Author: John Danesh

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Preprints

Analysis of protein-coding genetic variation in 60,706 humans

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  • Site-wide: 289
  • In genomics: 11
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  • Site-wide: 41,708
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  • Site-wide: 41,708

Consequences Of Natural Perturbations In The Human Plasma Proteome

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  • Site-wide: 2,319
  • In genomics: 264
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  • Site-wide: 81,264
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  • Site-wide: 81,264

Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and primary prevention

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  • Site-wide: 2,451
  • In genetics: 98
• Year to date:
  • Site-wide: 33,788
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  • Site-wide: 33,788

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

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  • Site-wide: 2,841
  • In genetics: 115
• Year to date:
  • Site-wide: 11,676
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  • Site-wide: 11,676

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 3,715
  • In genetics: 164
• Year to date:
  • Site-wide: 33,644
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  • Site-wide: 33,644

Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomes

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  • Site-wide: 5,267
  • In genetics: 249
• Year to date:
  • Site-wide: 4,402
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  • Site-wide: 4,402

A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease

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  • Site-wide: 5,451
  • In genomics: 636
• Year to date:
  • Site-wide: 33,904
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  • Site-wide: 33,904

Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

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  • Site-wide: 5,921
  • In genetics: 286
• Year to date:
  • Site-wide: 5,000
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  • Site-wide: 5,000

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

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  • Site-wide: 6,085
  • In genetics: 299
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  • Site-wide: 6,201
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  • Site-wide: 6,201

The Polygenic and Monogenic Basis of Blood Traits and Diseases

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  • Site-wide: 7,158
  • In genetic and genomic medicine: 20
• Year to date:
  • Site-wide: 19,819
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  • Site-wide: 19,819

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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  • Site-wide: 7,888
  • In genetics: 385
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  • Site-wide: None
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ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study

• Downloaded 1,641 times
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  • Site-wide: 9,312
  • In genetic and genomic medicine: 28
• Year to date:
  • Site-wide: 34,419
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  • Site-wide: 34,419

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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  • Site-wide: 9,385
  • In genetics: 465
• Year to date:
  • Site-wide: 81,710
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  • Site-wide: 81,710

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

• Downloaded 1,571 times
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  • Site-wide: 9,933
  • In genomics: 1,105
• Year to date:
  • Site-wide: 47,175
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  • Site-wide: 47,175

Discovery of 318 novel loci for type-2 diabetes and related micro- and macrovascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis.

• Downloaded 1,532 times
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  • Site-wide: 10,293
  • In genetic and genomic medicine: 33
• Year to date:
  • Site-wide: 23,668
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  • Site-wide: 23,668

Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases

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  • Site-wide: 10,406
  • In genetics: 518
• Year to date:
  • Site-wide: 12,397
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  • Site-wide: 12,397

Learning polygenic scores for human blood cell traits

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  • Site-wide: 11,715
  • In genetics: 589
• Year to date:
  • Site-wide: 27,583
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  • Site-wide: 27,583

The Polygenic Score Catalog: an open database for reproducibility and systematic evaluation

• Downloaded 1,212 times
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  • Site-wide: 14,615
  • In genetic and genomic medicine: 47
• Year to date:
  • Site-wide: 4,703
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  • Site-wide: 4,703

Causal Analyses, Statistical Efficiency And Phenotypic Precision Through Recall-By-Genotype Study Design

• Downloaded 1,116 times
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  • Site-wide: 16,580
  • In genetics: 840
• Year to date:
  • Site-wide: 31,173
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  • Site-wide: 31,173

Use of polygenic risk scores and other molecular markers to enhance cardiovascular risk prediction: Prospective cohort study and modelling analysis

• Downloaded 1,056 times
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  • Site-wide: 17,954
  • In genomics: 1,863
• Year to date:
  • Site-wide: 35,712
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  • Site-wide: 35,712

Genetic effects on promoter usage are highly context-specific and contribute to complex traits

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  • Site-wide: 19,039
  • In genomics: 1,958
• Year to date:
  • Site-wide: 37,295
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  • Site-wide: 37,295

Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders

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  • Site-wide: 19,084
  • In genomics: 1,963
• Year to date:
  • Site-wide: 65,736
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  • Site-wide: 65,736

