Author: Erik Ingelsson

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Preprints

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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  • Site-wide: 3,325
  • In genomics: 392
• Year to date:
  • Site-wide: 64,444
• Since beginning of last month:
  • Site-wide: 93,113

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 3,581
  • In genetics: 164
• Year to date:
  • Site-wide: 27,626
• Since beginning of last month:
  • Site-wide: 42,014

Large-scale non-targeted metabolomic profiling in three human population-based studies

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  • Site-wide: 3,711
  • In bioinformatics: 405
• Year to date:
  • Site-wide: 37,046
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  • Site-wide: 46,101

Identification of rare-disease genes in diverse undiagnosed cases using whole blood transcriptome sequencing and large control cohorts

• Downloaded 2,239 times
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  • Site-wide: 5,636
  • In genomics: 673
• Year to date:
  • Site-wide: 29,088
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  • Site-wide: 41,742

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

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  • Site-wide: 6,235
  • In genetics: 311
• Year to date:
  • Site-wide: 8,218
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  • Site-wide: 7,503

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,842 times
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  • Site-wide: 7,461
  • In genetics: 370
• Year to date:
  • Site-wide: 27,085
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  • Site-wide: 101,435

Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight novel adipocyte biology

• Downloaded 1,669 times
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  • Site-wide: 8,689
  • In genetics: 440
• Year to date:
  • Site-wide: 28,393
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  • Site-wide: 31,830

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,627 times
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  • Site-wide: 9,030
  • In genetics: 459
• Year to date:
  • Site-wide: 81,743
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  • Site-wide: 38,633

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

• Downloaded 1,455 times
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  • Site-wide: 10,623
  • In genetics: 540
• Year to date:
  • Site-wide: 48,422
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  • Site-wide: 68,166

Genetic analyses in UK Biobank identifies 78 novel loci associated with urinary biomarkers providing new insights into the biology of kidney function and chronic disease

• Downloaded 1,451 times
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  • Site-wide: 10,684
  • In genetics: 545
• Year to date:
  • Site-wide: 76,586
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  • Site-wide: 34,923

Large-scale phenome-wide association study of PCSK9 loss-of-function variants demonstrates protection against ischemic stroke

• Downloaded 1,101 times
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  • Site-wide: 16,214
  • In genetics: 838
• Year to date:
  • Site-wide: 62,955
• Since beginning of last month:
  • Site-wide: 55,420

Zebrafish larvae as a model system for systematic characterization of drugs and genes in dyslipidemia and atherosclerosis

• Downloaded 1,039 times
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  • Site-wide: 17,658
  • In genomics: 1,852
• Year to date:
  • Site-wide: 54,529
• Since beginning of last month:
  • Site-wide: 24,880

Fitness, Physical Activity, And Cardiovascular Disease: Longitudinal And Genetic Analyses In The UK Biobank Study

• Downloaded 960 times
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  • Site-wide: 19,838
  • In epidemiology: 1,118
• Year to date:
  • Site-wide: 52,422
• Since beginning of last month:
  • Site-wide: 82,611

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 914 times
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  • Site-wide: 21,326
  • In genetic and genomic medicine: 61
• Year to date:
  • Site-wide: 3,621
• Since beginning of last month:
  • Site-wide: 5,816

Genetic dysregulation of gene expression and splicing during a ten-year period of human aging

• Downloaded 814 times
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  • Site-wide: 25,134
  • In genomics: 2,410
• Year to date:
  • Site-wide: 95,775
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  • Site-wide: 68,073

Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9/based approach

• Downloaded 802 times
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  • Site-wide: 25,646
  • In genomics: 2,438
• Year to date:
  • Site-wide: 26,984
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  • Site-wide: 38,691

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

• Downloaded 792 times
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  • Site-wide: 26,090
  • In genetics: 1,319
• Year to date:
  • Site-wide: 75,314
• Since beginning of last month:
  • Site-wide: 108,115

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 764 times
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  • Site-wide: 27,421
  • In genetics: 1,385
• Year to date:
  • Site-wide: 28,732
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  • Site-wide: 24,384

Birthweight, Type 2 Diabetes and Cardiovascular Disease: Addressing the Barker Hypothesis with Mendelian randomization

• Downloaded 739 times
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  • Site-wide: 28,756
  • In genetics: 1,441
• Year to date:
  • Site-wide: 54,216
• Since beginning of last month:
  • Site-wide: 102,167

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 738 times
• Download rankings, all-time:
  • Site-wide: 28,782
  • In genomics: 2,663
• Year to date:
  • Site-wide: 50,044
• Since beginning of last month:
  • Site-wide: 109,607

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

• Downloaded 703 times
• Download rankings, all-time:
  • Site-wide: 30,790
  • In genetics: 1,549
• Year to date:
  • Site-wide: 96,437
• Since beginning of last month:
  • Site-wide: 87,581

