Author: Xiaoquan Wen

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Preprints

The GTEx Consortium atlas of genetic regulatory effects across human tissues

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  • Site-wide: 978
  • In genetics: 29
• Year to date:
  • Site-wide: 3,025
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  • Site-wide: 2,543

Local genetic effects on gene expression across 44 human tissues

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  • Site-wide: 2,202
  • In genomics: 249
• Year to date:
  • Site-wide: 45,989
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  • Site-wide: 29,433

Genome-wide association study of 1 million people identifies 111 loci for atrial fibrillation

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  • Site-wide: 3,401
  • In genetics: 139
• Year to date:
  • Site-wide: 43,642
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  • Site-wide: 34,826

Exploiting the GTEx resources to decipher the mechanisms at GWAS loci

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  • Site-wide: 3,459
  • In genetics: 147
• Year to date:
  • Site-wide: 9,601
• Since beginning of last month:
  • Site-wide: None

Cell type specific genetic regulation of gene expression across human tissues

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  • Site-wide: 5,110
  • In genomics: 602
• Year to date:
  • Site-wide: 12,565
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  • Site-wide: 9,248

PhenomeXcan: Mapping the genome to the phenome through the transcriptome

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  • Site-wide: 9,661
  • In genetics: 483
• Year to date:
  • Site-wide: 27,398
• Since beginning of last month:
  • Site-wide: 23,383

Which genetic variants in DNase I sensitive regions are functional?

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  • Site-wide: 10,890
  • In genomics: 1,208
• Year to date:
  • Site-wide: 104,613
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  • Site-wide: None

QuASAR: Quantitative Allele Specific Analysis of Reads

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  • Site-wide: 12,199
  • In bioinformatics: 1,509
• Year to date:
  • Site-wide: 48,669
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  • Site-wide: 76,362

Cross-population Joint Analysis of eQTLs: Fine Mapping and Functional Annotation

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  • Site-wide: 14,403
  • In genetics: 740
• Year to date:
  • Site-wide: 79,887
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  • Site-wide: None

High throughput characterization of genetic effects on DNA:protein binding and gene transcription

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  • Site-wide: 16,100
  • In genetics: 815
• Year to date:
  • Site-wide: 110,098
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  • Site-wide: None

QuASAR-MPRA: Accurate allele-specific analysis for massively parallel reporter assays

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  • Site-wide: 18,804
  • In bioinformatics: 2,273
• Year to date:
  • Site-wide: 103,289
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  • Site-wide: 76,934

Efficient Integrative Multi-SNP Association Analysis using Deterministic Approximation of Posteriors

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  • Site-wide: 19,294
  • In genetics: 962
• Year to date:
  • Site-wide: 41,777
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  • Site-wide: 48,396

Bayesian Multi-SNP Genetic Association Analysis: Control of FDR and Use of Summary Statistics

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  • Site-wide: 19,510
  • In genetics: 973
• Year to date:
  • Site-wide: 20,036
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  • Site-wide: 17,300

Investigating tissue-relevant causal molecular mechanisms of complex traits using probabilistic TWAS analysis

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  • Site-wide: 23,941
  • In genetics: 1,188
• Year to date:
  • Site-wide: 37,549
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  • Site-wide: 47,474

Impact of admixture and ancestry on eQTL analysis and GWAS colocalization in GTEx

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  • Site-wide: 24,499
  • In genetics: 1,211
• Year to date:
  • Site-wide: 34,184
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  • Site-wide: 25,995

Integrating Comprehensive Functional Annotations to Boost Power and Accuracy in Gene-Based Association Analysis

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  • Site-wide: 30,447
  • In genetics: 1,511
• Year to date:
  • Site-wide: 72,801
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  • Site-wide: 92,195

Effective QTL Discovery Incorporating Genomic Annotations

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  • Site-wide: 30,761
  • In genetics: 1,527
• Year to date:
  • Site-wide: 23,028
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  • Site-wide: 13,649

Integrating Molecular QTL Data into Genome-wide Genetic Association Analysis: Probabilistic Assessment of Enrichment and Colocalization

• Downloaded 662 times
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  • Site-wide: 35,007
  • In genetics: 1,713
• Year to date:
  • Site-wide: 48,585
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  • Site-wide: 52,680

Interpreting coronary artery disease risk through gene-environment interactions in gene regulation

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  • Site-wide: 35,808
  • In genomics: 3,111
• Year to date:
  • Site-wide: 53,716
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  • Site-wide: 39,909

Fine-mapping and QTL tissue-sharing information improve causal gene identification and transcriptome prediction performance

• Downloaded 650 times
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  • Site-wide: 35,826
  • In genomics: 3,121
• Year to date:
  • Site-wide: 22,894
• Since beginning of last month:
  • Site-wide: 16,705

Probabilistic Colocalization of Genetic Variants from Complex and Molecular Traits: Promise and Limitations

• Downloaded 431 times
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  • Site-wide: 58,373
  • In genetics: 2,765
• Year to date:
  • Site-wide: 19,216
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  • Site-wide: 21,903

Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions

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  • Site-wide: 60,844
  • In genomics: 4,482
• Year to date:
  • Site-wide: 1,599
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  • Site-wide: 485

Interspecies variation in hominid gut microbiota controls host gene regulation

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  • Site-wide: 61,485
  • In genomics: 4,509
• Year to date:
  • Site-wide: 17,444
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  • Site-wide: 13,846

BAGSE: a Bayesian hierarchical model approach for gene set enrichment analysis

• Downloaded 396 times
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  • Site-wide: 63,489
  • In bioinformatics: 6,216
• Year to date:
  • Site-wide: 102,071
• Since beginning of last month:
  • Site-wide: 75,797

Psychosocial experiences modulate asthma-associated genes through gene-environment interactions

• Downloaded 274 times
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  • Site-wide: 85,579
  • In genomics: 5,477
• Year to date:
  • Site-wide: 40,223
• Since beginning of last month:
  • Site-wide: 31,386