Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 62,747 bioRxiv papers from 278,434 authors.

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • In genetics: 13 out of 3,562
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  • Site-wide: 9,234 out of 62,747

New mutations, old statistical challenges

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  • Site-wide: 232 out of 62,747
  • In genetics: 24 out of 3,562
• Year to date:
  • Site-wide: 15,443 out of 62,747
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  • Site-wide: 18,890 out of 62,747

Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 282 out of 62,747
  • In genetics: 32 out of 3,562
• Year to date:
  • Site-wide: 292 out of 62,747
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  • Site-wide: 2,143 out of 62,747

Regulatory variants explain much more heritability than coding variants across 11 common diseases

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  • Site-wide: 555 out of 62,747
  • In genetics: 60 out of 3,562
• Year to date:
  • Site-wide: 25,966 out of 62,747
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  • Site-wide: 22,736 out of 62,747

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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  • Site-wide: 738 out of 62,747
  • In genetics: 72 out of 3,562
• Year to date:
  • Site-wide: 435 out of 62,747
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  • Site-wide: 2,710 out of 62,747

Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

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  • In genetics: 104 out of 3,562
• Year to date:
  • Site-wide: 36,321 out of 62,747
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  • Site-wide: 40,630 out of 62,747

Haplotypes of common SNPs can explain missing heritability of complex diseases

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  • In genetics: 106 out of 3,562
• Year to date:
  • Site-wide: 36,119 out of 62,747
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  • Site-wide: 34,757 out of 62,747

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

• Downloaded 2,893 times
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  • Site-wide: 1,160 out of 62,747
  • In genomics: 274 out of 4,316
• Year to date:
  • Site-wide: 190 out of 62,747
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  • Site-wide: 1,693 out of 62,747

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

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  • Site-wide: 1,305 out of 62,747
  • In genomics: 301 out of 4,316
• Year to date:
  • Site-wide: 1,944 out of 62,747
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  • Site-wide: 3,808 out of 62,747

Commentary on "Limitations of GCTA as a solution to the missing heritability problem"

• Downloaded 2,505 times
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  • In genetics: 146 out of 3,562
• Year to date:
  • Site-wide: 28,073 out of 62,747
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  • Site-wide: 32,719 out of 62,747

Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection

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  • Site-wide: 1,704 out of 62,747
  • In genomics: 378 out of 4,316
• Year to date:
  • Site-wide: 38,955 out of 62,747
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  • Site-wide: 23,869 out of 62,747

A comparative study of techniques for differential expression analysis on RNA-Seq data

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  • Site-wide: 1,703 out of 62,747
  • In bioinformatics: 344 out of 6,251
• Year to date:
  • Site-wide: 16,471 out of 62,747
• Since beginning of last month:
  • Site-wide: 11,990 out of 62,747

Improved polygenic prediction by Bayesian multiple regression on summary statistics

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  • Site-wide: 2,115 out of 62,747
  • In genetics: 205 out of 3,562
• Year to date:
  • Site-wide: 374 out of 62,747
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  • Site-wide: 692 out of 62,747

Widespread signatures of negative selection in the genetic architecture of human complex traits

• Downloaded 2,047 times
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  • Site-wide: 2,140 out of 62,747
  • In genetics: 208 out of 3,562
• Year to date:
  • Site-wide: 35,956 out of 62,747
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  • Site-wide: 37,779 out of 62,747

GWAS on family history of Alzheimer's disease

• Downloaded 1,748 times
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  • Site-wide: 2,815 out of 62,747
  • In genetics: 252 out of 3,562
• Year to date:
  • Site-wide: 17,183 out of 62,747
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  • Site-wide: 21,832 out of 62,747

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

• Downloaded 1,601 times
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  • Site-wide: 3,254 out of 62,747
  • In genetics: 286 out of 3,562
• Year to date:
  • Site-wide: 45,916 out of 62,747
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  • Site-wide: 48,814 out of 62,747

Causal associations between risk factors and common diseases inferred from GWAS summary data

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  • Site-wide: 3,318 out of 62,747
  • In genetics: 292 out of 3,562
• Year to date:
  • Site-wide: 40,043 out of 62,747
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  • Site-wide: 46,807 out of 62,747

A resource-efficient tool for mixed model association analysis of large-scale data

• Downloaded 1,338 times
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  • Site-wide: 4,390 out of 62,747
  • In genetics: 370 out of 3,562
• Year to date:
  • Site-wide: 867 out of 62,747
• Since beginning of last month:
  • Site-wide: 447 out of 62,747

