Author: Andrew P Morris

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Preprints

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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  • Site-wide: 85,555

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 3,524
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  • Site-wide: 37,864

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

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  • Site-wide: 3,960
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Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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  • Site-wide: 7,371
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  • Site-wide: 92,835

Identification of type 2 diabetes loci in 433,540 East Asian individuals

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  • Site-wide: 7,856
  • In genetics: 395
• Year to date:
  • Site-wide: 9,830
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Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries

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  • Site-wide: 8,828
  • In genetics: 454
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  • Site-wide: 32,538
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PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

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• Year to date:
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New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

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  • In genomics: 1,079
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Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

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Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

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  • Site-wide: 11,161
  • In genetics: 571
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  • Site-wide: 62,065
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  • Site-wide: 57,417

Integrative cross tissue analysis of gene expression identifies novel type 2 diabetes genes

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  • Site-wide: 11,177
  • In genetics: 574
• Year to date:
  • Site-wide: 22,029
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  • Site-wide: 44,763

Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis

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  • Site-wide: 14,321
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  • Site-wide: 30,345

The genetic architecture of sporadic and recurrent miscarriage

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  • Site-wide: 16,179
  • In genetics: 842
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Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis

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  • Site-wide: 21,161
  • In genomics: 2,158
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  • Site-wide: 9,891
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  • Site-wide: 15,760

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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  • Site-wide: 23,136
  • In genetic and genomic medicine: 61
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  • Site-wide: 5,085

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

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  • In genetics: 1,308
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  • Site-wide: 100,574

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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  • Site-wide: 26,889
  • In genetics: 1,366
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MR-TRYX: A Mendelian randomization framework that exploits horizontal pleiotropy to infer novel causal pathways

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  • Site-wide: 27,271
  • In bioinformatics: 3,251
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  • Site-wide: 43,271
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  • Site-wide: 55,934

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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  • Site-wide: 28,333
  • In genomics: 2,651
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  • Site-wide: 96,086

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

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  • Site-wide: 30,228
  • In genetics: 1,540
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The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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  • Site-wide: 16,606
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Genome Wide Association Scan identifies new variants associated with a cognitive predictor of dyslexia.

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  • Site-wide: 37,666
  • In genomics: 3,232
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Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

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  • Site-wide: 38,319
  • In genetics: 1,900
• Year to date:
  • Site-wide: 56,919
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  • Site-wide: 54,114

Hypertension and renin-angiotensin system blockers are not associated with expression of Angiotensin Converting Enzyme 2 (ACE2) in the kidney

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  • Site-wide: 43,991
  • In cardiovascular medicine: 57
• Year to date:
  • Site-wide: 83,410
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  • Site-wide: 32,602

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 468 times
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  • Site-wide: 50,166
  • In genetics: 2,454
• Year to date:
  • Site-wide: 41,410
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  • Site-wide: 107,947

methylSCOPA and META-methylSCOPA: software for the analysis and aggregation of epigenome-wide association studies of multiple correlated phenotypes

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  • Site-wide: 72,434
  • In bioinformatics: 6,907
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  • Site-wide: 41,630
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  • Site-wide: 109,849

Chromatin-based techniques map DNA interaction landscapes in psoriasis susceptibility loci and highlight KLF4 as a target gene in 9q31

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  • Site-wide: 80,713
  • In genomics: 5,288
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  • Site-wide: 101,753

Discovery and fine-mapping of kidney function loci in first genome-wide association study in Africans

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  • Site-wide: 82,087
  • In genetics: 3,846
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  • Site-wide: None
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  • Site-wide: 67,169

Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability

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  • Site-wide: 106,623
  • In rheumatology: 67
• Year to date:
  • Site-wide: 4,897
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  • Site-wide: 4,235

Obesity as a cause of kidney disease - insights from Mendelian randomisation studies

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  • Site-wide: 115,105
  • In endocrinology: 101
• Year to date:
  • Site-wide: 63,111
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  • Site-wide: 44,592