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Author: Timothy M. Frayling

  • ORCiD: http://orcid.org/0000-0001-8362-2603
  • Most recently observed institution: Genetics of Human Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, U.K

Rankings

  • All-time downloads: 53,457 (rank: 2,607 )
  • Categories:
    • epidemiology: 4,123 (rank: 2,817 )
    • genetic and genomic medicine: 1,274 (rank: 1,472 )
    • genetics: 38,575 (rank: 122 )
    • genomics: 8,599 (rank: 2,273 )
    • orthopedics: 299 (rank: 115 (tie) )
    • sexual and reproductive health: 587 (rank: 184 (tie) )

Downloads per author, site-wide

Preprints

Genetic Consequences of Social Stratification in Great Britain

genetics more details view paper
  • Downloaded 7,745 times
  • Download rankings, all-time:
    • Site-wide: 1,117
    • In genetics: 35
  • Year to date:
    • Site-wide: 10,089
  • Since beginning of last month:
    • Site-wide: 10,090

Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry

genetics more details view paper
  • Downloaded 6,620 times
  • Download rankings, all-time:
    • Site-wide: 1,354
    • In genetics: 46
  • Year to date:
    • Site-wide: 18,902
  • Since beginning of last month:
    • Site-wide: 15,950

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

genomics more details view paper
  • Downloaded 3,247 times
  • Download rankings, all-time:
    • Site-wide: 3,711
    • In genomics: 418
  • Year to date:
    • Site-wide: 60,814
  • Since beginning of last month:
    • Site-wide: 46,293

Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to disease

genetics more details view paper
  • Downloaded 2,319 times
  • Download rankings, all-time:
    • Site-wide: 6,044
    • In genetics: 284
  • Year to date:
    • Site-wide: 37,796
  • Since beginning of last month:
    • Site-wide: 45,973

Biological and clinical insights from genetics of insomnia symptoms

genomics more details view paper
  • Downloaded 1,977 times
  • Download rankings, all-time:
    • Site-wide: 7,624
    • In genomics: 832
  • Year to date:
    • Site-wide: 12,941
  • Since beginning of last month:
    • Site-wide: 14,360

Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

epidemiology more details view paper
  • Downloaded 1,930 times
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    • Site-wide: 7,903
    • In epidemiology: 616
  • Year to date:
    • Site-wide: 104,374
  • Since beginning of last month:
    • Site-wide: 77,218

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

genetics more details view paper
  • Downloaded 1,851 times
  • Download rankings, all-time:
    • Site-wide: 8,430
    • In genetics: 396
  • Year to date:
    • Site-wide: 89,197
  • Since beginning of last month:
    • Site-wide: 91,894

Assessing the pathogenicity, penetrance and expressivity of putative disease-causing variants in a population setting

genetics more details view paper
  • Downloaded 1,830 times
  • Download rankings, all-time:
    • Site-wide: 8,582
    • In genetics: 403
  • Year to date:
    • Site-wide: 62,917
  • Since beginning of last month:
    • Site-wide: 61,533

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

genetics more details view paper
  • Downloaded 1,660 times
  • Download rankings, all-time:
    • Site-wide: 9,916
    • In genetics: 471
  • Year to date:
    • Site-wide: 65,362
  • Since beginning of last month:
    • Site-wide: 46,768

Mosaic Turner syndrome shows reduced phenotypic penetrance in an adult population study compared to clinically ascertained cases

genetics more details view paper
  • Downloaded 1,656 times
  • Download rankings, all-time:
    • Site-wide: 9,954
    • In genetics: 475
  • Year to date:
    • Site-wide: 41,816
  • Since beginning of last month:
    • Site-wide: 46,020

Genome-wide association analyses in >119,000 individuals identifies thirteen morningness and two sleep duration loci

genetics more details view paper
  • Downloaded 1,641 times
  • Download rankings, all-time:
    • Site-wide: 10,081
    • In genetics: 483
  • Year to date:
    • Site-wide: 86,354
  • Since beginning of last month:
    • Site-wide: 107,669

Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

genetics more details view paper
  • Downloaded 1,613 times
  • Download rankings, all-time:
    • Site-wide: 10,331
    • In genetics: 498
  • Year to date:
    • Site-wide: 54,901
  • Since beginning of last month:
    • Site-wide: 47,034

GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

genetics more details view paper
  • Downloaded 1,500 times
  • Download rankings, all-time:
    • Site-wide: 11,447
    • In genetics: 548
  • Year to date:
    • Site-wide: 69,351
  • Since beginning of last month:
    • Site-wide: 64,709

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

genetics more details view paper
  • Downloaded 1,418 times
  • Download rankings, all-time:
    • Site-wide: 12,506
    • In genetics: 614
  • Year to date:
    • Site-wide: 79,041
  • Since beginning of last month:
    • Site-wide: 53,435

Genetic studies of accelerometer-based sleep measures in 85,670 individuals yield new insights into human sleep behaviour

genetics more details view paper
  • Downloaded 1,285 times
  • Download rankings, all-time:
    • Site-wide: 14,540
    • In genetics: 719
  • Year to date:
    • Site-wide: 78,958
  • Since beginning of last month:
    • Site-wide: 77,821

HUMAN LONGEVITY IS INFLUENCED BY MANY GENETIC VARIANTS: EVIDENCE FROM 75,000 UK BIOBANK PARTICIPANTS

genomics more details view paper
  • Downloaded 1,225 times
  • Download rankings, all-time:
    • Site-wide: 15,635
    • In genomics: 1,612
  • Year to date:
    • Site-wide: 113,312
  • Since beginning of last month:
    • Site-wide: 101,564

Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics

genetics more details view paper
  • Downloaded 1,203 times
  • Download rankings, all-time:
    • Site-wide: 16,052
    • In genetics: 793
  • Year to date:
    • Site-wide: 79,488
  • Since beginning of last month:
    • Site-wide: 77,660

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

genetic and genomic medicine more details view paper
  • Downloaded 1,083 times
  • Download rankings, all-time:
    • Site-wide: 18,734
    • In genetic and genomic medicine: 64
  • Year to date:
    • Site-wide: 8,092
  • Since beginning of last month:
    • Site-wide: 10,403

A common allele in FGF21 associated with preference for sugar consumption lowers body fat in the lower body and increases blood pressure

genetics more details view paper
  • Downloaded 950 times
  • Download rankings, all-time:
    • Site-wide: 22,635
    • In genetics: 1,093
  • Year to date:
    • Site-wide: 65,613
  • Since beginning of last month:
    • Site-wide: 59,736

Red Blood Cell Distribution Width: genetic evidence for aging pathways in 116,666 volunteers

genomics more details view paper
  • Downloaded 948 times
  • Download rankings, all-time:
    • Site-wide: 22,719
    • In genomics: 2,222
  • Year to date:
    • Site-wide: 102,097
  • Since beginning of last month:
    • Site-wide: 101,729

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

genetics more details view paper
  • Downloaded 794 times
  • Download rankings, all-time:
    • Site-wide: 29,220
    • In genetics: 1,417
  • Year to date:
    • Site-wide: 14,651
  • Since beginning of last month:
    • Site-wide: 11,687

Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause, and impact reproductive health: a UK Biobank study

genetics more details view paper
  • Downloaded 700 times
  • Download rankings, all-time:
    • Site-wide: 34,784
    • In genetics: 1,670
  • Year to date:
    • Site-wide: 52,188
  • Since beginning of last month:
    • Site-wide: 40,949

Quantifying the extent to which index event biases influence large genetic association studies

genetics more details view paper
  • Downloaded 689 times
  • Download rankings, all-time:
    • Site-wide: 35,555
    • In genetics: 1,701
  • Year to date:
    • Site-wide: 121,877
  • Since beginning of last month:
    • Site-wide: 125,743

Maximum likelihood method quantifies the overall contribution of gene-environment interaction to continuous traits: an application to complex traits in the UK Biobank

epidemiology more details view paper
  • Downloaded 674 times
  • Download rankings, all-time:
    • Site-wide: 36,589
    • In epidemiology: 1,787
  • Year to date:
    • Site-wide: 79,567
  • Since beginning of last month:
    • Site-wide: 94,093

Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

genetics more details view paper
  • Downloaded 669 times
  • Download rankings, all-time:
    • Site-wide: 36,991
    • In genetics: 1,769
  • Year to date:
    • Site-wide: 100,400
  • Since beginning of last month:
    • Site-wide: 91,962

Genetic predictors of participation in optional components of UK Biobank

genetics more details view paper
  • Downloaded 640 times
  • Download rankings, all-time:
    • Site-wide: 39,185
    • In genetics: 1,862
  • Year to date:
    • Site-wide: 45,272
  • Since beginning of last month:
    • Site-wide: 95,949

