Author: John Kenneth Baillie

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Preprints

An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients

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Effect of Dexamethasone in Hospitalized Patients with COVID-19: Preliminary Report

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Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol

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  • Site-wide: 78
  • In infectious diseases: 27
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Effect of Hydroxychloroquine in Hospitalized Patients with COVID-19: Preliminary results from a multi-centre, randomized, controlled trial.

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  • Site-wide: 221
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Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

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Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): preliminary results of a randomised, controlled, open-label, platform trial

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Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

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Genetic mechanisms of critical illness in Covid-19

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Physical, cognitive and mental health impacts of COVID-19 following hospitalisation: a multi-centre prospective cohort study

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  • Site-wide: 1,166
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Tissue-specific tolerance in fatal Covid-19

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ISARIC COVID-19 Clinical Data Report: 27 March 2022

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Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients.

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Neutralising antibodies to SARS coronavirus 2 in Scottish blood donors - a pilot study of the value of serology to determine population exposure

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Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19

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An adaptive randomized controlled trial of non-invasive respiratory strategies in acute respiratory failure patients with COVID-19

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Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

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Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis

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  • Site-wide: 2,289
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Azithromycin in Hospitalised Patients with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

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A blood atlas of COVID-19 defines hallmarks of disease severity and specificity

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  • Site-wide: 3,562
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Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

• Downloaded 4,357 times
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  • Site-wide: 3,796
  • In infectious diseases: 844
• Year to date:
  • Site-wide: 21,321
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  • Site-wide: 21,925

Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

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  • Site-wide: 4,316
  • In infectious diseases: 935
• Year to date:
  • Site-wide: 9,270
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Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol.

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  • Site-wide: 5,554
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  • Site-wide: 12,156
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  • Site-wide: 7,728

Functional Annotation of Human Long Non-Coding RNAs via Molecular Phenotyping

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  • Site-wide: 6,815
  • In genomics: 625
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  • Site-wide: 69,650
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  • Site-wide: 56,882

SARS-CoV-2 RNA detected in blood samples from patients with COVID-19 is not associated with infectious virus

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  • Site-wide: 7,158
  • In infectious diseases: 1,251
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  • Site-wide: 102,921

Outcome of hospitalisation for COVID-19 in patients with Interstitial Lung Disease: An international multicentre study.

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  • Site-wide: 7,805
  • In respiratory medicine: 31
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  • Site-wide: 99,597
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  • Site-wide: 118,427

A common TMPRSS2 variant protects against severe COVID-19

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  • Site-wide: 9,712
  • In genetic and genomic medicine: 49
• Year to date:
  • Site-wide: 11,833
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  • Site-wide: 12,744

Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease.

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  • Site-wide: 9,943
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  • Site-wide: 169,424

Whole genome sequencing identifies multiple loci for critical illness caused by COVID-19

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  • Site-wide: 10,567
  • In intensive care and critical care medicine: 52
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Multiomic definition of generalizable endotypes in human acute pancreatitis

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Elevated antiviral, myeloid and endothelial inflammatory markers in severe COVID-19

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  • Site-wide: 14,064
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• Year to date:
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  • Site-wide: 60,105

Clinical characteristics of children and young people hospitalised with covid-19 in the United Kingdom: prospective multicentre observational cohort study

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  • Site-wide: 16,222
  • In pediatrics: 39
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  • Site-wide: 74,669
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  • Site-wide: 78,570

Sequence analysis of SARS-CoV-2 in nasopharyngeal samples from patients with COVID-19 illustrates population variation and diverse phenotypes, placing the in vitro growth properties of B.1.1.7 and B.1.351 lineage viruses in context.

• Downloaded 1,589 times
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  • Site-wide: 16,690
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Outcomes of COVID-19 related hospitalisation among people with HIV in the ISARIC WHO Clinical Characterisation Protocol UK Protocol: prospective observational study

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  • Site-wide: 18,367
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  • Site-wide: 17,672
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Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19

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  • Site-wide: 21,744
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  • Site-wide: 3,838

Proteome-by-phenome Mendelian Randomisation detects 38 proteins with causal roles in human diseases and traits

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  • Site-wide: 173,220

Robust, reproducible clinical patterns in hospitalised patients with COVID-19

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Short-term forecasts to inform the response to the COVID-19 epidemic in the UK

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  • Site-wide: 24,810
  • In epidemiology: 1,576
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Systematic review and meta-analysis identifies potential host therapeutic targets in COVID-19.

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Evaluation of the effectiveness of remdesivir in severe COVID-19 using observational data from a prospective national cohort study

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Development and validation of the 4C Deterioration model for adults hospitalised with COVID-19

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  • In infectious diseases: 2,671
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What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? - A harmonised, global longitudinal observational study

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  • Site-wide: 29,935
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Endomembrane targeting of human OAS1 p46 augments antiviral activity

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Upstream translation initiation expands the coding capacity of segmented negative-strand RNA viruses

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Secreted SARS-CoV-2 ORF8 modulates the cytokine expression profile of human macrophages

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Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score

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Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.

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Pandemic, epidemic, endemic: B cell repertoire analysis reveals unique anti-viral responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus

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Comparison of children and young people admitted with SARS-CoV-2 across the UK in the first and second pandemic waves: prospective multicentre observational cohort study

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Comprehensive characterisation of molecular host-pathogen interactions in influenza A virus-infected human macrophages

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Rapid selection of P323L in the SARS-CoV-2 polymerase (NSP12) in humans and non-human primate models and confers a large plaque phenotype

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Subtractive CRISPR screen identifies factors involved in non-canonical LC3 lipidation.

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Shared genetic etiology between idiopathic pulmonary fibrosis and COVID-19 severity

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Recovery from Covid-19 critical illness: a secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial

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GWAS and meta-analysis identifies multiple new genetic mechanisms underlying severe Covid-19.

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  • Site-wide: 9,765

Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative

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SARS-CoV-2 environmental contamination from hospitalised COVID-19 patients receiving aerosol generating procedures

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Predictive validity of effective shunt fraction in critically ill patients

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Changes in UK hospital mortality in the first wave of COVID-19: the ISARIC WHO Clinical Characterisation Protocol prospective multicentre observational cohort study

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Genetic control of KRAB-ZFP genes explains distal CpG-site methylation which associates with human disease phenotypes.

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Systematic comparison of ranking aggregation methods for gene lists in experimental results

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Characterising pre-clinical sub-phenotypic models of Acute Respiratory Distress Syndrome: an experimental ovine study.

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Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence

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