Author: Timothy M. Frayling

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Preprints

Genetic Consequences of Social Stratification in Great Britain

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  • Site-wide: 1,117
  • In genetics: 35
• Year to date:
  • Site-wide: 10,089
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  • Site-wide: 10,090

Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry

• Downloaded 6,620 times
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  • Site-wide: 1,354
  • In genetics: 46
• Year to date:
  • Site-wide: 18,902
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  • Site-wide: 15,950

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

• Downloaded 3,247 times
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  • Site-wide: 3,711
  • In genomics: 418
• Year to date:
  • Site-wide: 60,814
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  • Site-wide: 46,293

Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to disease

• Downloaded 2,319 times
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  • Site-wide: 6,044
  • In genetics: 284
• Year to date:
  • Site-wide: 37,796
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  • Site-wide: 45,973

Biological and clinical insights from genetics of insomnia symptoms

• Downloaded 1,977 times
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  • Site-wide: 7,624
  • In genomics: 832
• Year to date:
  • Site-wide: 12,941
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  • Site-wide: 14,360

Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

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  • Site-wide: 7,903
  • In epidemiology: 616
• Year to date:
  • Site-wide: 104,374
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  • Site-wide: 77,218

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,851 times
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  • Site-wide: 8,430
  • In genetics: 396
• Year to date:
  • Site-wide: 89,197
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  • Site-wide: 91,894

Assessing the pathogenicity, penetrance and expressivity of putative disease-causing variants in a population setting

• Downloaded 1,830 times
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  • Site-wide: 8,582
  • In genetics: 403
• Year to date:
  • Site-wide: 62,917
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  • Site-wide: 61,533

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,660 times
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  • Site-wide: 9,916
  • In genetics: 471
• Year to date:
  • Site-wide: 65,362
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  • Site-wide: 46,768

Mosaic Turner syndrome shows reduced phenotypic penetrance in an adult population study compared to clinically ascertained cases

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  • Site-wide: 9,954
  • In genetics: 475
• Year to date:
  • Site-wide: 41,816
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  • Site-wide: 46,020

Genome-wide association analyses in >119,000 individuals identifies thirteen morningness and two sleep duration loci

• Downloaded 1,641 times
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  • Site-wide: 10,081
  • In genetics: 483
• Year to date:
  • Site-wide: 86,354
• Since beginning of last month:
  • Site-wide: 107,669

Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

• Downloaded 1,613 times
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  • Site-wide: 10,331
  • In genetics: 498
• Year to date:
  • Site-wide: 54,901
• Since beginning of last month:
  • Site-wide: 47,034

GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

• Downloaded 1,500 times
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  • Site-wide: 11,447
  • In genetics: 548
• Year to date:
  • Site-wide: 69,351
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  • Site-wide: 64,709

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

• Downloaded 1,418 times
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  • Site-wide: 12,506
  • In genetics: 614
• Year to date:
  • Site-wide: 79,041
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  • Site-wide: 53,435

Genetic studies of accelerometer-based sleep measures in 85,670 individuals yield new insights into human sleep behaviour

• Downloaded 1,285 times
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  • Site-wide: 14,540
  • In genetics: 719
• Year to date:
  • Site-wide: 78,958
• Since beginning of last month:
  • Site-wide: 77,821

HUMAN LONGEVITY IS INFLUENCED BY MANY GENETIC VARIANTS: EVIDENCE FROM 75,000 UK BIOBANK PARTICIPANTS

• Downloaded 1,225 times
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  • Site-wide: 15,635
  • In genomics: 1,612
• Year to date:
  • Site-wide: 113,312
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  • Site-wide: 101,564

Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics

• Downloaded 1,203 times
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  • Site-wide: 16,052
  • In genetics: 793
• Year to date:
  • Site-wide: 79,488
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  • Site-wide: 77,660

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 1,083 times
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  • Site-wide: 18,734
  • In genetic and genomic medicine: 64
• Year to date:
  • Site-wide: 8,092
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  • Site-wide: 10,403

A common allele in FGF21 associated with preference for sugar consumption lowers body fat in the lower body and increases blood pressure

• Downloaded 950 times
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  • Site-wide: 22,635
  • In genetics: 1,093
• Year to date:
  • Site-wide: 65,613
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  • Site-wide: 59,736

Red Blood Cell Distribution Width: genetic evidence for aging pathways in 116,666 volunteers

• Downloaded 948 times
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  • Site-wide: 22,719
  • In genomics: 2,222
• Year to date:
  • Site-wide: 102,097
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  • Site-wide: 101,729

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 794 times
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  • Site-wide: 29,220
  • In genetics: 1,417
• Year to date:
  • Site-wide: 14,651
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  • Site-wide: 11,687

Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause, and impact reproductive health: a UK Biobank study