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 794 times
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  • Site-wide: 27,006
  • In genetics: 1,347
• Year to date:
  • Site-wide: 24,303
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  • Site-wide: 24,303

Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

• Downloaded 779 times
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  • Site-wide: 27,752
  • In genomics: 2,601
• Year to date:
  • Site-wide: 98,884
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  • Site-wide: 98,884

Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits

• Downloaded 752 times
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  • Site-wide: 29,160
  • In genetics: 1,453
• Year to date:
  • Site-wide: 112,023
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  • Site-wide: 112,023

Genetic Analyses of Blood Cell Structure for Biological and Pharmacological Inference

• Downloaded 713 times
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  • Site-wide: 31,415
  • In genetics: 1,564
• Year to date:
  • Site-wide: 17,682
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  • Site-wide: 17,682

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

• Downloaded 646 times
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  • Site-wide: 35,889
  • In epidemiology: 1,714
• Year to date:
  • Site-wide: 107,027
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  • Site-wide: 107,027

South Asian Patient Population Genetics Reveal Strong Founder Effects and High Rates of Homozygosity – New Resources for Precision Medicine

• Downloaded 644 times
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  • Site-wide: 36,030
  • In genomics: 3,121
• Year to date:
  • Site-wide: 18,486
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  • Site-wide: 18,486

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

• Downloaded 504 times
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  • Site-wide: 48,795
  • In genetics: 2,341
• Year to date:
  • Site-wide: 3,179
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  • Site-wide: 3,179

Elucidating mechanisms of genetic cross-disease associations: an integrative approach implicates protein C as a causal pathway in arterial and venous diseases

• Downloaded 467 times
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  • Site-wide: 53,230
  • In genetic and genomic medicine: 156
• Year to date:
  • Site-wide: 34,665
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  • Site-wide: 34,665

Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease

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  • Site-wide: 62,426
  • In genetics: 2,960
• Year to date:
  • Site-wide: 72,624
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  • Site-wide: 72,624

Interleukin-6 Receptor Signalling and Abdominal Aortic Aneurysm Growth Rates

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  • Site-wide: 65,557
  • In genetics: 3,085
• Year to date:
  • Site-wide: 100,275
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  • Site-wide: 100,275

Genome-wide analysis of blood lipid metabolites in over 5,000 South Asians reveals biological insights at cardiometabolic disease loci

• Downloaded 361 times
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  • Site-wide: 68,752
  • In genetic and genomic medicine: 205
• Year to date:
  • Site-wide: 23,582
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  • Site-wide: 23,582

Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

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  • Site-wide: 69,537
  • In genetics: 3,255
• Year to date:
  • Site-wide: 101,058
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  • Site-wide: 101,058

Actionable druggable genome-wide Mendelian randomization identifies repurposingopportunities for COVID-19

• Downloaded 326 times
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  • Site-wide: 74,918
  • In epidemiology: 3,091
• Year to date:
  • Site-wide: 13,449
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  • Site-wide: 13,449

The influence of rare variants in circulating metabolic biomarkers

• Downloaded 312 times
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  • Site-wide: 77,500
  • In genetics: 3,597
• Year to date:
  • Site-wide: 113,251
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  • Site-wide: 113,251

Accuracy of four lateral flow immunoassays for anti SARS-CoV-2 antibodies: a head-to-head comparative study

• Downloaded 283 times
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  • Site-wide: 83,317
  • In epidemiology: 3,403
• Year to date:
  • Site-wide: 2,360
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  • Site-wide: 2,360

The 4C Initiative (Clinical Care for Cardiovascular disease in the COVID-19 pandemic): monitoring the indirect impact of the coronavirus pandemic on services for cardiovascular diseases in the UK

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  • Site-wide: 87,627
  • In public and global health: 912
• Year to date:
  • Site-wide: 65,300
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  • Site-wide: 65,300

Comparison of four methods to measure haemoglobin concentrations in whole blood donors (COMPARE): a diagnostic accuracy study

• Downloaded 256 times
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  • Site-wide: 89,066
  • In hematology: 55
• Year to date:
  • Site-wide: 10,882
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  • Site-wide: 10,882

Effects of adiposity on the human plasma proteome: Observational and Mendelian randomization estimates

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  • Site-wide: 98,302
  • In epidemiology: 3,989
• Year to date:
  • Site-wide: 22,819
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  • Site-wide: 22,819