Author: Naomi R. Wray

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 809
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  • Site-wide: 20,448
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  • Site-wide: 20,448

Genetic Consequences of Social Stratification in Great Britain

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  • Site-wide: 1,056
  • In genetics: 35
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  • Site-wide: 8,817
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  • Site-wide: 8,817

Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 1,130
  • In genetics: 38
• Year to date:
  • Site-wide: 20,413
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  • Site-wide: 20,413

New mutations, old statistical challenges

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  • Site-wide: 1,154
  • In genetics: 40
• Year to date:
  • Site-wide: 57,226
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  • Site-wide: 57,226

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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  • Site-wide: 2,012
  • In genomics: 215
• Year to date:
  • Site-wide: 10,788
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  • Site-wide: 10,788

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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  • Site-wide: 2,139
  • In genetics: 83
• Year to date:
  • Site-wide: 26,449
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  • Site-wide: 26,449

Regulatory variants explain much more heritability than coding variants across 11 common diseases

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  • Site-wide: 2,179
  • In genetics: 85
• Year to date:
  • Site-wide: 70,114
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  • Site-wide: 70,114

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

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  • Site-wide: 3,019
  • In genomics: 356
• Year to date:
  • Site-wide: 26,711
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  • Site-wide: 26,711

Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

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  • Site-wide: 3,578
  • In genetics: 157
• Year to date:
  • Site-wide: 41,219
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  • Site-wide: 41,219

Haplotypes of common SNPs can explain missing heritability of complex diseases

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  • Site-wide: 3,722
  • In genetics: 165
• Year to date:
  • Site-wide: 82,323
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  • Site-wide: 82,323

Commentary on "Limitations of GCTA as a solution to the missing heritability problem"

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  • Site-wide: 4,017
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  • Site-wide: 28,669
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  • Site-wide: 28,669

Improved polygenic prediction by Bayesian multiple regression on summary statistics

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  • Site-wide: 4,311
  • In genetics: 198
• Year to date:
  • Site-wide: 83,455
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  • Site-wide: 83,455

A resource-efficient tool for mixed model association analysis of large-scale data

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  • Site-wide: 4,577
  • In genetics: 212
• Year to date:
  • Site-wide: 15,429
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  • Site-wide: 15,429

A comparative study of techniques for differential expression analysis on RNA-Seq data

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  • Site-wide: 4,876
  • In bioinformatics: 553
• Year to date:
  • Site-wide: 93,409
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  • Site-wide: 93,409

Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection

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  • Site-wide: 5,005
  • In genomics: 590
• Year to date:
  • Site-wide: 70,792
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  • Site-wide: 70,792

GWAS on family history of Alzheimer's disease

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  • Site-wide: 7,057
  • In genetics: 345
• Year to date:
  • Site-wide: 62,512
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  • Site-wide: 62,512

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 8,272
  • In genetics: 407
• Year to date:
  • Site-wide: 31,224
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  • Site-wide: 31,224

Causal associations between risk factors and common diseases inferred from GWAS summary data

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  • Site-wide: 8,322
  • In genetics: 410
• Year to date:
  • Site-wide: 77,032
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  • Site-wide: 77,032

Genome-wide association study of over 40,000 bipolar disorder cases provides novel biological insights

• Downloaded 1,557 times
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  • Site-wide: 10,057
  • In psychiatry and clinical psychology: 32
• Year to date:
  • Site-wide: 2,274
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  • Site-wide: 2,274

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

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  • Site-wide: 10,963
  • In genetics: 546
• Year to date:
  • Site-wide: 39,749
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  • Site-wide: 39,749

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

• Downloaded 1,442 times
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  • Site-wide: 11,226
  • In genomics: 1,253
• Year to date:
  • Site-wide: 65,710
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  • Site-wide: 65,710

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

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  • Site-wide: 11,365
  • In genetics: 566
• Year to date:
  • Site-wide: 13,990
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  • Site-wide: 13,990

