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Author: Howard Y. Chang

  • Most recently observed institution: Howard Hughes Medical Institute, Stanford University

Rankings

  • All-time downloads: 84,916 (rank: 418 out of 384,409)
  • Categories:
    • bioinformatics: 2,198 (rank: 4,853 out of 32,898)
    • cancer biology: 1,279 (rank: 3,477 (tie) out of 26,474)
    • cell biology: 10,271 (rank: 236 out of 28,533)
    • evolutionary biology: 1,576 (rank: 2,630 (tie) out of 19,684)
    • genetics: 939 (rank: 13,475 (tie) out of 35,509)
    • genomics: 51,813 (rank: 123 out of 40,840)
    • immunology: 7,841 (rank: 361 out of 20,921)
    • molecular biology: 6,642 (rank: 251 out of 19,968)
    • neuroscience: 2,357 (rank: 6,382 (tie) out of 64,401)

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Preprints

Human B cell clonal expansion and convergent antibody responses to SARS-CoV-2

immunology more details view paper

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KLF4 Recruits SWI/SNF to Increase Chromatin Accessibility and Reprogram the Endothelial Enhancer Landscape under Laminar Shear Stress

molecular biology more details view paper

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Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion

genomics more details view paper
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Atlas of Subcellular RNA Localization Revealed by APEX-seq

cell biology more details view paper
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    • In cell biology: 7 out of 4,602
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Clonal replacement of tumor-specific T cells following PD-1 blockade

immunology more details view paper
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    • In immunology: 15 out of 2,589
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Single-cell epigenomics maps the continuous regulatory landscape of human hematopoietic differentiation

genomics more details view paper
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    • In genomics: 133 out of 5,709
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Genetic determinants of co-accessible chromatin regions in T cell activation across humans

genomics more details view paper
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    • In genomics: 162 out of 5,709
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A single cell framework for multi-omic analysis of disease identifies malignant regulatory signatures in mixed phenotype acute leukemia

genomics more details view paper
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Coupled single-cell CRISPR screening and epigenomic profiling reveals causal gene regulatory networks

genomics more details view paper
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    • In genomics: 213 out of 5,709
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An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

genomics more details view paper
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    • In genomics: 230 out of 5,709
  • Year to date:
    • Site-wide: 9,566 out of 89,715
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    • Site-wide: 21,092 out of 89,715

Single-cell epigenomic identification of inherited risk loci in Alzheimer's and Parkinson's disease

genomics more details view paper
  • Downloaded 3,651 times
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    • In genomics: 285 out of 5,709
  • Year to date:
    • Site-wide: 284 out of 89,715
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    • Site-wide: 822 out of 89,715

Super-resolution Imaging Reveals 3D Structure and Organizing Mechanism of Accessible Chromatin

molecular biology more details view paper
  • Downloaded 3,124 times
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    • In molecular biology: 52 out of 3,044
  • Year to date:
    • Site-wide: 3,170 out of 89,715
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    • Site-wide: 6,814 out of 89,715

Enhancer connectome in primary human cells reveals target genes of disease-associated DNA elements

genomics more details view paper
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    • In genomics: 369 out of 5,709
  • Year to date:
    • Site-wide: 36,107 out of 89,715
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    • Site-wide: 58,351 out of 89,715

ArchR: An integrative and scalable software package for single-cell chromatin accessibility analysis

genomics more details view paper
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    • Site-wide: 2,241 out of 89,715
    • In genomics: 431 out of 5,709
  • Year to date:
    • Site-wide: 400 out of 89,715
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    • Site-wide: 418 out of 89,715

HiChIP: Efficient and sensitive analysis of protein-directed genome architecture

genomics more details view paper
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    • Site-wide: 2,405 out of 89,715
    • In genomics: 456 out of 5,709
  • Year to date:
    • Site-wide: 62,954 out of 89,715
  • Since beginning of last month:
    • Site-wide: 72,481 out of 89,715

Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity

genomics more details view paper
  • Downloaded 2,349 times
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    • Site-wide: 2,828 out of 89,715
    • In genomics: 539 out of 5,709
  • Year to date:
    • Site-wide: 16,903 out of 89,715
  • Since beginning of last month:
    • Site-wide: 21,826 out of 89,715

Dynamic Regulation of RNA Structure in Mammalian Cells

molecular biology more details view paper
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    • Site-wide: 3,851 out of 89,715
    • In molecular biology: 123 out of 3,044
  • Year to date:
    • Site-wide: 19,487 out of 89,715
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    • Site-wide: 26,305 out of 89,715

Transient "rest" induces functional reinvigoration and epigenetic remodeling in exhausted CAR-T cells

immunology more details view paper
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    • Site-wide: 4,203 out of 89,715
    • In immunology: 111 out of 2,589
  • Year to date:
    • Site-wide: 618 out of 89,715
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    • Site-wide: 2,205 out of 89,715

Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNA

genomics more details view paper
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    • Site-wide: 4,387 out of 89,715
    • In genomics: 745 out of 5,709
  • Year to date:
    • Site-wide: 30,113 out of 89,715
  • Since beginning of last month:
    • Site-wide: 33,459 out of 89,715

Evolutionary dynamics of roX lncRNA function and genomic occupancy

evolutionary biology more details view paper
  • Downloaded 1,576 times
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    • Site-wide: 5,438 out of 89,715
    • In evolutionary biology: 254 out of 5,480
  • Year to date:
    • Site-wide: 84,493 out of 89,715
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    • Site-wide: 80,725 out of 89,715

