Author: James S. Fraser
- ORCiD: http://orcid.org/0000-0002-5080-2859
- Most recently observed institution: University of California San Francisco
Rankings
- All-time downloads: 224,326 (rank: 454 )
- Categories:
- biochemistry: 8,729 (rank: 334 )
- bioengineering: 1,915 (rank: 2,272 (tie) )
- bioinformatics: 638 (rank: 27,261 (tie) )
- biophysics: 24,631 (rank: 28 )
- cancer biology: 1,455 (rank: 7,435 (tie) )
- immunology: 480 (rank: 27,433 (tie) )
- synthetic biology: 3,840 (rank: 437 (tie) )
- systems biology: 179,786 (rank: 15 )
Downloads per author, site-wide
Preprints
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing
systems biology more details view paper- Downloaded 179,611 times
- Download rankings, all-time:
- Site-wide: 31
- In systems biology: 1
- Year to date:
- Site-wide: 994
- Since beginning of last month:
- Site-wide: 774
Deep neural language modeling enables functional protein generation across families
synthetic biology more details view paper- Downloaded 4,482 times
- Download rankings, all-time:
- Site-wide: 3,605
- In synthetic biology: 37
- Year to date:
- Site-wide: 1,075
- Since beginning of last month:
- Site-wide: 788
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
biophysics more details view paper- Downloaded 3,317 times
- Download rankings, all-time:
- Site-wide: 5,504
- In biophysics: 89
- Year to date:
- Site-wide: 4,624
- Since beginning of last month:
- Site-wide: 5,346
A multi-model approach to assessing local and global cryo-EM map quality
biophysics more details view paper- Downloaded 2,110 times
- Download rankings, all-time:
- Site-wide: 10,638
- In biophysics: 197
- Year to date:
- Site-wide: 101,236
- Since beginning of last month:
- Site-wide: 68,516
Mapping the Conformational Landscape of a Dynamic Enzyme by XFEL and Multitemperature Crystallography
biophysics more details view paper- Downloaded 1,834 times
- Download rankings, all-time:
- Site-wide: 13,116
- In biophysics: 275
- Year to date:
- Site-wide: 72,495
- Since beginning of last month:
- Site-wide: 119,565
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking
biochemistry more details view paper- Downloaded 1,821 times
- Download rankings, all-time:
- Site-wide: 13,254
- In biochemistry: 266
- Year to date:
- Site-wide: 37,328
- Since beginning of last month:
- Site-wide: 31,768
Co-occurring alterations in the RAS-MAPK pathway limit response to MET inhibitor treatment in MET exon 14 skipping mutation positive lung cancer
cancer biology more details view paper- Downloaded 1,469 times
- Download rankings, all-time:
- Site-wide: 18,298
- In cancer biology: 378
- Year to date:
- Site-wide: 93,876
- Since beginning of last month:
- Site-wide: 94,261
Automated structure refinement of macromolecular assemblies from cryo-EM maps using Rosetta
biochemistry more details view paper- Downloaded 1,290 times
- Download rankings, all-time:
- Site-wide: 22,357
- In biochemistry: 456
- Year to date:
- Site-wide: 131,094
- Since beginning of last month:
- Site-wide: 136,912
Computational design of a modular protein sense/response system
biophysics more details view paper- Downloaded 1,238 times
- Download rankings, all-time:
- Site-wide: 23,897
- In biophysics: 581
- Year to date:
- Site-wide: 132,291
- Since beginning of last month:
- Site-wide: 133,451
qFit-ligand reveals widespread conformational heterogeneity of drug-like molecules in X-ray electron density maps
biophysics more details view paper- Downloaded 1,232 times
- Download rankings, all-time:
- Site-wide: 24,056
- In biophysics: 594
- Year to date:
- Site-wide: 142,165
- Since beginning of last month:
- Site-wide: 84,014
Mix-and-inject XFEL crystallography reveals gated conformational dynamics during enzyme catalysis
biochemistry more details view paper- Downloaded 1,208 times
- Download rankings, all-time:
- Site-wide: 24,803
- In biochemistry: 535
- Year to date:
- Site-wide: 72,488
- Since beginning of last month:
- Site-wide: 75,438
Temperature-Jump Solution X-ray Scattering Reveals Distinct Motions in a Dynamic Enzyme
biophysics more details view paper- Downloaded 1,206 times
- Download rankings, all-time:
- Site-wide: 24,855
- In biophysics: 620
- Year to date:
- Site-wide: 105,547
- Since beginning of last month:
- Site-wide: 106,719
Effects of α-tubulin acetylation on microtubule structure and stability
biophysics more details view paper- Downloaded 1,151 times
- Download rankings, all-time:
- Site-wide: 26,676
- In biophysics: 686
- Year to date:
- Site-wide: 118,721
- Since beginning of last month:
- Site-wide: 108,610
High-resolution cryo-electron microscopy structure of the Escherichia coli 50S subunit and validation of nucleotide modifications
