Author: Michael P. Snyder

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Preprints

Index Switching Causes “Spreading-Of-Signal” Among Multiplexed Samples In Illumina HiSeq 4000 DNA Sequencing

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  • Site-wide: 250
  • In molecular biology: 3
• Year to date:
  • Site-wide: 6,661
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  • Site-wide: 7,723

A Quantitative Proteome Map of the Human Body

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  • Site-wide: 2,938
  • In systems biology: 40
• Year to date:
  • Site-wide: 15,826
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  • Site-wide: 7,898

Molecular Choreography of Acute Exercise

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  • Site-wide: 4,547
  • In systems biology: 78
• Year to date:
  • Site-wide: 6,825
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  • Site-wide: 5,266

A genome-wide almanac of co-essential modules assigns function to uncharacterized genes

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  • Site-wide: 5,306
  • In genomics: 638
• Year to date:
  • Site-wide: 10,227
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  • Site-wide: 14,099

Identification and mitigation of pervasive off-target activity in CRISPR-Cas9 screens for essential non-coding elements

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  • Site-wide: 6,299
  • In genomics: 742
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  • Site-wide: None
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  • Site-wide: 109,075

Old fibroblasts secrete inflammatory cytokines that drive variability in reprogramming efficiency and may affect wound healing between old individuals

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  • Site-wide: 7,305
  • In cell biology: 173
• Year to date:
  • Site-wide: 22,797
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  • Site-wide: 28,594

High Frequency Actionable Pathogenic Exome Mutations in an Average-Risk Cohort

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  • Site-wide: 7,677
  • In genomics: 878
• Year to date:
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  • Site-wide: 61,701

Static And Dynamic DNA Loops Form AP-1 Bound Activation Hubs During Macrophage Development

• Downloaded 1,638 times
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  • Site-wide: 8,781
  • In genomics: 1,015
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  • Site-wide: None
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  • Site-wide: 120,352

Integrative analysis of RNA, translation and protein levels reveals distinct regulatory variation across humans

• Downloaded 1,416 times
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  • Site-wide: 10,909
  • In genomics: 1,242
• Year to date:
  • Site-wide: 85,570
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  • Site-wide: 71,600

Cross-species blastocyst chimerism between nonhuman primates using iPSCs

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  • Site-wide: 15,392
  • In developmental biology: 257
• Year to date:
  • Site-wide: 26,987
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  • Site-wide: 46,494

The dynamic, combinatorial cis-regulatory lexicon of epidermal differentiation

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  • Site-wide: 17,994
  • In genomics: 1,900
• Year to date:
  • Site-wide: 2,959
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  • Site-wide: 4,280

A limited set of transcriptional programs define major cell types

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  • Site-wide: 20,948
  • In genomics: 2,130
• Year to date:
  • Site-wide: 29,970
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  • Site-wide: 97,138

Genome-wide Identification of the Genetic Basis of Amyotrophic Lateral Sclerosis

• Downloaded 694 times
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  • Site-wide: 30,888
  • In genomics: 2,814
• Year to date:
  • Site-wide: 32,758
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  • Site-wide: 3,342

NF90/ILF3 is a transcription factor that promotes proliferation over differentiation by hierarchical regulation in K562 erythroleukemia cells

• Downloaded 682 times
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  • Site-wide: 31,630
  • In genetics: 1,595
• Year to date:
  • Site-wide: 38,574
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  • Site-wide: 61,865

Chromosome-level de novo assembly of the pig-tailed macaque genome using linked-read sequencing and HiC proximity scaffolding

• Downloaded 643 times
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  • Site-wide: 34,186
  • In genomics: 3,034
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  • Site-wide: 88,305
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  • Site-wide: 113,713

A Common Class of Transcripts with 5'-Intron Depletion, Distinct Early Coding Sequence Features, and N1-Methyladenosine Modification

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  • Site-wide: 37,360
  • In bioinformatics: 4,189
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  • Site-wide: None
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  • Site-wide: 119,730

Benchmarking workflows to assess performance and suitability of germline variant calling pipelines in clinical diagnostic assays.

• Downloaded 496 times
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  • Site-wide: 47,094
  • In bioinformatics: 5,001
• Year to date:
  • Site-wide: 20,677
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  • Site-wide: 40,485

KLF4 Recruits SWI/SNF to Increase Chromatin Accessibility and Reprogram the Endothelial Enhancer Landscape under Laminar Shear Stress

• Downloaded 375 times
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  • Site-wide: 63,277
  • In molecular biology: 1,864
• Year to date:
  • Site-wide: 13,862
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  • Site-wide: 21,594

Tyrosine kinase inhibitors induce mitochondrial dysfunction during cardiomyocyte differentiation through alteration of GATA4-mediated networks

• Downloaded 349 times
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  • Site-wide: 67,580
  • In systems biology: 1,674
• Year to date:
  • Site-wide: 32,385
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  • Site-wide: 26,526

RobNorm: model-based robust normalization methodfor labeled quantitative mass spectrometry proteomics data

• Downloaded 347 times
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  • Site-wide: 67,783
  • In bioinformatics: 6,585
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  • Site-wide: 51,787
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  • Site-wide: 12,204

HAT1 drives a gene-metabolite circuit that links nutrient metabolism to histone production

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  • Site-wide: 75,729
  • In molecular biology: 2,242
• Year to date:
  • Site-wide: 75,385
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  • Site-wide: 77,745

Age-related decline in metabolite heavy isotope content in rodent organs

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  • Site-wide: 93,450
  • In systems biology: 2,233
• Year to date:
  • Site-wide: 27,984
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  • Site-wide: 63,396

AdaTiSS: A Novel Data-Adaptive Robust Method for Quantifying Tissue Specificity Scores

• Downloaded 207 times
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  • Site-wide: 95,225
  • In bioinformatics: 8,337
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  • Site-wide: None
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  • Site-wide: 99,980

AdaReg: Data Adaptive Robust Estimation in Linear Regression with Application in GTEx Gene Expressions

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  • Site-wide: 96,911
  • In bioinformatics: 8,417
• Year to date:
  • Site-wide: 49,879
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  • Site-wide: 61,287

Physical exercise is a risk factor for amyotrophic lateral sclerosis: Convergent evidence from mendelian randomisation, transcriptomics and risk genotypes

• Downloaded 103 times
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  • Site-wide: 115,147
  • In neurology: 447
• Year to date:
  • Site-wide: 26,507
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  • Site-wide: 5,766

Deep learning-based detection of COVID-19 using wearables data

• Downloaded 95 times
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  • Site-wide: 116,513
  • In infectious diseases: 3,725
• Year to date:
  • Site-wide: 1,552
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  • Site-wide: None