Author: Danielle Posthuma

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 809
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  • Site-wide: 20,448
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  • Site-wide: 20,448

Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use

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  • Site-wide: 904
  • In genetics: 27
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  • Site-wide: 44,249
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The genetic architecture of the human cerebral cortex

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  • Site-wide: 1,003
  • In genetics: 30
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  • Site-wide: 14,383
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Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 1,130
  • In genetics: 38
• Year to date:
  • Site-wide: 20,413
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  • Site-wide: 20,413

Genome-wide Analysis of Insomnia (N=1,331,010) Identifies Novel Loci and Functional Pathways

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  • Site-wide: 1,744
  • In genetics: 64
• Year to date:
  • Site-wide: 18,263
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  • Site-wide: 18,263

Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimers disease risk

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  • Site-wide: 1,750
  • In genetics: 66
• Year to date:
  • Site-wide: 22,569
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GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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  • Site-wide: 1,775
  • In genetics: 67
• Year to date:
  • Site-wide: 22,485
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Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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  • Site-wide: 2,012
  • In genomics: 215
• Year to date:
  • Site-wide: 10,788
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  • Site-wide: 10,788

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

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  • Site-wide: 3,083
  • In genetics: 124
• Year to date:
  • Site-wide: 27,701
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  • Site-wide: 27,701

GWAS of brain volume on 54,407 individuals and cross-trait analysis with intelligence identifies shared genomic loci and genes

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  • Site-wide: 3,750
  • In genetics: 168
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  • Site-wide: 35,607
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A global view of pleiotropy and genetic architecture in complex traits

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  • Site-wide: 4,775
  • In genetics: 221
• Year to date:
  • Site-wide: 50,356
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  • Site-wide: 50,356

Common variants in Alzheimer's disease: Novel association of six genetic variants with AD and risk stratification by polygenic risk scores

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  • Site-wide: 5,483
  • In genetic and genomic medicine: 15
• Year to date:
  • Site-wide: 7,745
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  • Site-wide: 7,745

FUMA: Functional mapping and annotation of genetic associations

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  • Site-wide: 5,561
  • In bioinformatics: 647
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GWAS Meta-Analysis of Neuroticism (N=449,484) Identifies Novel Genetic Loci and Pathways

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  • Site-wide: 5,968
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Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits

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  • Site-wide: 6,189
  • In genetics: 304
• Year to date:
  • Site-wide: 7,146
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  • Site-wide: 7,146

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 8,272
  • In genetics: 407
• Year to date:
  • Site-wide: 31,224
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  • Site-wide: 31,224

Largest GWAS (N=1,126,563) of Alzheimer's Disease Implicates Microglia and Immune Cells

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  • Site-wide: 9,055
  • In genetic and genomic medicine: 26
• Year to date:
  • Site-wide: 1,937
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  • Site-wide: 1,937

Genome-wide association study of over 40,000 bipolar disorder cases provides novel biological insights

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  • Site-wide: 10,057
  • In psychiatry and clinical psychology: 32
• Year to date:
  • Site-wide: 2,274
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  • Site-wide: 2,274

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 11,226
  • In genomics: 1,253
• Year to date:
  • Site-wide: 65,710
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  • Site-wide: 65,710

Exploring the genetic correlations of antisocial behavior and life history traits

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  • Site-wide: 14,410
  • In genomics: 1,533
• Year to date:
  • Site-wide: 65,529
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  • Site-wide: 65,529

Functional consequences of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals

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  • Site-wide: 18,855
  • In genomics: 1,939
• Year to date:
  • Site-wide: 81,197
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  • Site-wide: 81,197

An epigenome-wide association study of educational attainment (n = 10,767)

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  • Site-wide: 20,072
  • In genetics: 1,001
• Year to date:
  • Site-wide: 50,379
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  • Site-wide: 50,379

Rare copy number variants in NRXN1 and CNTN6 increase risk for Tourette syndrome

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  • Site-wide: 20,911
  • In genetics: 1,035
• Year to date:
  • Site-wide: 92,424
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  • Site-wide: 92,424

The more the merrier? Multivariate approaches to genome-wide association analysis

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  • Site-wide: 21,745
  • In genetics: 1,074
• Year to date:
  • Site-wide: 53,560
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  • Site-wide: 53,560

Genetic association study of psychotic experiences in UK Biobank

• Downloaded 773 times
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  • Site-wide: 28,026
  • In genetics: 1,402
• Year to date:
  • Site-wide: 50,019
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  • Site-wide: 50,019

Planar cell polarity pathway and development of the human visual cortex

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  • Site-wide: 28,889
  • In neuroscience: 3,959
• Year to date:
  • Site-wide: 37,252
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  • Site-wide: 37,252

Lipid associated polygenic enrichment in Alzheimer's disease

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  • Site-wide: 29,016
  • In genetics: 1,446
• Year to date:
  • Site-wide: 28,774
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  • Site-wide: 28,774

LAVA: An integrated framework for local genetic correlation analysis

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  • Site-wide: 41,414
  • In genetics: 1,993
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  • Site-wide: 901
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  • Site-wide: 901

Exome chip meta-analysis elucidates the genetic architecture of rare coding variants in smoking and drinking behavior

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  • Site-wide: 41,986
  • In genetics: 2,022
• Year to date:
  • Site-wide: 100,578
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  • Site-wide: 100,578

Quantitative proteomic alterations of human iPSC-based neuronal development indicate early onset of Rett syndrome.

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  • Site-wide: 49,708
  • In neuroscience: 7,382
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  • Site-wide: None
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Genetic correlates of evolutionary adaptations in cognitive functional brain networks and their relationship to human cognitive functioning and disease

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  • Site-wide: 51,725
  • In neuroscience: 7,743
• Year to date:
  • Site-wide: 86,079
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  • Site-wide: 86,079

A response to Yurko et al: H-MAGMA, inheriting a shaky statistical foundation, yields excess false positives

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  • Site-wide: 81,781
  • In genomics: 5,315
• Year to date:
  • Site-wide: 34,624
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  • Site-wide: 34,624

Genome-wide meta-analysis of insomnia in over 2.3 million individuals indicates involvement of specific biological pathways through gene-prioritization

• Downloaded 255 times
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  • Site-wide: 89,362
  • In psychiatry and clinical psychology: 304
• Year to date:
  • Site-wide: 17,902
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  • Site-wide: 17,902

Gene expression imputation provides insight into the genetic architecture of frontotemporal dementia

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  • Site-wide: 96,349
  • In genetics: 4,394
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  • Site-wide: 44,845
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  • Site-wide: 44,845