-wide: 18,384

A Genetically Encoded Trimethylsilyl 1D 1H-NMR Probe for Conformation Change in Large Membrane Protein Complexes

• Downloaded 580 times
• Download rankings, all-time:
  • Site-wide: 70,479
  • In biochemistry: 1,824
• Year to date:
  • Site-wide: 132,159
• Since beginning of last month:
  • Site-wide: 85,974

In vivo nuclear RNA structurome reveals RNA-structure regulation of mRNA processing in plants

• Downloaded 567 times
• Download rankings, all-time:
  • Site-wide: 72,358
  • In plant biology: 1,653
• Year to date:
  • Site-wide: 183,026
• Since beginning of last month:
  • Site-wide: 168,957

Subjugation of TGFβ Signaling by Human Papilloma Virus in Head and Neck Squamous Cell Carcinoma Shifts DNA Repair from Homologous Recombination to Alternative End-Joining

• Downloaded 490 times
• Download rankings, all-time:
  • Site-wide: 85,976
  • In cancer biology: 2,533
• Year to date:
  • Site-wide: 98,741
• Since beginning of last month:
  • Site-wide: 45,089

Scalable and model-free detection of spatial patterns and colocalization

• Downloaded 460 times
• Download rankings, all-time:
  • Site-wide: 92,199
  • In bioinformatics: None
• Year to date:
  • Site-wide: 4,162
• Since beginning of last month:
  • Site-wide: 616

MYC regulates ribosome biogenesis and mitochondrial gene expression programs through interaction with Host Cell Factor-1

• Downloaded 426 times
• Download rankings, all-time:
  • Site-wide: 99,794
  • In cancer biology: 2,979
• Year to date:
  • Site-wide: 90,710
• Since beginning of last month:
  • Site-wide: 61,927

Surface texture limits transfer of S. aureus, T4 Bacteriophage, Influenza B virus and Human coronavirus.

• Downloaded 419 times
• Download rankings, all-time:
  • Site-wide: 101,448
  • In infectious diseases: 5,148
• Year to date:
  • Site-wide: 62,947
• Since beginning of last month:
  • Site-wide: 58,983

A Chemical-genetics and Nanoparticle Enabled Approach for in vivo Protein Kinase Analysis

• Downloaded 401 times
• Download rankings, all-time:
  • Site-wide: 105,710
  • In cell biology: 4,980
• Year to date:
  • Site-wide: 58,837
• Since beginning of last month:
  • Site-wide: 109,498

The Hippo pathway regulates density-dependent proliferation of iPSC-derived cardiac myocytes

• Downloaded 398 times
• Download rankings, all-time:
  • Site-wide: 106,352
  • In cell biology: 5,043
• Year to date:
  • Site-wide: 59,960
• Since beginning of last month:
  • Site-wide: 50,117

AIM-SNPtag: a computationally efficient approach for developing ancestry-informative SNP panels

• Downloaded 389 times
• Download rankings, all-time:
  • Site-wide: 108,779
  • In bioinformatics: 8,893
• Year to date:
  • Site-wide: 95,587
• Since beginning of last month:
  • Site-wide: 100,259

Prostatic osteopontin expression is associated with symptomatic benign prostatic hyperplasia

• Downloaded 387 times
• Download rankings, all-time:
  • Site-wide: 109,078
  • In pathology: 536
• Year to date:
  • Site-wide: 163,826
• Since beginning of last month:
  • Site-wide: 165,779

Spermidine and spermine are the natural substrates of the Acinetobacter baumannii AmvA multidrug efflux pump

• Downloaded 378 times
• Download rankings, all-time:
  • Site-wide: 111,423
  • In microbiology: 7,592
• Year to date:
  • Site-wide: 97,975
• Since beginning of last month:
  • Site-wide: 133,576

Plant DNA polymerases alpha and delta mediate replication of geminiviruses

• Downloaded 366 times
• Download rankings, all-time:
  • Site-wide: 114,605
  • In plant biology: 2,934
• Year to date:
  • Site-wide: 151,082
• Since beginning of last month:
  • Site-wide: 121,604

Genome-wide association studies reveal novel locus with sex-/therapy-specific fracture risk effects in childhood cancer survivors

• Downloaded 362 times
• Download rankings, all-time:
  • Site-wide: 115,709
  • In genetic and genomic medicine: 690
• Year to date:
  • Site-wide: 78,283
• Since beginning of last month:
  • Site-wide: 88,933

Quantifying and correcting slide-to-slide variation in multiplexed immunofluorescence images

• Downloaded 358 times
• Download rankings, all-time:
  • Site-wide: 116,814
  • In bioinformatics: 9,388
• Year to date:
  • Site-wide: 89,951
• Since beginning of last month:
  • Site-wide: 117,520

High-throughput tandem-microwell assay for ammonia repositions FDA-Approved drugs to Helicobacter pylori infection

• Downloaded 342 times
• Download rankings, all-time:
  • Site-wide: 121,235
  • In biochemistry: 3,893
• Year to date:
  • Site-wide: 41,061
• Since beginning of last month:
  • Site-wide: 24,803

Neural Correlates of Positive and Negative Valence System Dysfunction in Adolescents Revealed by Data-Driven Parcellation and Resting-State Network Modeling

• Downloaded 306 times
• Download rankings, all-time:
  • Site-wide: 131,258
  • In neuroscience: 18,808
• Year to date:
  • Site-wide: 149,730
• Since beginning of last month:
  • Site-wide: 165,273

Enabling in vivo Analysis Via Nanoparticle-mediated Intracellular Assay Probe Delivery: Using RAS as the Prototype

• Downloaded 304 times
• Download rankings, all-time:
  • Site-wide: 131,999
  • In biochemistry: 3,886
• Year to date:
  • Site-wide: 72,025
• Since beginning of last month:
  • Site-wide: 61,989

Synergistic interplay between PHF8 and HER2 signaling contributes to breast cancer development and drug resistance

• Downloaded 283 times
• Download rankings, all-time:
  • Site-wide: 138,033
  • In cancer biology: 4,052
• Year to date:
  • Site-wide: 160,059
• Since beginning of last month:
  • Site-wide: 125,219

Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1

• Downloaded 230 times
• Download rankings, all-time:
  • Site-wide: 153,494
  • In biochemistry: 4,563
• Year to date:
  • Site-wide: 96,717
• Since beginning of last month:
  • Site-wide: 83,054

Estimating Excess Mortality Following Pediatric and Adolescent Cancer in the U.S.

• Downloaded 179 times
• Download rankings, all-time:
  • Site-wide: 167,037
  • In epidemiology: 6,608
• Year to date:
  • Site-wide: 179,430
• Since beginning of last month:
  • Site-wide: 175,855

Dr. Sim: Similarity Learning for Transcriptional Phenotypic Drug discovery

• Downloaded 119 times
• Download rankings, all-time:
  • Site-wide: 179,081
  • In bioinformatics: 12,825
• Year to date:
  • Site-wide: 83,667
• Since beginning of last month:
  • Site-wide: 92,368

Cyclin G2 inhibits oral squamous cell carcinoma growth and metastasis by binding to insulin-like growth factor binding protein 3 and regulating the FAK-SRC-STAT signaling pathway

• Downloaded 109 times
• Download rankings, all-time:
  • Site-wide: 180,633
  • In cancer biology: 5,336
• Year to date:
  • Site-wide: 157,445
• Since beginning of last month:
  • Site-wide: 140,030