Author: Andre Franke

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Preprints

The ABO blood group locus and a chromosome 3 gene cluster associate with SARS-CoV-2 respiratory failure in an Italian-Spanish genome-wide association analysis

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  • Site-wide: 57
  • In infectious diseases: 20
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  • Site-wide: 429
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  • Site-wide: 443

Pre-existing T cell memory as a risk factor for severe 1 COVID-19 in the elderly

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  • Site-wide: 902
  • In allergy and immunology: 5
• Year to date:
  • Site-wide: 1,890
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  • Site-wide: 3,194

Association mapping of inflammatory bowel disease loci to single variant resolution

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  • Site-wide: 3,152
  • In genetics: 122
• Year to date:
  • Site-wide: 48,662
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  • Site-wide: 40,971

Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data.

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  • Site-wide: 4,141
  • In bioinformatics: 429
• Year to date:
  • Site-wide: 28,756
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  • Site-wide: 36,037

Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection

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  • Site-wide: 4,287
  • In immunology: 121
• Year to date:
  • Site-wide: 4,107
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  • Site-wide: 8,293

Large-scale association analyses identify host factors influencing human gut microbiome composition

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  • Site-wide: 6,663
  • In genetics: 323
• Year to date:
  • Site-wide: 2,902
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Longitudinal multi-omics analysis identifies responses of megakaryocytes, erythroid cells and plasmablasts as hallmarks of severe COVID-19 trajectories

• Downloaded 1,727 times
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  • Site-wide: 9,271
  • In infectious diseases: 1,158
• Year to date:
  • Site-wide: 6,231
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  • Site-wide: 5,947

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population

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  • Site-wide: 11,052
  • In genetics: 533
• Year to date:
  • Site-wide: 119,813
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  • Site-wide: 128,736

Neolithic genomes reveal a distinct ancient HLA allele pool and population transformation in Europe

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  • Site-wide: 11,898
  • In evolutionary biology: 406
• Year to date:
  • Site-wide: 16,129
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  • Site-wide: 17,990

A genome-wide genetic pleiotropy approach identified shared loci between multiple system atrophy and inflammatory bowel disease

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  • Site-wide: 23,778
  • In genetics: 1,155
• Year to date:
  • Site-wide: 77,615
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  • Site-wide: 73,133

Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms

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  • Site-wide: 33,107
  • In microbiology: 1,964
• Year to date:
  • Site-wide: 67,795
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  • Site-wide: 61,123

Arrhythmic gut microbiome signatures for risk profiling of Type-2 Diabetes

• Downloaded 693 times
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  • Site-wide: 34,995
  • In microbiology: 2,081
• Year to date:
  • Site-wide: 23,966
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  • Site-wide: 39,699

Integrating Culture-based Antibiotic Resistance Profiles with Whole-genome Sequencing Data for 11,087 Clinical Isolates

• Downloaded 691 times
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  • Site-wide: 35,119
  • In genomics: 3,049
• Year to date:
  • Site-wide: 85,021
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  • Site-wide: 108,115

ABO histo-blood groups influence gut microbiome, with causal relationship between Bacteroides and inflammatory bowel disease

• Downloaded 680 times
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  • Site-wide: 35,873
  • In gastroenterology: 28
• Year to date:
  • Site-wide: 7,224
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  • Site-wide: 16,219

Comprehensive analysis of antiviral adaptive immunity formation and reactivation down to single-cell level

• Downloaded 677 times
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  • Site-wide: 36,090
  • In immunology: 1,024
• Year to date:
  • Site-wide: 92,031
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  • Site-wide: 96,024

Genetic determinants of risk and survival in pulmonary arterial hypertension

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  • Site-wide: 36,371
  • In genetics: 1,735
• Year to date:
  • Site-wide: 76,460
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  • Site-wide: 93,185

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

• Downloaded 610 times
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  • Site-wide: 41,209
  • In neurology: 74
• Year to date:
  • Site-wide: 2,105
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  • Site-wide: 530

Immune-related genetic enrichment in frontotemporal dementia

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  • Site-wide: 41,845
  • In genetics: 1,990
• Year to date:
  • Site-wide: 108,049
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  • Site-wide: 116,177