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

genomics more details view paper
  • Downloaded 630 times
  • Download rankings, all-time:
    • Site-wide: 39,966
    • In genomics: 3,327
  • Year to date:
    • Site-wide: 95,792
  • Since beginning of last month:
    • Site-wide: 91,756

Genetic insights into the biological mechanisms governing human ovarian ageing

sexual and reproductive health more details view paper
  • Downloaded 587 times
  • Download rankings, all-time:
    • Site-wide: 43,697
    • In sexual and reproductive health: 18
  • Year to date:
    • Site-wide: 2,457
  • Since beginning of last month:
    • Site-wide: 8,052

Evidence of a common causal relationship between body mass index and inflammatory skin disease: a Mendelian Randomization study

genetics more details view paper
  • Downloaded 579 times
  • Download rankings, all-time:
    • Site-wide: 44,395
    • In genetics: 2,079
  • Year to date:
    • Site-wide: 104,178
  • Since beginning of last month:
    • Site-wide: 101,289

Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

epidemiology more details view paper
  • Downloaded 579 times
  • Download rankings, all-time:
    • Site-wide: 44,398
    • In epidemiology: 2,083
  • Year to date:
    • Site-wide: 95,627
  • Since beginning of last month:
    • Site-wide: 76,486

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

genetics more details view paper
  • Downloaded 574 times
  • Download rankings, all-time:
    • Site-wide: 44,865
    • In genetics: 2,099
  • Year to date:
    • Site-wide: 113,244
  • Since beginning of last month:
    • Site-wide: 86,258

Genome-wide association analysis of excessive daytime sleepiness identifies 42 loci that suggest phenotypic subgroups

genomics more details view paper
  • Downloaded 572 times
  • Download rankings, all-time:
    • Site-wide: 44,999
    • In genomics: 3,617
  • Year to date:
    • Site-wide: 92,132
  • Since beginning of last month:
    • Site-wide: 83,933

Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes respectively

genetics more details view paper
  • Downloaded 507 times
  • Download rankings, all-time:
    • Site-wide: 52,152
    • In genetics: 2,429
  • Year to date:
    • Site-wide: 107,463
  • Since beginning of last month:
    • Site-wide: 124,362

Effects of body mass index on relationship status, social contact, and socioeconomic position: Mendelian Randomization study in UK Biobank

epidemiology more details view paper
  • Downloaded 445 times
  • Download rankings, all-time:
    • Site-wide: 60,162
    • In epidemiology: 2,605
  • Year to date:
    • Site-wide: 131,794
  • Since beginning of last month:
    • Site-wide: 127,552

Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

epidemiology more details view paper
  • Downloaded 357 times
  • Download rankings, all-time:
    • Site-wide: 74,216
    • In epidemiology: 3,121
  • Year to date:
    • Site-wide: 39,953
  • Since beginning of last month:
    • Site-wide: 34,876

A genome wide association study of frozen shoulder identifies a common variant of WNT7B and diabetes as causal risk factors

orthopedics more details view paper
  • Downloaded 299 times
  • Download rankings, all-time:
    • Site-wide: 85,658
    • In orthopedics: 26
  • Year to date:
    • Site-wide: 10,743
  • Since beginning of last month:
    • Site-wide: 11,527

Higher maternal adiposity reduces offspring birth weight if associated with a metabolically favourable profile

genetic and genomic medicine more details view paper
  • Downloaded 191 times
  • Download rankings, all-time:
    • Site-wide: 109,540
    • In genetic and genomic medicine: 478
  • Year to date:
    • Site-wide: 94,975
  • Since beginning of last month:
    • Site-wide: 74,065

Assessing the causal role of sleep traits on glycated haemoglobin: a Mendelian randomization study

epidemiology more details view paper
  • Downloaded 138 times
  • Download rankings, all-time:
    • Site-wide: 120,571
    • In epidemiology: 4,932
  • Year to date:
    • Site-wide: 27,646
  • Since beginning of last month:
    • Site-wide: 34,918

Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight

genetics more details view paper
  • Downloaded 132 times
  • Download rankings, all-time:
    • Site-wide: 121,849
    • In genetics: 5,169
  • Year to date:
    • Site-wide: 105,617
  • Since beginning of last month:
    • Site-wide: 119,499

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