biochemistry more details view paper- Downloaded 1,136 times
- Download rankings, all-time:
- Site-wide: 27,247
- In biochemistry: 605
- Year to date:
- Site-wide: 56,409
- Since beginning of last month:
- Site-wide: 34,974
Measuring and modeling diffuse scattering in protein X-ray crystallography
biophysics more details view paper- Downloaded 1,119 times
- Download rankings, all-time:
- Site-wide: 27,893
- In biophysics: 726
- Year to date:
- Site-wide: 156,496
- Since beginning of last month:
- Site-wide: 119,023
Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals
biophysics more details view paper- Downloaded 1,092 times
- Download rankings, all-time:
- Site-wide: 28,913
- In biophysics: 771
- Year to date:
- Site-wide: 135,905
- Since beginning of last month:
- Site-wide: 109,258
Side-chain-directed model and map validation for 3D Electron Cryomicroscopy
biophysics more details view paper- Downloaded 1,056 times
- Download rankings, all-time:
- Site-wide: 30,342
- In biophysics: 831
- Year to date:
- Site-wide: 120,176
- Since beginning of last month:
- Site-wide: 68,625
Expanding the space of protein geometries by computational design of de novo fold families
bioengineering more details view paper- Downloaded 1,042 times
- Download rankings, all-time:
- Site-wide: 30,918
- In bioengineering: 528
- Year to date:
- Site-wide: 146,085
- Since beginning of last month:
- Site-wide: 155,522
Outcomes of the 2019 EMDataResource model challenge: validation of cryo-EM models at near-atomic resolution
biochemistry more details view paper- Downloaded 988 times
- Download rankings, all-time:
- Site-wide: 33,501
- In biochemistry: 770
- Year to date:
- Site-wide: 92,353
- Since beginning of last month:
- Site-wide: 79,656
Accurately positioning functional residues with robotics-inspired computational protein design
bioengineering more details view paper- Downloaded 962 times
- Download rankings, all-time:
- Site-wide: 34,886
- In bioengineering: 702
- Year to date:
- Site-wide: 23,233
- Since beginning of last month:
- Site-wide: 29,057
New routes for PTP1B allosteric inhibition by multitemperature crystallography, fragment screening and covalent tethering
biophysics more details view paper- Downloaded 959 times
- Download rankings, all-time:
- Site-wide: 35,049
- In biophysics: 1,027
- Year to date:
- Site-wide: 60,442
- Since beginning of last month:
- Site-wide: 146,988
Determination of Ubiquitin Fitness Landscapes Under Different Chemical Stresses in a Classroom Setting
systems biology more details view paper- Downloaded 955 times
- Download rankings, all-time:
- Site-wide: 35,221
- In systems biology: 659
- Year to date:
- Site-wide: 131,657
- Since beginning of last month:
- Site-wide: 149,639
Evolution of an enzyme conformational ensemble guides design of an efficient biocatalyst
biophysics more details view paper- Downloaded 829 times
- Download rankings, all-time:
- Site-wide: 43,387
- In biophysics: 1,335
- Year to date:
- Site-wide: 95,025
- Since beginning of last month:
- Site-wide: 52,795
Exposing hidden alternative backbone conformations in X-ray crystallography using qFit
biophysics more details view paper- Downloaded 822 times
- Download rankings, all-time:
- Site-wide: 43,910
- In biophysics: 1,301
- Year to date:
- Site-wide: 154,996
- Since beginning of last month:
- Site-wide: 163,303
Assessment of enzyme active site positioning and tests of catalytic mechanisms through X-ray-derived conformational ensembles
biophysics more details view paper- Downloaded 806 times
- Download rankings, all-time:
- Site-wide: 45,178
- In biophysics: 1,341
- Year to date:
- Site-wide: 161,946
- Since beginning of last month:
- Site-wide: 178,522
Predicting X-ray Diffuse Scattering from Translation Libration Screw Structural Ensembles
biophysics more details view paper- Downloaded 800 times
- Download rankings, all-time:
- Site-wide: 45,636
- In biophysics: 1,375
- Year to date:
- Site-wide: 169,324
- Since beginning of last month:
- Site-wide: 131,986
Flexibility and design: conformational heterogeneity along the evolutionary trajectory of a redesigned ubiquitin
biophysics more details view paper- Downloaded 788 times
- Download rankings, all-time:
- Site-wide: 46,657
- In biophysics: 1,435
- Year to date:
- Site-wide: 143,105
- Since beginning of last month:
- Site-wide: 108,194
Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance
biochemistry more details view paper- Downloaded 786 times
- Download rankings, all-time:
- Site-wide: 46,861
- In biochemistry: 1,220
- Year to date:
- Site-wide: 40,565