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

• Downloaded 1,276 times
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  • Site-wide: 4,741 out of 62,747
  • In genomics: 839 out of 4,316
• Year to date:
  • Site-wide: 19,322 out of 62,747
• Since beginning of last month:
  • Site-wide: 37,660 out of 62,747

Imprint of Assortative Mating on the Human Genome

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  • Site-wide: 6,127 out of 62,747
  • In genetics: 494 out of 3,562
• Year to date:
  • Site-wide: 12,104 out of 62,747
• Since beginning of last month:
  • Site-wide: 26,038 out of 62,747

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

• Downloaded 1,039 times
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  • Site-wide: 6,681 out of 62,747
  • In genetics: 538 out of 3,562
• Year to date:
  • Site-wide: 1,389 out of 62,747
• Since beginning of last month:
  • Site-wide: 6,880 out of 62,747

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

• Downloaded 974 times
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  • Site-wide: 7,375 out of 62,747
  • In bioinformatics: 1,333 out of 6,251
• Year to date:
  • Site-wide: 7,367 out of 62,747
• Since beginning of last month:
  • Site-wide: 30,008 out of 62,747

OSCA: a tool for omic-data-based complex trait analysis

• Downloaded 947 times
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  • Site-wide: 7,714 out of 62,747
  • In bioinformatics: 1,372 out of 6,251
• Year to date:
  • Site-wide: 3,774 out of 62,747
• Since beginning of last month:
  • Site-wide: 23,336 out of 62,747

Estimation of genetic correlation using linkage disequilibrium score regression and genomic restricted maximum likelihood

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  • Site-wide: 8,295 out of 62,747
  • In genetics: 626 out of 3,562
• Year to date:
  • Site-wide: 34,635 out of 62,747
• Since beginning of last month:
  • Site-wide: 40,144 out of 62,747

Identification of 55,000 Replicated DNA Methylation QTL

• Downloaded 867 times
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  • Site-wide: 8,881 out of 62,747
  • In genomics: 1,351 out of 4,316
• Year to date:
  • Site-wide: 31,956 out of 62,747
• Since beginning of last month:
  • Site-wide: 40,569 out of 62,747

Epigenetic prediction of complex traits and death

• Downloaded 854 times
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  • Site-wide: 9,114 out of 62,747
  • In genomics: 1,384 out of 4,316
• Year to date:
  • Site-wide: 38,869 out of 62,747
• Since beginning of last month:
  • Site-wide: 48,667 out of 62,747

The Project MinE databrowser: bringing large-scale whole-genome sequencing in ALS to researchers and the public

• Downloaded 775 times
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  • Site-wide: 10,514 out of 62,747
  • In genomics: 1,509 out of 4,316
• Year to date:
  • Site-wide: 7,487 out of 62,747
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  • Site-wide: 25,986 out of 62,747

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

• Downloaded 697 times
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  • Site-wide: 12,293 out of 62,747
  • In genetics: 865 out of 3,562
• Year to date:
  • Site-wide: 36,381 out of 62,747
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  • Site-wide: 28,901 out of 62,747

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

• Downloaded 668 times
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  • Site-wide: 13,054 out of 62,747
  • In genetics: 921 out of 3,562
• Year to date:
  • Site-wide: 29,120 out of 62,747
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  • Site-wide: 36,840 out of 62,747

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

• Downloaded 662 times
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  • Site-wide: 13,228 out of 62,747
  • In genetics: 932 out of 3,562
• Year to date:
  • Site-wide: 10,420 out of 62,747
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  • Site-wide: 29,403 out of 62,747

Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

• Downloaded 656 times
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  • Site-wide: 13,380 out of 62,747
  • In genetics: 942 out of 3,562
• Year to date:
  • Site-wide: None out of 62,747
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  • Site-wide: None out of 62,747

Bayesian reassessment of the epigenetic architecture of complex traits

• Downloaded 630 times
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  • Site-wide: 14,123 out of 62,747
  • In genomics: 1,862 out of 4,316
• Year to date:
  • Site-wide: 10,805 out of 62,747
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  • Site-wide: 13,406 out of 62,747

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

• Downloaded 576 times
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  • Site-wide: 15,977 out of 62,747
  • In genetics: 1,093 out of 3,562
• Year to date:
  • Site-wide: 16,816 out of 62,747
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  • Site-wide: 27,976 out of 62,747

