Author: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

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Preprints

Analysis of shared heritability in common disorders of the brain

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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Genetic Identification Of Brain Cell Types Underlying Schizophrenia

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Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

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The genetics of the mood disorder spectrum: genome-wide association analyses of over 185,000 cases and 439,000 controls

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Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

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Testing Causal Bidirectional Influences between Physical Activity and Depression using Mendelian Randomization

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Using genotype data to distinguish pleiotropy from heterogeneity: deciphering coheritability in autoimmune and neuropsychiatric diseases

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Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder

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Cannabis use, depression and self-harm: phenotypic and genetic relationships

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Polygenic scores for major depressive disorder and depressive symptoms predict response to lithium in patients with bipolar disorder

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A comprehensive evaluation of polygenic score methods across cohorts in psychiatric disorders

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Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

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Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

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A two-stage approach to identifying and validating modifiable factors for the prevention of depression

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Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

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Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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A validation of the diathesis-stress model for depression in Generation Scotland.

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Accelerated Epigenetic Ageing in Major Depressive Disorder

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Variably methylated regions in the newborn epigenome: environmental, genetic and combined influences

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Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

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A Gene Co-expression Network-based Analysis of Multiple Brain Tissues Reveals Novel Genes and Molecular Pathways Underlying Major Depression

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Genetic comorbidity between major depression and cardio-metabolic disease, stratified by age at onset of major depression.

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Does Neuroticism Cause Depression? A Mendelian Randomization Study

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Genetic variation in the Major Histocompatibility Complex and association with depression

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Genome-wide by environment interaction studies (GWEIS) of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland.

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Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

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  • Site-wide: 74,090
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  • Site-wide: 110,616

Response to Therapeutic Sleep Deprivation: A Naturalistic Study of Clinical and Genetic Factors and Post-Treatment Depressive Symptom Trajectory

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  • In epidemiology: 2,843
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Genetic susceptibility for major depressive disorder associates with trajectories of depressive symptoms across childhood and adolescence

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  • Site-wide: 46,985