- Since beginning of last month:
- Site-wide: 29,274
Bringing Diffuse X-ray Scattering Into Focus
biophysics more details view paper- Downloaded 734 times
- Download rankings, all-time:
- Site-wide: 51,606
- In biophysics: 1,610
- Year to date:
- Site-wide: 137,184
- Since beginning of last month:
- Site-wide: 131,928
Rescue of Conformational Dynamics in Enzyme Catalysis by Directed Evolution
biophysics more details view paper- Downloaded 723 times
- Download rankings, all-time:
- Site-wide: 52,789
- In biophysics: 1,631
- Year to date:
- Site-wide: 156,732
- Since beginning of last month:
- Site-wide: 150,916
A counter-enzyme complex regulates glutamate metabolism in Bacillus subtilis
biochemistry more details view paper- Downloaded 721 times
- Download rankings, all-time:
- Site-wide: 52,937
- In biochemistry: 1,427
- Year to date:
- Site-wide: 34,359
- Since beginning of last month:
- Site-wide: 30,424
Model selection for biological crystallography
biophysics more details view paper- Downloaded 711 times
- Download rankings, all-time:
- Site-wide: 54,035
- In biophysics: 1,704
- Year to date:
- Site-wide: 132,296
- Since beginning of last month:
- Site-wide: 105,221
Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics
biophysics more details view paper- Downloaded 701 times
- Download rankings, all-time:
- Site-wide: 55,098
- In biophysics: 1,826
- Year to date:
- Site-wide: 12,129
- Since beginning of last month:
- Site-wide: 51,415
Ligand binding remodels protein side chain conformational heterogeneity
biophysics more details view paper- Downloaded 661 times
- Download rankings, all-time:
- Site-wide: 59,783
- In biophysics: 2,112
- Year to date:
- Site-wide: 30,068
- Since beginning of last month:
- Site-wide: 60,673
Extending Chemical Perturbations Of The Ubiquitin Fitness Landscape In A Classroom Setting
bioinformatics more details view paper- Downloaded 645 times
- Download rankings, all-time:
- Site-wide: 61,680
- In bioinformatics: 5,725
- Year to date:
- Site-wide: 157,096
- Since beginning of last month:
- Site-wide: 162,930
Differences in the chitinolytic activity of mammalian chitinases on soluble and crystalline substrates
biochemistry more details view paper- Downloaded 562 times
- Download rankings, all-time:
- Site-wide: 73,383
- In biochemistry: 1,923
- Year to date:
- Site-wide: 88,096
- Since beginning of last month:
- Site-wide: 98,188
qFit 3: Protein and ligand multiconformer modeling for X-ray crystallographic and single-particle cryo-EM density maps
biophysics more details view paper- Downloaded 543 times
- Download rankings, all-time:
- Site-wide: 76,487
- In biophysics: 2,872
- Year to date:
- Site-wide: 54,863
- Since beginning of last month:
- Site-wide: 37,711
Type 2 innate immunity regulates hair follicle homeostasis to control Demodex pathosymbionts
immunology more details view paper- Downloaded 505 times
- Download rankings, all-time:
- Site-wide: 83,376
- In immunology: 2,565
- Year to date:
- Site-wide: 54,447
- Since beginning of last month:
- Site-wide: 58,798
The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and X-ray diffraction at room temperature
biochemistry more details view paper- Downloaded 485 times
- Download rankings, all-time:
- Site-wide: 87,324
- In biochemistry: 3,243
- Year to date:
- Site-wide: 3,975
- Since beginning of last month:
- Site-wide: 12,583
From deep TLS validation to ensembles of atomic models built from elemental motions
biophysics more details view paper- Downloaded 460 times
- Download rankings, all-time:
- Site-wide: 92,357
- In biophysics: 3,176
- Year to date:
- Site-wide: 169,325
- Since beginning of last month:
- Site-wide: 183,898
Liquid-like and rigid-body motions in molecular-dynamics simulations of a crystalline protein
biophysics more details view paper- Downloaded 361 times
- Download rankings, all-time:
- Site-wide: 116,289
- In biophysics: 4,306
- Year to date:
- Site-wide: 135,262
- Since beginning of last month:
- Site-wide: 122,129
Molecular-Dynamics Simulation Methods for Macromolecular Crystallography
biophysics more details view paper- Downloaded 273 times
- Download rankings, all-time:
- Site-wide: 141,376
- In biophysics: None
- Year to date:
- Site-wide: 9,169
- Since beginning of last month:
- Site-wide: 1,589
Ensemble-function relationships to evaluate catalysis in the ketosteroid isomerase oxyanion hole
biochemistry more details view paper- Downloaded 132 times
- Download rankings, all-time:
- Site-wide: 177,406
- In biochemistry: 5,299
- Year to date:
- Site-wide: 57,765
- Since beginning of last month:
- Site-wide: 59,803
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