Author: 23andMe Research Team

Downloads per author, site-wide

Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

• Downloaded 9,364 times
• Download rankings, all-time:
  • Site-wide: 818
  • In genetics: 25
• Year to date:
  • Site-wide: 23,229
• Since beginning of last month:
  • Site-wide: 26,057

MTAG: Multi-Trait Analysis of GWAS

• Downloaded 6,628 times
• Download rankings, all-time:
  • Site-wide: 1,257
  • In genomics: 122
• Year to date:
  • Site-wide: 18,314
• Since beginning of last month:
  • Site-wide: 20,918

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

• Downloaded 4,504 times
• Download rankings, all-time:
  • Site-wide: 2,160
  • In genetics: 83
• Year to date:
  • Site-wide: 25,034
• Since beginning of last month:
  • Site-wide: 19,067

LDpred-funct: incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets

• Downloaded 4,463 times
• Download rankings, all-time:
  • Site-wide: 2,191
  • In genetics: 84
• Year to date:
  • Site-wide: 4,147
• Since beginning of last month:
  • Site-wide: 5,939

Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson’s Disease

• Downloaded 4,103 times
• Download rankings, all-time:
  • Site-wide: 2,452
  • In genomics: 283
• Year to date:
  • Site-wide: 8,683
• Since beginning of last month:
  • Site-wide: 6,941

Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations

• Downloaded 2,436 times
• Download rankings, all-time:
  • Site-wide: 5,246
  • In genetics: 247
• Year to date:
  • Site-wide: 6,188
• Since beginning of last month:
  • Site-wide: 5,546

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

• Downloaded 1,867 times
• Download rankings, all-time:
  • Site-wide: 7,725
  • In genetics: 369
• Year to date:
  • Site-wide: 63,230
• Since beginning of last month:
  • Site-wide: 63,797

Largest GWAS (N=1,126,563) of Alzheimer's Disease Implicates Microglia and Immune Cells

• Downloaded 1,674 times
• Download rankings, all-time:
  • Site-wide: 9,160
  • In genetic and genomic medicine: 26
• Year to date:
  • Site-wide: 2,379
• Since beginning of last month:
  • Site-wide: 2,182

Genetic predisposition to mosaic Y chromosome loss in blood is associated with genomic instability in other tissues and susceptibility to non-haematological cancers

• Downloaded 1,350 times
• Download rankings, all-time:
  • Site-wide: 12,558
  • In genetics: 631
• Year to date:
  • Site-wide: 48,777
• Since beginning of last month:
  • Site-wide: 43,996

Genetic predisposition to myeloproliferative neoplasms implicates hematopoietic stem cell biology

• Downloaded 1,193 times
• Download rankings, all-time:
  • Site-wide: 15,123
  • In genetics: 774
• Year to date:
  • Site-wide: 21,117
• Since beginning of last month:
  • Site-wide: 15,565

Characterization of prevalence and health consequences of uniparental disomy in four million individuals from the general population

• Downloaded 1,188 times
• Download rankings, all-time:
  • Site-wide: 15,223
  • In genomics: 1,602
• Year to date:
  • Site-wide: 60,759
• Since beginning of last month:
  • Site-wide: 36,895

Large-Scale Genome-Wide Meta Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria.

• Downloaded 1,054 times
• Download rankings, all-time:
  • Site-wide: 18,221
  • In genetics: 915
• Year to date:
  • Site-wide: 69,028
• Since beginning of last month:
  • Site-wide: 40,847

Genome-wide association and multi-omic analyses reveal new mechanisms for Heart Failure

• Downloaded 974 times
• Download rankings, all-time:
  • Site-wide: 20,449
  • In genetic and genomic medicine: 63
• Year to date:
  • Site-wide: 35,478
• Since beginning of last month:
  • Site-wide: 30,683

Validity of the Cold Pressor Test and Pain Sensitivity Questionnaire via online self-administration

• Downloaded 876 times
• Download rankings, all-time:
  • Site-wide: 23,841
  • In pain medicine: 5
• Year to date:
  • Site-wide: 11,673
• Since beginning of last month:
  • Site-wide: 8,935

A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma and includes a genetic link with Alzheimer's disease

• Downloaded 798 times
• Download rankings, all-time:
  • Site-wide: 27,144
  • In genetics: 1,351
• Year to date:
  • Site-wide: 28,260
• Since beginning of last month:
  • Site-wide: None

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

• Downloaded 711 times
• Download rankings, all-time:
  • Site-wide: 31,911
  • In genetics: 1,589
• Year to date:
  • Site-wide: 104,864
• Since beginning of last month:
  • Site-wide: 89,472

A two-stage approach to identifying and validating modifiable factors for the prevention of depression

• Downloaded 689 times
• Download rankings, all-time:
  • Site-wide: 33,305
  • In genetics: 1,642
• Year to date:
  • Site-wide: 113,631
• Since beginning of last month:
  • Site-wide: None

Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

• Downloaded 662 times
• Download rankings, all-time:
  • Site-wide: 35,157
  • In genetics: 1,716
• Year to date:
  • Site-wide: 68,941
• Since beginning of last month:
  • Site-wide: 48,154

Symptom-level genetic modelling identifies novel risk loci and unravels the shared genetic architecture of anxiety and depression

• Downloaded 654 times
• Download rankings, all-time:
  • Site-wide: 35,724
  • In genetic and genomic medicine: 105
• Year to date:
  • Site-wide: 22,091
• Since beginning of last month:
  • Site-wide: 16,157

