Author: Sarah E. Harris

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Preprints

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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  • Site-wide: 3,475
  • In genetics: 148
• Year to date:
  • Site-wide: 26,075
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  • Site-wide: 28,266

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 3,748
  • In genetics: 166
• Year to date:
  • Site-wide: 35,226
• Since beginning of last month:
  • Site-wide: 37,020

Molecular genetic contributions to self-rated health

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  • Site-wide: 6,032
  • In genetics: 291
• Year to date:
  • Site-wide: 54,680
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  • Site-wide: 50,778

GWAS on family history of Alzheimer's disease

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  • Site-wide: 7,104
  • In genetics: 345
• Year to date:
  • Site-wide: 60,876
• Since beginning of last month:
  • Site-wide: 33,001

Genetic Prediction of Male Pattern Baldness

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  • Site-wide: 8,285
  • In genetics: 403
• Year to date:
  • Site-wide: 41,904
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  • Site-wide: 35,489

Molecular genetic contributions to social deprivation and household income in UK Biobank (n = 112,151)

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  • Site-wide: 9,659
  • In genetics: 482
• Year to date:
  • Site-wide: 62,258
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  • Site-wide: 49,578

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

• Downloaded 1,571 times
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  • Site-wide: 10,046
  • In genomics: 1,111
• Year to date:
  • Site-wide: 55,611
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  • Site-wide: 48,676

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

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  • Site-wide: 12,594
  • In genetics: 633
• Year to date:
  • Site-wide: 80,417
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  • Site-wide: 42,589

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

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  • Site-wide: 13,472
  • In bioinformatics: 1,666
• Year to date:
  • Site-wide: 57,814
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  • Site-wide: 81,223

Identification of 55,000 Replicated DNA Methylation QTL

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  • Site-wide: 18,655
  • In genomics: 1,922
• Year to date:
  • Site-wide: 71,511
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  • Site-wide: 63,235

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

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  • Site-wide: 19,027
  • In genetics: 947
• Year to date:
  • Site-wide: 6,692
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  • Site-wide: 7,094

Genome wide analysis of gene dosage in 24,092 individuals shows that 10,000 genes modulate cognitive ability

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  • Site-wide: 19,450
  • In genetics: 969
• Year to date:
  • Site-wide: 8,883
• Since beginning of last month:
  • Site-wide: 13,948

An epigenome-wide association study of educational attainment (n = 10,767)

• Downloaded 984 times
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  • Site-wide: 20,167
  • In genetics: 999
• Year to date:
  • Site-wide: 48,417
• Since beginning of last month:
  • Site-wide: 42,540

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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  • Site-wide: 29,803
  • In genomics: 2,727
• Year to date:
  • Site-wide: 70,224
• Since beginning of last month:
  • Site-wide: 63,333

Genetic contributions to self-reported tiredness

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  • Site-wide: 31,857
  • In genetics: 1,581
• Year to date:
  • Site-wide: 31,824
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  • Site-wide: 44,494

Cognitive ability and physical health: a Mendelian randomization study

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  • Site-wide: 39,425
  • In genetics: 1,914
• Year to date:
  • Site-wide: 91,765
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  • Site-wide: 93,947

Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank

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  • Site-wide: 42,970
  • In genetics: 2,068
• Year to date:
  • Site-wide: 85,257
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  • Site-wide: 97,243

Three major dimensions of human brain cortical ageing in relation to cognitive decline across the 8th decade of life.

• Downloaded 557 times
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  • Site-wide: 43,779
  • In neuroscience: 6,385
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  • Site-wide: 38,813
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  • Site-wide: 28,732

Linked mutations at adjacent nucleotides have shaped human population differentiation and protein evolution

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  • Site-wide: 48,729
  • In genomics: 3,877
• Year to date:
  • Site-wide: 118,672
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  • Site-wide: None

Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions

• Downloaded 484 times
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  • Site-wide: 51,627
  • In genomics: 4,048
• Year to date:
  • Site-wide: 89,158
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  • Site-wide: 80,368