DEAR-O: Differential Expression Analysis based on RNA-seq data - Online

• Downloaded 515 times
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  • Site-wide: 18,505 out of 62,747
  • In bioinformatics: 2,762 out of 6,251
• Year to date:
  • Site-wide: 51,636 out of 62,747
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  • Site-wide: 56,215 out of 62,747

Comparison of Genotypic and Phenotypic Correlations: Cheverud’s Conjecture in Humans

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  • Site-wide: 19,070 out of 62,747
  • In genetics: 1,278 out of 3,562
• Year to date:
  • Site-wide: 40,245 out of 62,747
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  • Site-wide: 35,362 out of 62,747

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

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  • Site-wide: 20,380 out of 62,747
  • In genetics: 1,366 out of 3,562
• Year to date:
  • Site-wide: 58,860 out of 62,747
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  • Site-wide: 60,671 out of 62,747

Genotype-covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model

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  • Site-wide: 20,578 out of 62,747
  • In genetics: 1,386 out of 3,562
• Year to date:
  • Site-wide: 21,952 out of 62,747
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  • Site-wide: 23,945 out of 62,747

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

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  • In genetics: 1,401 out of 3,562
• Year to date:
  • Site-wide: 5,553 out of 62,747
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  • Site-wide: 6,807 out of 62,747

Widespread associations between grey matter structure and the human phenome

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  • Site-wide: 22,696 out of 62,747
  • In neuroscience: 3,822 out of 11,207
• Year to date:
  • Site-wide: 6,205 out of 62,747
• Since beginning of last month:
  • Site-wide: 7,502 out of 62,747

Bayesian analysis of GWAS summary data reveals differential signatures of natural selection across human complex traits and functional genomic categories

• Downloaded 420 times
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  • Site-wide: 23,527 out of 62,747
  • In genetics: 1,559 out of 3,562
• Year to date:
  • Site-wide: 6,526 out of 62,747
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  • Site-wide: 254 out of 62,747

Age at first birth in women is genetically associated with increased risk of schizophrenia

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  • Site-wide: 24,658 out of 62,747
  • In genetics: 1,621 out of 3,562
• Year to date:
  • Site-wide: 27,468 out of 62,747
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  • Site-wide: 12,093 out of 62,747

A better design for stratified medicine based on genomic prediction

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  • Site-wide: 26,863 out of 62,747
  • In genetics: 1,746 out of 3,562
• Year to date:
  • Site-wide: 58,296 out of 62,747
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  • Site-wide: 55,966 out of 62,747

The Australian Genetics of Depression Study: Study Description and Sample Characteristics

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  • Site-wide: 27,202 out of 62,747
  • In genetics: 1,762 out of 3,562
• Year to date:
  • Site-wide: 8,195 out of 62,747
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  • Site-wide: 10,871 out of 62,747

Genetic analyses of medication-use and implications for precision medicine

• Downloaded 347 times
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  • Site-wide: 28,724 out of 62,747
  • In genetics: 1,845 out of 3,562
• Year to date:
  • Site-wide: 16,606 out of 62,747
• Since beginning of last month:
  • Site-wide: 35,226 out of 62,747

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

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  • Site-wide: 30,603 out of 62,747
  • In genetics: 1,954 out of 3,562
• Year to date:
  • Site-wide: 10,000 out of 62,747
• Since beginning of last month:
  • Site-wide: 43,569 out of 62,747

Exploring contributors to variability in estimates of SNP-heritability and genetic correlations from the iPSYCH case-cohort and published meta-studies of major psychiatric disorders.

• Downloaded 284 times
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  • Site-wide: 34,451 out of 62,747
  • In genetics: 2,154 out of 3,562
• Year to date:
  • Site-wide: 20,621 out of 62,747
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  • Site-wide: 37,884 out of 62,747

Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

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  • Site-wide: 35,969 out of 62,747
  • In neuroscience: 6,214 out of 11,207
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  • Site-wide: 13,297 out of 62,747
• Since beginning of last month:
  • Site-wide: 27,322 out of 62,747

Cross-disorder GWAS meta-analysis for Attention Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Obsessive Compulsive Disorder, and Tourette Syndrome

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  • Site-wide: 42,582 out of 62,747
  • In genetics: 2,585 out of 3,562
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  • Site-wide: 18,586 out of 62,747
• Since beginning of last month:
  • Site-wide: 981 out of 62,747

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

• Downloaded 201 times
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  • Site-wide: 43,847 out of 62,747
  • In epidemiology: 833 out of 1,556
• Year to date:
  • Site-wide: 39,823 out of 62,747
• Since beginning of last month:
  • Site-wide: 44,875 out of 62,747