Author: Matthias Schlesner

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Preprints

The evolutionary history of 2,658 cancers

• Downloaded 9,487 times
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  • Site-wide: 860
  • In cancer biology: 8
• Year to date:
  • Site-wide: 28,849
• Since beginning of last month:
  • Site-wide: 26,387

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

• Downloaded 5,910 times
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  • Site-wide: 1,580
  • In cancer biology: 20
• Year to date:
  • Site-wide: 2,870
• Since beginning of last month:
  • Site-wide: 2,200

Germline determinants of the somatic mutation landscape in 2,642 cancer genomes

• Downloaded 5,336 times
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  • Site-wide: 1,825
  • In genomics: 177
• Year to date:
  • Site-wide: 20,694
• Since beginning of last month:
  • Site-wide: 26,502

Computational Pan-Genomics: Status, Promises and Challenges

• Downloaded 4,632 times
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  • Site-wide: 2,216
  • In genomics: 240
• Year to date:
  • Site-wide: 27,016
• Since beginning of last month:
  • Site-wide: 35,613

A Comprehensive Assessment of Somatic Mutation Calling in Cancer Genomes

• Downloaded 2,409 times
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  • Site-wide: 5,693
  • In genomics: 647
• Year to date:
  • Site-wide: 96,143
• Since beginning of last month:
  • Site-wide: 91,155

Large-Scale Uniform Analysis of Cancer Whole Genomes in Multiple Computing Environments

• Downloaded 2,338 times
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  • Site-wide: 5,955
  • In genomics: 670
• Year to date:
  • Site-wide: 34,631
• Since beginning of last month:
  • Site-wide: 42,267

Cell segmentation-free inference of cell types from in situ transcriptomics data

• Downloaded 2,178 times
• Download rankings, all-time:
  • Site-wide: 6,586
  • In bioinformatics: 773
• Year to date:
  • Site-wide: 5,492
• Since beginning of last month:
  • Site-wide: 10,289

A comprehensive multicenter comparison of whole genome sequencing pipelines using a uniform tumor-normal sample pair

• Downloaded 2,163 times
• Download rankings, all-time:
  • Site-wide: 6,660
  • In genomics: 740
• Year to date:
  • Site-wide: 80,325
• Since beginning of last month:
  • Site-wide: 56,997

pheno-seq - linking morphological features to gene expression in 3D cell culture systems

• Downloaded 1,828 times
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  • Site-wide: 8,570
  • In genomics: 929
• Year to date:
  • Site-wide: 55,244
• Since beginning of last month:
  • Site-wide: 54,700

Deciphering programs of transcriptional regulation by combined deconvolution of multiple omics layers

• Downloaded 1,650 times
• Download rankings, all-time:
  • Site-wide: 9,987
  • In genomics: 1,084
• Year to date:
  • Site-wide: 69,923
• Since beginning of last month:
  • Site-wide: 86,560

Questioning unexpected CRISPR off-target mutations in vivo

• Downloaded 1,485 times
• Download rankings, all-time:
  • Site-wide: 11,602
  • In genomics: 1,265
• Year to date:
  • Site-wide: 103,743
• Since beginning of last month:
  • Site-wide: 87,041

Genomic footprints of activated telomere maintenance mechanisms in cancer

• Downloaded 1,464 times
• Download rankings, all-time:
  • Site-wide: 11,861
  • In genomics: 1,290
• Year to date:
  • Site-wide: 94,047
• Since beginning of last month:
  • Site-wide: 81,314

ACEseq - allele specific copy number estimation from whole genome sequencing

• Downloaded 1,367 times
• Download rankings, all-time:
  • Site-wide: 13,184
  • In bioinformatics: 1,601
• Year to date:
  • Site-wide: 36,123
• Since beginning of last month:
  • Site-wide: 23,550

Dissecting intratumor heterogeneity of nodal B cell lymphomas on the transcriptional, genetic, and drug response level

• Downloaded 1,093 times
• Download rankings, all-time:
  • Site-wide: 18,437
  • In cancer biology: 428
• Year to date:
  • Site-wide: 13,730
• Since beginning of last month:
  • Site-wide: 12,851

Framework For Quality Assessment Of Whole Genome, Cancer Sequences

• Downloaded 1,078 times
• Download rankings, all-time:
  • Site-wide: 18,837
  • In genomics: 1,905
• Year to date:
  • Site-wide: 126,773
• Since beginning of last month:
  • Site-wide: 110,849

Resolving Drug Effects In Patient-Derived Cancer Cells Links Organoid Responses To Genome Alterations

• Downloaded 948 times
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  • Site-wide: 22,652
  • In cancer biology: 551
• Year to date:
  • Site-wide: 107,296
• Since beginning of last month:
  • Site-wide: 96,301

Identification and prioritisation of causal variants in human genetic disorders from exome or whole genome sequencing data

• Downloaded 725 times
• Download rankings, all-time:
  • Site-wide: 33,114
  • In bioinformatics: 3,716
• Year to date:
  • Site-wide: 103,899
• Since beginning of last month:
  • Site-wide: 113,306

Globally altered epigenetic landscape and lagging osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone

• Downloaded 444 times
• Download rankings, all-time:
  • Site-wide: 60,137
  • In oncology: 76
• Year to date:
  • Site-wide: 97,409
• Since beginning of last month:
  • Site-wide: 84,876

HTSlib-js: Developer toolkit for a client-side JavaScript interface for HTSlib

• Downloaded 380 times
• Download rankings, all-time:
  • Site-wide: 70,035
  • In bioinformatics: 6,689
• Year to date:
  • Site-wide: 102,830
• Since beginning of last month:
  • Site-wide: 98,249

Reprogramming of stromal fibroblasts by chemotherapy-induced secretion of IFNβ1 drives re-growth of breast cancer cells after treatment.

• Downloaded 225 times
• Download rankings, all-time:
  • Site-wide: 101,548
  • In cancer biology: 3,082
• Year to date:
  • Site-wide: 69,445
• Since beginning of last month:
  • Site-wide: 45,701