• Downloaded 700 times
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  • Site-wide: 34,784
  • In genetics: 1,670
• Year to date:
  • Site-wide: 52,188
• Since beginning of last month:
  • Site-wide: 40,949

Quantifying the extent to which index event biases influence large genetic association studies

• Downloaded 689 times
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  • Site-wide: 35,555
  • In genetics: 1,701
• Year to date:
  • Site-wide: 121,877
• Since beginning of last month:
  • Site-wide: 125,743

Maximum likelihood method quantifies the overall contribution of gene-environment interaction to continuous traits: an application to complex traits in the UK Biobank

• Downloaded 674 times
• Download rankings, all-time:
  • Site-wide: 36,589
  • In epidemiology: 1,787
• Year to date:
  • Site-wide: 79,567
• Since beginning of last month:
  • Site-wide: 94,093

Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

• Downloaded 669 times
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  • Site-wide: 36,991
  • In genetics: 1,769
• Year to date:
  • Site-wide: 100,400
• Since beginning of last month:
  • Site-wide: 91,962

Genetic predictors of participation in optional components of UK Biobank

• Downloaded 640 times
• Download rankings, all-time:
  • Site-wide: 39,185
  • In genetics: 1,862
• Year to date:
  • Site-wide: 45,272
• Since beginning of last month:
  • Site-wide: 95,949

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

• Downloaded 630 times
• Download rankings, all-time:
  • Site-wide: 39,966
  • In genomics: 3,327
• Year to date:
  • Site-wide: 95,792
• Since beginning of last month:
  • Site-wide: 91,756

Genetic insights into the biological mechanisms governing human ovarian ageing

• Downloaded 587 times
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  • Site-wide: 43,697
  • In sexual and reproductive health: 18
• Year to date:
  • Site-wide: 2,457
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  • Site-wide: 8,052

Evidence of a common causal relationship between body mass index and inflammatory skin disease: a Mendelian Randomization study

• Downloaded 579 times
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  • Site-wide: 44,395
  • In genetics: 2,079
• Year to date:
  • Site-wide: 104,178
• Since beginning of last month:
  • Site-wide: 101,289

Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

• Downloaded 579 times
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  • Site-wide: 44,398
  • In epidemiology: 2,083
• Year to date:
  • Site-wide: 95,627
• Since beginning of last month:
  • Site-wide: 76,486

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

• Downloaded 574 times
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  • Site-wide: 44,865
  • In genetics: 2,099
• Year to date:
  • Site-wide: 113,244
• Since beginning of last month:
  • Site-wide: 86,258

Genome-wide association analysis of excessive daytime sleepiness identifies 42 loci that suggest phenotypic subgroups

• Downloaded 572 times
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  • Site-wide: 44,999
  • In genomics: 3,617
• Year to date:
  • Site-wide: 92,132
• Since beginning of last month:
  • Site-wide: 83,933

Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes respectively

• Downloaded 507 times
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  • Site-wide: 52,152
  • In genetics: 2,429
• Year to date:
  • Site-wide: 107,463
• Since beginning of last month:
  • Site-wide: 124,362

Effects of body mass index on relationship status, social contact, and socioeconomic position: Mendelian Randomization study in UK Biobank

• Downloaded 445 times
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  • Site-wide: 60,162
  • In epidemiology: 2,605
• Year to date:
  • Site-wide: 131,794
• Since beginning of last month:
  • Site-wide: 127,552

Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

• Downloaded 357 times
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  • Site-wide: 74,216
  • In epidemiology: 3,121
• Year to date:
  • Site-wide: 39,953
• Since beginning of last month:
  • Site-wide: 34,876

A genome wide association study of frozen shoulder identifies a common variant of WNT7B and diabetes as causal risk factors

• Downloaded 299 times
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  • Site-wide: 85,658
  • In orthopedics: 26
• Year to date:
  • Site-wide: 10,743
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  • Site-wide: 11,527

Higher maternal adiposity reduces offspring birth weight if associated with a metabolically favourable profile

• Downloaded 191 times
• Download rankings, all-time:
  • Site-wide: 109,540
  • In genetic and genomic medicine: 478
• Year to date:
  • Site-wide: 94,975
• Since beginning of last month:
  • Site-wide: 74,065

Assessing the causal role of sleep traits on glycated haemoglobin: a Mendelian randomization study

• Downloaded 138 times
• Download rankings, all-time:
  • Site-wide: 120,571
  • In epidemiology: 4,932
• Year to date:
  • Site-wide: 27,646
• Since beginning of last month:
  • Site-wide: 34,918

Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight

• Downloaded 132 times
• Download rankings, all-time:
  • Site-wide: 121,849
  • In genetics: 5,169
• Year to date:
  • Site-wide: 105,617
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  • Site-wide: 119,499