Frequent extrachromosomal oncogene amplification drives aggressive tumors

cancer biology more details view paper
  • Downloaded 1,279 times
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    • Site-wide: 7,685 out of 89,715
    • In cancer biology: 207 out of 3,170
  • Year to date:
    • Site-wide: 2,781 out of 89,715
  • Since beginning of last month:
    • Site-wide: 5,578 out of 89,715

Cerebellar nuclei evolved by repeatedly duplicating a conserved cell type set

neuroscience more details view paper
  • Downloaded 976 times
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    • In neuroscience: 1,898 out of 15,954
  • Year to date:
    • Site-wide: 1,539 out of 89,715
  • Since beginning of last month:
    • Site-wide: 194 out of 89,715

Functional classification of noncoding RNAs associated with distinct histone modifications by PIRCh-seq

cell biology more details view paper
  • Downloaded 908 times
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    • Site-wide: 13,458 out of 89,715
    • In cell biology: 555 out of 4,602
  • Year to date:
    • Site-wide: 20,322 out of 89,715
  • Since beginning of last month:
    • Site-wide: 20,904 out of 89,715

Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons

neuroscience more details view paper
  • Downloaded 896 times
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    • Site-wide: 13,741 out of 89,715
    • In neuroscience: 2,203 out of 15,954
  • Year to date:
    • Site-wide: 18,027 out of 89,715
  • Since beginning of last month:
    • Site-wide: 8,291 out of 89,715

Structural modularity of the XIST ribonucleoprotein complex

molecular biology more details view paper
  • Downloaded 895 times
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    • In molecular biology: 443 out of 3,044
  • Year to date:
    • Site-wide: 8,665 out of 89,715
  • Since beginning of last month:
    • Site-wide: 12,067 out of 89,715

RNA-GPS Predicts SARS-CoV-2 RNA Localization to Host Mitochondria and Nucleolus

bioinformatics more details view paper
  • Downloaded 856 times
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    • Site-wide: 14,734 out of 89,715
    • In bioinformatics: 2,284 out of 8,461
  • Year to date:
    • Site-wide: 1,869 out of 89,715
  • Since beginning of last month:
    • Site-wide: 984 out of 89,715

Feedback Regulation between Initiation and Maturation Networks Orchestrates the Chromatin Dynamics of Epidermal Lineage Commitment

cell biology more details view paper
  • Downloaded 736 times
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    • In cell biology: 800 out of 4,602
  • Year to date:
    • Site-wide: 42,650 out of 89,715
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    • Site-wide: 32,030 out of 89,715

CRISPRpic: Fast and precise analysis for CRISPR-induced mutations via prefixed index counting

bioinformatics more details view paper
  • Downloaded 695 times
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    • Site-wide: 20,263 out of 89,715
    • In bioinformatics: 2,940 out of 8,461
  • Year to date:
    • Site-wide: 48,225 out of 89,715
  • Since beginning of last month:
    • Site-wide: 45,528 out of 89,715

Satb1 integrates DNA sequence, shape, motif density and torsional stress to differentially bind targets in nucleosome-dense regions.

molecular biology more details view paper
  • Downloaded 678 times
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    • Site-wide: 20,982 out of 89,715
    • In molecular biology: 674 out of 3,044
  • Year to date:
    • Site-wide: 43,930 out of 89,715
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    • Site-wide: 62,515 out of 89,715

Integrative analysis of single cell genomics data by coupled nonnegative matrix factorizations

bioinformatics more details view paper
  • Downloaded 647 times
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    • Site-wide: 22,445 out of 89,715
    • In bioinformatics: 3,189 out of 8,461
  • Year to date:
    • Site-wide: 56,871 out of 89,715
  • Since beginning of last month:
    • Site-wide: 46,304 out of 89,715

Exploring the role of Polycomb recruitment in Xist-mediated silencing of the X chromosome in ES cells

genetics more details view paper
  • Downloaded 606 times
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    • In genetics: 1,526 out of 4,631
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    • Site-wide: 53,833 out of 89,715

Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation

genomics more details view paper
  • Downloaded 593 times
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    • Site-wide: 25,436 out of 89,715
    • In genomics: 2,767 out of 5,709
  • Year to date:
    • Site-wide: 5,033 out of 89,715
  • Since beginning of last month:
    • Site-wide: 33,496 out of 89,715

The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders

neuroscience more details view paper
  • Downloaded 485 times
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    • Site-wide: 32,785 out of 89,715
    • In neuroscience: 5,591 out of 15,954
  • Year to date:
    • Site-wide: 72,839 out of 89,715
  • Since beginning of last month:
    • Site-wide: 82,337 out of 89,715

Morphogen-Lineage Selector Interactions During Surface Epithelial Commitment

genetics more details view paper
  • Downloaded 333 times
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    • Site-wide: 48,871 out of 89,715
    • In genetics: 2,791 out of 4,631
  • Year to date:
    • Site-wide: 77,704 out of 89,715
  • Since beginning of last month:
    • Site-wide: 67,733 out of 89,715

Integrative profiling of early host chromatin accessibility responses in human neutrophils with sensitive pathogen detection.

immunology more details view paper
  • Downloaded 119 times
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    • Site-wide: 81,788 out of 89,715
    • In immunology: 2,308 out of 2,589
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  • Since beginning of last month:
    • Site-wide: 33,180 out of 89,715

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