Author: Roel A Ophoff

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Preprints

The genetic architecture of the human cerebral cortex

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Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 1,070
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Transcriptome analysis in whole blood reveals increased microbial diversity in schizophrenia

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Comprehensive analysis of RNA-sequencing to find the source of 1 trillion reads across diverse adult human tissues

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  • Site-wide: 4,143
  • In genomics: 492
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  • Site-wide: 59,259

Genome-wide association study identifies 48 common genetic variants associated with handedness

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Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

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  • Site-wide: 5,081
  • In genetic and genomic medicine: 12
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A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 7,923
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Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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  • Site-wide: 8,390
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Whole Genome Sequencing in Psychiatric Disorders: the WGSPD Consortium

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Dynamics of Brain Structure and its Genetic Architecture over the Lifespan

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  • Site-wide: 4,080
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Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 68,194
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  • Site-wide: 105,148

Genome-wide association study of over 40,000 bipolar disorder cases provides novel biological insights

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  • Site-wide: 12,215
  • In psychiatry and clinical psychology: 35
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  • Site-wide: 3,980
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  • Site-wide: 2,527

Complement component 4 genes contribute sex-specific vulnerability in diverse illnesses

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  • Site-wide: 76,753
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  • Site-wide: 46,075

Shared vulnerability for connectome alterations across psychiatric and neurological brain disorders

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  • Site-wide: 21,835
  • In neuroscience: 2,906
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  • Site-wide: 48,444
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  • Site-wide: 41,281

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

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  • Site-wide: 24,811
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  • Site-wide: 85,040
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Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

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  • Site-wide: 26,028
  • In genomics: 2,486
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A longitudinal model of human neuronal differentiation for functional investigation of schizophrenia polygenic risk

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  • Site-wide: 28,180
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  • Site-wide: 86,530

Planar cell polarity pathway and development of the human visual cortex

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  • Site-wide: 28,661
  • In neuroscience: 3,985
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Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

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  • Site-wide: 31,414
  • In genetics: 1,581
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  • Site-wide: 57,865
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  • Site-wide: 103,976

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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  • Site-wide: 32,311
  • In genetics: 1,621
• Year to date:
  • Site-wide: 9,536
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  • Site-wide: 9,971

Integrative analysis of Dupuytren's disease identifies novel risk locus and reveals a shared genetic etiology with BMI

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  • Site-wide: 34,748
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  • Site-wide: 106,826

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis.

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  • Site-wide: 42,262
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Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates

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  • Site-wide: 43,164
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  • Site-wide: 108,862

Whole blood transcriptome analysis in bipolar disorder reveals strong lithium effect

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  • Site-wide: 46,420
  • In genomics: 3,756
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  • Site-wide: 39,818

Structural brain alterations in youth with psychosis and bipolar spectrum symptoms

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  • Site-wide: 51,808
  • In neuroscience: 7,846
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  • Site-wide: 58,834
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  • Site-wide: 40,874

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

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  • Site-wide: 71,009
  • In genetic and genomic medicine: 196
• Year to date:
  • Site-wide: 10,012
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  • Site-wide: 1,163

Genetic and clinical analyses of psychosis spectrum symptoms in a large multi-ethnic youth cohort reveal significant link with ADHD.

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  • Site-wide: 81,112
  • In genetics: 3,788
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  • Site-wide: 90,059
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  • Site-wide: 40,417

Transient patterns of functional dysconnectivity in youth with psychosis spectrum symptoms

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  • Site-wide: 95,063
  • In neuroscience: 15,011
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  • Site-wide: 121,413
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  • Site-wide: 91,183

Gene expression imputation provides insight into the genetic architecture of frontotemporal dementia

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  • Site-wide: 96,155
  • In genetics: 4,410
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  • Site-wide: 42,688
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  • Site-wide: 57,552

Accelerated aging in the brain, epigenetic aging in blood, and polygenic risk for schizophrenia

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  • Site-wide: 102,191
  • In psychiatry and clinical psychology: 376
• Year to date:
  • Site-wide: 24,426
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  • Site-wide: 30,642