Polygenic predictors of age-related decline in cognitive ability

• Downloaded 479 times
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  • Site-wide: 52,264
  • In genomics: 4,076
• Year to date:
  • Site-wide: 113,288
• Since beginning of last month:
  • Site-wide: 93,512

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 475 times
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  • Site-wide: 52,793
  • In genetics: 2,509
• Year to date:
  • Site-wide: 85,991
• Since beginning of last month:
  • Site-wide: 73,630

Genetic contributions to trail making test performance in UK Biobank

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  • Site-wide: 55,114
  • In genetics: 2,615
• Year to date:
  • Site-wide: 108,347
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  • Site-wide: 79,670

Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults

• Downloaded 449 times
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  • Site-wide: 56,028
  • In genomics: 4,263
• Year to date:
  • Site-wide: 88,366
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  • Site-wide: 82,243

Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

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  • Site-wide: 65,857
  • In neuroscience: 10,055
• Year to date:
  • Site-wide: 112,145
• Since beginning of last month:
  • Site-wide: 87,084

An epigenetic predictor of death captures multi-modal measures of brain health

• Downloaded 365 times
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  • Site-wide: 68,822
  • In neuroscience: 10,539
• Year to date:
  • Site-wide: 118,211
• Since beginning of last month:
  • Site-wide: 87,223

Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function

• Downloaded 341 times
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  • Site-wide: 72,878
  • In genetics: 3,387
• Year to date:
  • Site-wide: 113,706
• Since beginning of last month:
  • Site-wide: 88,833

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

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  • Site-wide: 83,412
  • In epidemiology: 3,414
• Year to date:
  • Site-wide: 101,252
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  • Site-wide: 52,101

Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

• Downloaded 269 times
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  • Site-wide: 87,047
  • In cell biology: 4,056
• Year to date:
  • Site-wide: 72,451
• Since beginning of last month:
  • Site-wide: 54,986

An epigenetic proxy of chronic inflammation outperforms serum levels as a biomarker of brain ageing

• Downloaded 265 times
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  • Site-wide: 88,016
  • In neurology: 220
• Year to date:
  • Site-wide: 19,640
• Since beginning of last month:
  • Site-wide: 18,975

Neurology-related protein biomarkers are associated with general fluid cognitive ability and brain volume in older age

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  • Site-wide: 96,867
  • In neuroscience: 15,186
• Year to date:
  • Site-wide: 116,594
• Since beginning of last month:
  • Site-wide: 97,458

Creating and validating a DNA methylation-based proxy for Interleukin-6

• Downloaded 218 times
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  • Site-wide: 97,973
  • In genetic and genomic medicine: 367
• Year to date:
  • Site-wide: 46,729
• Since beginning of last month:
  • Site-wide: 86,102

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 199 times
• Download rankings, all-time:
  • Site-wide: 102,155
  • In genomics: 6,027
• Year to date:
  • Site-wide: 102,847
• Since beginning of last month:
  • Site-wide: 101,181

DNA methylation proxies for 16 plasma proteins predict the incidence of 7 leading causes of morbidity

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  • Site-wide: 103,612
  • In genomics: 6,073
• Year to date:
  • Site-wide: 17,320
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  • Site-wide: 24,897

Pulmonary function and risk of Alzheimer dementia: two-sample Mendelian randomization study

• Downloaded 177 times
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  • Site-wide: 106,878
  • In epidemiology: 4,361
• Year to date:
  • Site-wide: 66,643
• Since beginning of last month:
  • Site-wide: 47,641

Plasma lipid and liporotein biomarkers in LBC1936: Do they predict general cognitive ability and brain structure?

• Downloaded 112 times
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  • Site-wide: 119,186
  • In neuroscience: 18,485
• Year to date:
  • Site-wide: 101,894
• Since beginning of last month:
  • Site-wide: 101,235

Epigenetic predictors of lifestyle traits applied to the blood and brain

• Downloaded 107 times
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  • Site-wide: 120,204
  • In genetic and genomic medicine: 550
• Year to date:
  • Site-wide: 68,895
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  • Site-wide: 82,602

A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens

• Downloaded 105 times
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  • Site-wide: 120,553
  • In neuroscience: 18,675
• Year to date:
  • Site-wide: None
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