A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder

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  • Site-wide: 11,848
  • In genetics: 597
• Year to date:
  • Site-wide: 37,656
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  • Site-wide: 37,656

Bayesian reassessment of the epigenetic architecture of complex traits

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  • Site-wide: 12,838
  • In genomics: 1,406
• Year to date:
  • Site-wide: 100,745
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  • Site-wide: 100,745

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

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  • Site-wide: 13,306
  • In bioinformatics: 1,642
• Year to date:
  • Site-wide: 50,340
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  • Site-wide: 50,340

Imprint of Assortative Mating on the Human Genome

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  • Site-wide: 13,604
  • In genetics: 701
• Year to date:
  • Site-wide: 114,446
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  • Site-wide: 114,446

Bayesian analysis of GWAS summary data reveals differential signatures of natural selection across human complex traits and functional genomic categories

• Downloaded 1,266 times
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  • Site-wide: 13,680
  • In genetics: 704
• Year to date:
  • Site-wide: 20,431
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  • Site-wide: 20,431

Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

• Downloaded 1,191 times
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  • Site-wide: 15,014
  • In genetics: 773
• Year to date:
  • Site-wide: 70,318
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  • Site-wide: 70,318

Estimation of genetic correlation using linkage disequilibrium score regression and genomic restricted maximum likelihood

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  • Site-wide: 17,251
  • In genetics: 877
• Year to date:
  • Site-wide: 72,128
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  • Site-wide: 72,128

Using genotype data to distinguish pleiotropy from heterogeneity: deciphering coheritability in autoimmune and neuropsychiatric diseases

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  • Site-wide: 18,399
  • In genomics: 1,894
• Year to date:
  • Site-wide: 78,085
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  • Site-wide: 78,085

Identification of 55,000 Replicated DNA Methylation QTL

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  • Site-wide: 18,469
  • In genomics: 1,902
• Year to date:
  • Site-wide: 65,711
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  • Site-wide: 65,711

Epigenetic prediction of complex traits and death

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  • Site-wide: 19,987
  • In genomics: 2,026
• Year to date:
  • Site-wide: 69,193
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  • Site-wide: 69,193

A comprehensive evaluation of polygenic score methods across cohorts in psychiatric disorders

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  • Site-wide: 22,231
  • In genetic and genomic medicine: 67
• Year to date:
  • Site-wide: 4,463
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  • Site-wide: 4,463

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

• Downloaded 831 times
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  • Site-wide: 25,371
  • In genetics: 1,262
• Year to date:
  • Site-wide: 60,835
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  • Site-wide: 60,835

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

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  • Site-wide: 26,137
  • In genetics: 1,304
• Year to date:
  • Site-wide: 108,644
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  • Site-wide: 108,644

Genetic Association Study of Childhood Aggression across raters, instruments and age

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  • Site-wide: 26,943
  • In genomics: 2,544
• Year to date:
  • Site-wide: 29,071
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  • Site-wide: 29,071

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

• Downloaded 787 times
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  • Site-wide: 27,349
  • In genetics: 1,361
• Year to date:
  • Site-wide: 81,841
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  • Site-wide: 81,841

Widespread associations between grey matter structure and the human phenome

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  • Site-wide: 27,478
  • In neuroscience: 3,743
• Year to date:
  • Site-wide: 86,198
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  • Site-wide: 86,198

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.

