Author: Patrick R Griffin

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Preprints

Structural basis for the RNA-guided ribonuclease activity of CRISPR-Cas13d

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Defining a canonical ligand-binding pocket in the orphan nuclear receptor Nurr1

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  • In biophysics: 425
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The SERM/SERD Bazedoxifene Disrupts ESR1 Helix 12 to Overcome Acquired Hormone Resistance in Breast Cancer Cells

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  • In cancer biology: 1,096
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Structures of the Human LONP1 Protease Reveal Regulatory Steps Involved in Protease Activation

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  • In molecular biology: 1,176
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Structural basis of altered potency and efficacy displayed by a major in vivo metabolite of the anti-diabetic PPARγ drug pioglitazone

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  • In biochemistry: 1,452
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Quantitative Structural Assessment of Graded Receptor Agonism

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  • In biophysics: 2,315
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Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calmodulin (CaM) Effector in Mouse Brain

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  • In biochemistry: 1,748
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HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists

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  • In biophysics: 2,877
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A Simple and Robust Cell Based Assay for the Discovery of Novel Cytokinesis Inhibitors

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  • In cell biology: 4,076
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Dual-mechanism estrogen receptor inhibitors expand the repertoire of anti-hormone therapy for breast cancer

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  • In cancer biology: 2,802
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PPARG in osteocytes is essential for sclerostin expression, bone mass, marrow adiposity and TZD-induced bone loss

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  • Site-wide: 107,794
  • In physiology: 1,206
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Discovery of a Novel, Selective and Short-Acting Skeletal Myosin II Inhibitor

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  • In pharmacology and toxicology: 1,014
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