Genome-wide association study of Alzheimer's disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset

• Downloaded 595 times
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  • Site-wide: 42,527
  • In genomics: 3,480
• Year to date:
  • Site-wide: 60,562
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  • Site-wide: 86,882

Common variants in ABCG8 and TRAF3 genes confer risk for gallstone disease and gallbladder cancer in admixed Latinos with Mapuche Native American ancestry

• Downloaded 527 times
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  • Site-wide: 49,279
  • In genetics: 2,309
• Year to date:
  • Site-wide: 71,475
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  • Site-wide: 65,138

Hemibiotrophic fungal pathogen induces systemic susceptibility and systemic shifts in wheat metabolome and microbiome composition

• Downloaded 484 times
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  • Site-wide: 54,530
  • In plant biology: 1,331
• Year to date:
  • Site-wide: 63,412
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  • Site-wide: 46,712

GWAS of stool frequency reveals genes, pathways, and cell types relevant to human gastrointestinal motility and irritable bowel syndrome

• Downloaded 476 times
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  • Site-wide: 55,473
  • In gastroenterology: 49
• Year to date:
  • Site-wide: 29,625
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  • Site-wide: 20,066

Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality

• Downloaded 411 times
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  • Site-wide: 64,708
  • In genetic and genomic medicine: 207
• Year to date:
  • Site-wide: 3,588
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  • Site-wide: 925

Depletion of erythropoietic miR-486-5p and miR-451a improves detectability of rare microRNAs in peripheral blood-derived small RNA sequencing libraries

• Downloaded 351 times
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  • Site-wide: 74,796
  • In molecular biology: 2,201
• Year to date:
  • Site-wide: 77,509
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  • Site-wide: 111,677

Genetic risk for Alzheimer`s disease predicts hippocampal volume through the lifespan

• Downloaded 322 times
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  • Site-wide: 80,316
  • In neuroscience: 12,314
• Year to date:
  • Site-wide: 110,182
• Since beginning of last month:
  • Site-wide: 117,520

Genome-wide analysis of 944,133 individuals provides insights into the etiology of hemorrhoidal disease

• Downloaded 308 times
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  • Site-wide: 83,157
  • In genetic and genomic medicine: 297
• Year to date:
  • Site-wide: 17,761
• Since beginning of last month:
  • Site-wide: 11,662

Primate phageomes are structured by superhost phylogeny and environment

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  • Site-wide: 84,124
  • In microbiology: 5,896
• Year to date:
  • Site-wide: 48,354
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  • Site-wide: 62,205

Identifying Crohns disease signal from variome analysis

• Downloaded 288 times
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  • Site-wide: 87,250
  • In bioinformatics: 7,779
• Year to date:
  • Site-wide: 128,868
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  • Site-wide: 115,663

TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels

• Downloaded 249 times
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  • Site-wide: 95,810
  • In genomics: 5,843
• Year to date:
  • Site-wide: 43,512
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  • Site-wide: 41,940

Occasional paternal inheritance of the germline-restricted chromosome in songbirds

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  • Site-wide: 101,647
  • In genomics: 6,038
• Year to date:
  • Site-wide: 8,831
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  • Site-wide: 21,395

Trans-ethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals shared but also ethnicity-specific disease associations

• Downloaded 210 times
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  • Site-wide: 104,536
  • In genetic and genomic medicine: 436
• Year to date:
  • Site-wide: 44,571
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  • Site-wide: 69,504

Artificial intelligence enables comprehensive genome interpretation and nomination of candidate diagnoses for rare genetic diseases

• Downloaded 184 times
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  • Site-wide: 110,000
  • In genetic and genomic medicine: 480
• Year to date:
  • Site-wide: 11,387
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  • Site-wide: 6,137

Genome-wide association study identifies two new loci associated with anti-NMDAR encephalitis

• Downloaded 92 times
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  • Site-wide: 127,971
  • In neurology: 582
• Year to date:
  • Site-wide: 26,793
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  • Site-wide: 7,463