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  • Site-wide: 29,475
  • In genetics: 1,468
• Year to date:
  • Site-wide: 88,153
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  • Site-wide: 88,153

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

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  • Site-wide: 31,530
  • In genetics: 1,572
• Year to date:
  • Site-wide: 96,190
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  • Site-wide: 96,190

Cross-disorder GWAS meta-analysis for Attention Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Obsessive Compulsive Disorder, and Tourette Syndrome

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  • Site-wide: 31,929
  • In genetics: 1,598
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  • Site-wide: 33,721
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  • Site-wide: 33,721

Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

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  • Site-wide: 33,438
  • In genetics: 1,651
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  • Site-wide: 17,050
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  • Site-wide: 17,050

Genotype-covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model

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  • Site-wide: 35,333
  • In genetics: 1,737
• Year to date:
  • Site-wide: 86,578
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  • Site-wide: 86,578

The Australian Genetics of Depression Study: Study Description and Sample Characteristics

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  • Site-wide: 36,910
  • In genetics: 1,806
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  • Site-wide: 85,762
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  • Site-wide: 85,762

Genome-wide association study of gastrointestinal disorders reinforces the link between the digestive tract and the nervous system

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  • Site-wide: 40,133
  • In genomics: 3,359
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  • Site-wide: 29,203
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  • Site-wide: 29,203

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

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  • Site-wide: 41,848
  • In genetics: 2,017
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  • Site-wide: 97,520
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  • Site-wide: 97,520

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

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  • Site-wide: 42,454
  • In genetics: 2,049
• Year to date:
  • Site-wide: 107,515
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  • Site-wide: 107,515

Investigating the potential effect of antihypertensive medication on psychiatric disorders: a mendelian randomisation study

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  • Site-wide: 43,735
  • In genetic and genomic medicine: 124
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  • Site-wide: 19,824
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  • Site-wide: 19,824

Exploring contributors to variability in estimates of SNP-heritability and genetic correlations from the iPSYCH case-cohort and published meta-studies of major psychiatric disorders.

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  • Site-wide: 45,927
  • In genetics: 2,213
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  • Site-wide: 77,414
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  • Site-wide: 77,414

Genetic analyses of medication-use and implications for precision medicine

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  • Site-wide: 47,161
  • In genetics: 2,267
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  • Site-wide: 61,677
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  • Site-wide: 61,677

Age at first birth in women is genetically associated with increased risk of schizophrenia

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  • Site-wide: 51,015
  • In genetics: 2,438
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  • Site-wide: 120,048
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  • Site-wide: 120,048

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

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  • Site-wide: 51,095
  • In genetics: 2,445
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  • Site-wide: 11,784
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  • Site-wide: 11,784

Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults

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  • Site-wide: 55,814
  • In genomics: 4,247
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  • Site-wide: 87,102
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  • Site-wide: 87,102

Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction

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  • Site-wide: 57,058
  • In genetics: 2,703
• Year to date:
  • Site-wide: 25,539
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  • Site-wide: 25,539

A better design for stratified medicine based on genomic prediction

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  • Site-wide: 57,098
  • In genetics: 2,708
• Year to date:
  • Site-wide: 119,899
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  • Site-wide: 119,899

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

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  • Site-wide: 60,423
  • In genetic and genomic medicine: 180
• Year to date:
  • Site-wide: 8,845
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  • Site-wide: 8,845

Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

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  • Site-wide: 65,585
  • In neuroscience: 10,038
• Year to date:
  • Site-wide: 118,334
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  • Site-wide: 118,334

Rare Genetic Variants Underlie Outlying levels of DNA Methylation and Gene-Expression

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  • Site-wide: 73,118
  • In genetics: 3,412
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  • Site-wide: 58,312
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  • Site-wide: 58,312

Antidepressant Response in Major Depressive Disorder: A Genome-wide Association Study

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  • Site-wide: 79,104
  • In psychiatry and clinical psychology: 245
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  • Site-wide: 4,879
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  • Site-wide: 4,879

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

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  • Site-wide: 84,038
  • In epidemiology: 3,436
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  • Site-wide: 118,533
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  • Site-wide: 118,533

A parsimonious model for mass-univariate vertex-wise analysis

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  • Site-wide: 107,623
  • In neuroscience: 16,787
• Year to date:
  • Site-wide: 4,966
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  • Site-wide: 4,966