Author: Alex K. Shalek

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Preprints

Systematic comparative analysis of single cell RNA-sequencing methods

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  • Site-wide: 471
  • In genomics: 29
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  • Site-wide: 1,430
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  • Site-wide: 1,430

Highly Efficient, Massively-Parallel Single-Cell RNA-Seq Reveals Cellular States and Molecular Features of Human Skin Pathology

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  • Site-wide: 1,963
  • In immunology: 50
• Year to date:
  • Site-wide: 4,356
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  • Site-wide: 4,356

Rewiring of the cellular and inter-cellular landscape of the human colon during ulcerative colitis

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  • Site-wide: 2,342
  • In genomics: 266
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Sensory Neurons Innervate Peripheral Lymph Nodes and Locally Regulate Gene Expression in Postsynaptic Endothelium, Stromal Cells, and Innate Leukocytes

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  • Site-wide: 2,478
  • In immunology: 68
• Year to date:
  • Site-wide: 4,634
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T helper cells modulate intestinal stem cell renewal and differentiation

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  • Site-wide: 5,882
  • In immunology: 163
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Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases

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  • Site-wide: 6,339
  • In genetic and genomic medicine: 18
• Year to date:
  • Site-wide: 1,849
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  • Site-wide: 1,849

High-throughput organoid screening enables engineering of intestinal epithelial composition

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  • Site-wide: 7,239
  • In bioengineering: 116
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  • Site-wide: 9,577
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Transcriptional subtype-specific microenvironmental crosstalk and tumor cell plasticity in metastatic pancreatic cancer

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  • Site-wide: 8,548
  • In cancer biology: 157
• Year to date:
  • Site-wide: 3,125
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  • Site-wide: 3,125

Single-cell analysis of upper airway cells reveals host-viral dynamics in influenza infected adults

• Downloaded 1,684 times
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  • Site-wide: 9,043
  • In genomics: 1,019
• Year to date:
  • Site-wide: 4,092
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  • Site-wide: 4,092

Alterations of multiple alveolar macrophage states in chronic obstructive pulmonary disease

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  • Site-wide: 11,388
  • In systems biology: 223
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  • Site-wide: 10,691
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  • Site-wide: 10,691

Reduced cellular diversity and an altered basal progenitor cell state inform epithelial barrier dysfunction in human type 2 immunity

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  • Site-wide: 11,629
  • In immunology: 317
• Year to date:
  • Site-wide: 60,442
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  • Site-wide: 60,442

Identification of a master regulator of differentiation in Toxoplasma

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  • Site-wide: 12,018
  • In microbiology: 670
• Year to date:
  • Site-wide: 53,910
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  • Site-wide: 53,910

Integrated Single-Cell Analysis of Multicellular Immune Dynamics during Hyper-Acute HIV-1 Infection

• Downloaded 1,168 times
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  • Site-wide: 15,546
  • In immunology: 430
• Year to date:
  • Site-wide: 47,430
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  • Site-wide: 47,430

Single-cell profiling of Ebola virus infection in vivo reveals viral and host transcriptional dynamics

• Downloaded 1,125 times
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  • Site-wide: 16,470
  • In microbiology: 917
• Year to date:
  • Site-wide: 31,278
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  • Site-wide: 31,278

Single cell profiling of COVID-19 patients: an international data resource from multiple tissues

• Downloaded 1,079 times
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  • Site-wide: 17,547
  • In infectious diseases: 1,499
• Year to date:
  • Site-wide: 1,752
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  • Site-wide: 1,752

Spatially-Resolved Live Cell Tagging and Isolation Using Protected Photoactivatable Cell Dyes

• Downloaded 1,031 times
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  • Site-wide: 18,798
  • In systems biology: 388
• Year to date:
  • Site-wide: 29,993
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  • Site-wide: 29,993

Linking single-cell measurements of mass, growth rate, and gene expression

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  • Site-wide: 19,024
  • In bioengineering: 321
• Year to date:
  • Site-wide: 116,287
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  • Site-wide: 116,287

Single-cell profiling of tuberculosis lung granulomas reveals functional lymphocyte signatures of bacterial control

• Downloaded 923 times
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  • Site-wide: 22,001
  • In immunology: 621
• Year to date:
  • Site-wide: 6,490
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  • Site-wide: 6,490

Single-cell analysis reveals mechanisms of plasticity of leukemia initiating cells

• Downloaded 575 times
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  • Site-wide: 41,781
  • In cancer biology: 1,158
• Year to date:
  • Site-wide: 36,387
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  • Site-wide: 36,387

IL-5Rα marks nasal polyp IgG4 and IgE-secreting cells in aspirin-exacerbated respiratory disease

• Downloaded 531 times
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  • Site-wide: 46,208
  • In immunology: 1,244
• Year to date:
  • Site-wide: 95,833
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  • Site-wide: 95,833

Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states

• Downloaded 519 times
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  • Site-wide: 47,381
  • In cancer biology: 1,324
• Year to date:
  • Site-wide: 6,059
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  • Site-wide: 6,059

Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells

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  • Site-wide: 51,116
  • In immunology: 1,391
• Year to date:
  • Site-wide: 26,773
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  • Site-wide: 26,773

Single Cell and Spatial Transcriptomics Defines the Cellular Architecture of the Antimicrobial Response Network in Human Leprosy Granulomas

• Downloaded 465 times
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  • Site-wide: 53,838
  • In immunology: 1,455
• Year to date:
  • Site-wide: 12,085
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  • Site-wide: 12,085

GM-CSF differentiation of human monocytes stabilizes macrophage state via oxidative signaling

• Downloaded 377 times
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  • Site-wide: 66,492
  • In immunology: 1,788
• Year to date:
  • Site-wide: 22,384
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  • Site-wide: 22,384

Spatiotemporal single-cell profiling of gastrointestinal GVHD reveals invasive and resident memory T cell states.

• Downloaded 344 times
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  • Site-wide: 72,029
  • In immunology: 1,952
• Year to date:
  • Site-wide: 16,094
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  • Site-wide: 16,094

Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu

• Downloaded 242 times
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  • Site-wide: 92,466
  • In immunology: 2,556
• Year to date:
  • Site-wide: 22,388
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  • Site-wide: 22,388

MR1-restricted MAIT cells from the human lung mucosal surface have distinct phenotypic, functional, and transcriptomic features that are preserved in HIV infection

• Downloaded 124 times
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  • Site-wide: 116,629
  • In immunology: 3,277
• Year to date:
  • Site-wide: 30,669
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  • Site-wide: 30,669

Measuring kinetics and metastatic propensity of CTCs by blood exchange between mice

• Downloaded 106 times
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  • Site-wide: 119,855
  • In cancer biology: 3,761
• Year to date:
  • Site-wide: 59,478
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  • Site-wide: 59,478