Biological Insights Into Muscular Strength: Genetic Findings in the UK Biobank

• Downloaded 667 times
• Download rankings, all-time:
  • Site-wide: 33,038
  • In genomics: 2,938
• Year to date:
  • Site-wide: 107,353
• Since beginning of last month:
  • Site-wide: 106,691

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 665 times
• Download rankings, all-time:
  • Site-wide: 33,163
  • In genetics: 1,653
• Year to date:
  • Site-wide: 11,148
• Since beginning of last month:
  • Site-wide: 11,241

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

• Downloaded 652 times
• Download rankings, all-time:
  • Site-wide: 34,068
  • In genetics: 1,698
• Year to date:
  • Site-wide: 121,085
• Since beginning of last month:
  • Site-wide: 90,787

Bioimpedance and new onset heart failure: A longitudinal study of ~500,000 individuals from the general population

• Downloaded 608 times
• Download rankings, all-time:
  • Site-wide: 37,303
  • In epidemiology: 1,737
• Year to date:
  • Site-wide: 121,430
• Since beginning of last month:
  • Site-wide: 120,307

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 587 times
• Download rankings, all-time:
  • Site-wide: 38,987
  • In genetics: 1,917
• Year to date:
  • Site-wide: 93,094
• Since beginning of last month:
  • Site-wide: 65,390

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

• Downloaded 560 times
• Download rankings, all-time:
  • Site-wide: 41,335
  • In genetics: 2,024
• Year to date:
  • Site-wide: 21,812
• Since beginning of last month:
  • Site-wide: 79,588

Genetic regulatory mechanisms of smooth muscle cells map to coronary artery disease risk loci

• Downloaded 508 times
• Download rankings, all-time:
  • Site-wide: 46,506
  • In genomics: 3,755
• Year to date:
  • Site-wide: 111,081
• Since beginning of last month:
  • Site-wide: 109,677

Loss of function, missense, and intronic variants in NOTCH1 confer different risks for left ventricular outflow tract obstructive heart defects in two European cohorts

• Downloaded 501 times
• Download rankings, all-time:
  • Site-wide: 47,252
  • In genetics: 2,284
• Year to date:
  • Site-wide: 59,106
• Since beginning of last month:
  • Site-wide: 80,289

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 468 times
• Download rankings, all-time:
  • Site-wide: 51,157
  • In genetics: 2,470
• Year to date:
  • Site-wide: 68,275
• Since beginning of last month:
  • Site-wide: 114,160

Urinary biomarkers and cardiovascular outcomes in the UK Biobank: observational and Mendelian randomization analyses

• Downloaded 356 times
• Download rankings, all-time:
  • Site-wide: 67,269
  • In epidemiology: 2,761
• Year to date:
  • Site-wide: 118,028
• Since beginning of last month:
  • Site-wide: 108,318

Prediction performance of a cardiovascular risk assessment tool using Stanford EHR data repository

• Downloaded 325 times
• Download rankings, all-time:
  • Site-wide: 72,681
  • In bioinformatics: 6,845
• Year to date:
  • Site-wide: 87,660
• Since beginning of last month:
  • Site-wide: 117,802

Development and validation of a next-gen health stratification engine to determine risk for multiple cardiovascular diseases

• Downloaded 324 times
• Download rankings, all-time:
  • Site-wide: 72,747
  • In bioinformatics: 6,868
• Year to date:
  • Site-wide: 102,202
• Since beginning of last month:
  • Site-wide: 107,987

A phenome-wide association study of four syndromic genes reveals pleiotropic effects of common and rare variants in the general population

• Downloaded 275 times
• Download rankings, all-time:
  • Site-wide: 82,227
  • In genetic and genomic medicine: 259
• Year to date:
  • Site-wide: 39,365
• Since beginning of last month:
  • Site-wide: 97,064

Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study

• Downloaded 272 times
• Download rankings, all-time:
  • Site-wide: 82,936
  • In cardiovascular medicine: 126
• Year to date:
  • Site-wide: 31,423
• Since beginning of last month:
  • Site-wide: 82,521

Clinical conditions and their impact on utility of genetic scores for prediction of acute coronary syndrome

• Downloaded 178 times
• Download rankings, all-time:
  • Site-wide: 102,641
  • In cardiovascular medicine: 200
• Year to date:
  • Site-wide: 58,576
• Since beginning of last month:
  • Site-wide: 69,156

Alcohol use and cardiometabolic risk in the UK Biobank: a Mendelian randomization study

• Downloaded 140 times
• Download rankings, all-time:
  • Site-wide: 110,011
  • In genetics: 4,879
• Year to date:
  • Site-wide: 75,395
• Since beginning of last month:
  • Site-wide: 30,371