Author: Pradeep Natarajan

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Preprints

Analysis of protein-coding genetic variation in 60,706 humans

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  • Site-wide: 291
  • In genomics: 11
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  • Site-wide: 47,434
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  • Site-wide: None

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

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  • Site-wide: 990
  • In genomics: 93
• Year to date:
  • Site-wide: 1,366
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  • Site-wide: 1,263

Genome-wide polygenic score to identify a monogenic risk-equivalent for coronary disease

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  • Site-wide: 1,935
  • In genomics: 206
• Year to date:
  • Site-wide: 35,731
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  • Site-wide: 43,660

Androgen regulates SARS-CoV-2 receptor levels and is associated with severe COVID-19 symptoms in men

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  • Site-wide: 2,202
  • In cell biology: 40
• Year to date:
  • Site-wide: 4,903
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  • Site-wide: 5,141

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

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  • Site-wide: 4,294
  • In genomics: 494
• Year to date:
  • Site-wide: 6,966
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  • Site-wide: 7,105

A statistical framework for cross-tissue transcriptome-wide association analysis

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  • Site-wide: 4,335
  • In genetics: 199
• Year to date:
  • Site-wide: 38,481
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  • Site-wide: 31,864

Human knockouts in a cohort with a high rate of consanguinity

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  • Site-wide: 4,940
  • In genomics: 577
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Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

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  • Site-wide: 5,711
  • In genetics: 272
• Year to date:
  • Site-wide: 91,983
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  • Site-wide: 60,318

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

• Downloaded 2,088 times
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  • Site-wide: 6,521
  • In genomics: 742
• Year to date:
  • Site-wide: 111,699
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  • Site-wide: 93,798

Genetic predisposition to myeloproliferative neoplasms implicates hematopoietic stem cell biology

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  • Site-wide: 15,078
  • In genetics: 775
• Year to date:
  • Site-wide: 20,194
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  • Site-wide: 14,119

Proteomic Profiling in Biracial Cohorts Implicates DC-SIGN as a Mediator of Genetic Risk in COVID-19

• Downloaded 1,164 times
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  • Site-wide: 15,653
  • In infectious diseases: 1,418
• Year to date:
  • Site-wide: 14,255
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  • Site-wide: 13,680

Heart Rate Variability with Photoplethysmography in 8 Million Individuals: Results and Scaling Relations with Age, Gender, and Time of Day

• Downloaded 888 times
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  • Site-wide: 23,346
  • In physiology: 87
• Year to date:
  • Site-wide: 18,000
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  • Site-wide: 16,727

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

• Downloaded 755 times
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  • Site-wide: 29,283
  • In genetics: 1,452
• Year to date:
  • Site-wide: 118,105
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  • Site-wide: 74,319

Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

• Downloaded 739 times
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  • Site-wide: 30,097
  • In genomics: 2,748
• Year to date:
  • Site-wide: 50,587
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  • Site-wide: 59,076

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

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  • Site-wide: 30,256
  • In genomics: 2,757
• Year to date:
  • Site-wide: 90,729
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  • Site-wide: 83,241

Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer

• Downloaded 683 times
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  • Site-wide: 33,544
  • In genetic and genomic medicine: 97
• Year to date:
  • Site-wide: 4,697
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  • Site-wide: 7,497

Influence of blood pressure on pneumonia risk: Epidemiological association and Mendelian randomisation in the UK Biobank

• Downloaded 561 times
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  • Site-wide: 43,268
  • In genetic and genomic medicine: 120
• Year to date:
  • Site-wide: 62,527
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  • Site-wide: 68,970

Genetic Association of Arterial Stiffness Index with Blood Pressure and Coronary Artery Disease

• Downloaded 518 times
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  • Site-wide: 47,609
  • In bioinformatics: 4,997
• Year to date:
  • Site-wide: 52,714
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  • Site-wide: 74,433

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

• Downloaded 504 times
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  • Site-wide: 49,207
  • In genetics: 2,353
• Year to date:
  • Site-wide: 3,660
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  • Site-wide: None

Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease

• Downloaded 403 times
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  • Site-wide: 62,457
  • In genetics: 2,951
• Year to date:
  • Site-wide: 69,243
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  • Site-wide: 84,679

Increased CHIP Prevalence Amongst People Living with HIV

• Downloaded 367 times
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  • Site-wide: 68,271
  • In genetic and genomic medicine: 203
• Year to date:
  • Site-wide: 16,066
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  • Site-wide: 9,825

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 286 times
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  • Site-wide: 83,221
  • In genetics: 3,836
• Year to date:
  • Site-wide: 27,151
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  • Site-wide: 39,126

Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study

• Downloaded 282 times
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  • Site-wide: 84,062
  • In cardiovascular medicine: 131
• Year to date:
  • Site-wide: 50,917
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  • Site-wide: 68,701

Genome-Wide Screening Reveals CSDE1 as a Novel Regulator of the LDL Receptor

• Downloaded 273 times
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  • Site-wide: 86,008
  • In genomics: 5,487
• Year to date:
  • Site-wide: 41,505
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  • Site-wide: 34,010

Assessment and Utilization of Patient-Reported Outcomes Measures to Improve Cardiovascular Disease Prevention

• Downloaded 226 times
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  • Site-wide: 96,031
  • In cardiovascular medicine: 171
• Year to date:
  • Site-wide: 48,206
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  • Site-wide: 102,994

Clinical conditions and their impact on utility of genetic scores for prediction of acute coronary syndrome

• Downloaded 186 times
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  • Site-wide: 104,854
  • In cardiovascular medicine: 210
• Year to date:
  • Site-wide: 72,547
• Since beginning of last month:
  • Site-wide: 58,229

Genetic Variation in Blood Pressure and Lifetime Risk of Peripheral Artery Disease: A Mendelian Randomization Study

• Downloaded 165 times
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  • Site-wide: 109,101
  • In cardiovascular medicine: 235
• Year to date:
  • Site-wide: 55,190
• Since beginning of last month:
  • Site-wide: 102,261

Prospective evaluation of genome sequencing versus standard-of-care as a first molecular diagnostic test

• Downloaded 145 times
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  • Site-wide: 112,950
  • In genetic and genomic medicine: 490
• Year to date:
  • Site-wide: 97,504
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  • Site-wide: 72,225

OUTCOMES OF A SMARTPHONE-BASED APPLICATION WITH LIVE HEALTH-COACHING POST-PERCUTANEOUS CORONARY INTERVENTION

• Downloaded 114 times
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  • Site-wide: 118,757
  • In cardiovascular medicine: 295
• Year to date:
  • Site-wide: 54,259
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  • Site-wide: 72,510