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

• Downloaded 551 times
• Download rankings, all-time:
  • Site-wide: 44,380
  • In genetics: 2,135
• Year to date:
  • Site-wide: 41,075
• Since beginning of last month:
  • Site-wide: 53,508

Accelerated Epigenetic Ageing in Major Depressive Disorder

• Downloaded 524 times
• Download rankings, all-time:
  • Site-wide: 47,076
  • In genomics: 3,807
• Year to date:
  • Site-wide: 81,633
• Since beginning of last month:
  • Site-wide: 80,247

The Parkinsons Disease Mendelian Randomization Research Portal

• Downloaded 507 times
• Download rankings, all-time:
  • Site-wide: 48,925
  • In neuroscience: 7,253
• Year to date:
  • Site-wide: 82,001
• Since beginning of last month:
  • Site-wide: 72,915

Insight into the genetic aetiology of retinal detachment by combining small clinical and large population-based datasets

• Downloaded 499 times
• Download rankings, all-time:
  • Site-wide: 49,894
  • In genetics: 2,381
• Year to date:
  • Site-wide: 71,512
• Since beginning of last month:
  • Site-wide: 59,722

Expanded genomic analyses for male voice-breaking highlights a shared phenotypic and genetic basis between puberty timing and hair colour

• Downloaded 498 times
• Download rankings, all-time:
  • Site-wide: 50,012
  • In genomics: 3,955
• Year to date:
  • Site-wide: 75,133
• Since beginning of last month:
  • Site-wide: 74,984

Genetic determinants of daytime napping and effects on cardiometabolic health

• Downloaded 481 times
• Download rankings, all-time:
  • Site-wide: 51,996
  • In genetic and genomic medicine: 150
• Year to date:
  • Site-wide: 14,682
• Since beginning of last month:
  • Site-wide: 18,956

Overlapping Genetic Architecture between Parkinson Disease and Melanoma

• Downloaded 445 times
• Download rankings, all-time:
  • Site-wide: 56,556
  • In genetics: 2,683
• Year to date:
  • Site-wide: 69,622
• Since beginning of last month:
  • Site-wide: 75,194

Common variant burden contributes significantly to the familial aggregation of migraine in 1,589 families

• Downloaded 430 times
• Download rankings, all-time:
  • Site-wide: 58,635
  • In genetics: 2,779
• Year to date:
  • Site-wide: 113,683
• Since beginning of last month:
  • Site-wide: 79,804

Genome-wide association analysis and replication in 810,625 individuals identifies novel therapeutic targets for varicose veins

• Downloaded 428 times
• Download rankings, all-time:
  • Site-wide: 58,864
  • In genetics: 2,792
• Year to date:
  • Site-wide: 23,938
• Since beginning of last month:
  • Site-wide: 15,044

Fine-mapping of SNCA in REM sleep behavior disorder and overt synucleinopathies

• Downloaded 412 times
• Download rankings, all-time:
  • Site-wide: 61,317
  • In genetics: 2,911
• Year to date:
  • Site-wide: 41,820
• Since beginning of last month:
  • Site-wide: 28,596

Fox Insight Collects Online, Longitudinal Patient-Reported Outcomes and Genetic Data on Parkinson's Disease

• Downloaded 412 times
• Download rankings, all-time:
  • Site-wide: 61,309
  • In epidemiology: 2,600
• Year to date:
  • Site-wide: 90,743
• Since beginning of last month:
  • Site-wide: 68,372

Shared and distinct genetic influences between cognitive domains and psychiatric disorder risk based on genome-wide data

• Downloaded 378 times
• Download rankings, all-time:
  • Site-wide: 66,644
  • In genetics: 3,122
• Year to date:
  • Site-wide: 40,916
• Since beginning of last month:
  • Site-wide: 33,234

Demographic, spatial, and temporal dietary intake patterns among 526,774 23andMe research participants

• Downloaded 341 times
• Download rankings, all-time:
  • Site-wide: 72,810
  • In nutrition: 43
• Year to date:
  • Site-wide: 42,244
• Since beginning of last month:
  • Site-wide: 22,269

Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

• Downloaded 338 times
• Download rankings, all-time:
  • Site-wide: 73,459
  • In genetics: 3,417
• Year to date:
  • Site-wide: 109,580
• Since beginning of last month:
  • Site-wide: 88,966

Genome-wide analyses in 1,987,836 participants identify 39 genetic loci associated with sleep apnoea

• Downloaded 331 times
• Download rankings, all-time:
  • Site-wide: 74,771
  • In genetic and genomic medicine: 232
• Year to date:
  • Site-wide: 19,000
• Since beginning of last month:
  • Site-wide: 23,822

Genome-wide association study of pain sensitivity assessed by questionnaire and the cold pressor test

• Downloaded 312 times
• Download rankings, all-time:
  • Site-wide: 78,317
  • In genetics: 3,632
• Year to date:
  • Site-wide: 42,692
• Since beginning of last month:
  • Site-wide: 53,080

Genome-wide meta-analysis of insomnia in over 2.3 million individuals indicates involvement of specific biological pathways through gene-prioritization

• Downloaded 255 times
• Download rankings, all-time:
  • Site-wide: 89,997
  • In psychiatry and clinical psychology: 305
• Year to date:
  • Site-wide: 21,830
• Since beginning of last month:
  • Site-wide: 16,266