Author: Matthias Schlesner

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Preprints

The evolutionary history of 2,658 cancers

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  • In cancer biology: 8 out of 3,613
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Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

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  • In cancer biology: 22 out of 3,613
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  • Site-wide: 3,487 out of 100,856

Germline determinants of the somatic mutation landscape in 2,642 cancer genomes

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  • In genomics: 165 out of 6,254
• Year to date:
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  • Site-wide: 11,246 out of 100,856

Computational Pan-Genomics: Status, Promises and Challenges

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  • In genomics: 216 out of 6,254
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  • Site-wide: 10,206 out of 100,856

A Comprehensive Assessment of Somatic Mutation Calling in Cancer Genomes

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  • In genomics: 582 out of 6,254
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  • Site-wide: 66,453 out of 100,856

Large-Scale Uniform Analysis of Cancer Whole Genomes in Multiple Computing Environments

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  • In genomics: 627 out of 6,254
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  • Site-wide: 28,168 out of 100,856

A comprehensive multicenter comparison of whole genome sequencing pipelines using a uniform tumor-normal sample pair

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  • In genomics: 668 out of 6,254
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  • Site-wide: 37,081 out of 100,856

pheno-seq - linking morphological features to gene expression in 3D cell culture systems

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  • In genomics: 844 out of 6,254
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  • Site-wide: 32,613 out of 100,856

Segmentation-free inference of cell-types from in situ transcriptomics data

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  • Site-wide: 5,803 out of 100,856
  • In bioinformatics: 1,019 out of 9,260
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  • Site-wide: 6,646 out of 100,856

Deciphering programs of transcriptional regulation by combined deconvolution of multiple omics layers

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  • In genomics: 994 out of 6,254
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  • Site-wide: 28,078 out of 100,856

Questioning unexpected CRISPR off-target mutations in vivo

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  • In genomics: 1,107 out of 6,254
• Year to date:
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  • Site-wide: 64,850 out of 100,856

Genomic footprints of activated telomere maintenance mechanisms in cancer

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  • Site-wide: 7,507 out of 100,856
  • In genomics: 1,142 out of 6,254
• Year to date:
  • Site-wide: 22,963 out of 100,856
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  • Site-wide: 28,096 out of 100,856

ACEseq - allele specific copy number estimation from whole genome sequencing

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  • Site-wide: 9,486 out of 100,856
  • In bioinformatics: 1,551 out of 9,260
• Year to date:
  • Site-wide: 25,454 out of 100,856
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  • Site-wide: 21,505 out of 100,856

Framework For Quality Assessment Of Whole Genome, Cancer Sequences

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  • In genomics: 1,682 out of 6,254
• Year to date:
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  • Site-wide: 42,164 out of 100,856

Resolving Drug Effects In Patient-Derived Cancer Cells Links Organoid Responses To Genome Alterations

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  • In cancer biology: 456 out of 3,613
• Year to date:
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  • Site-wide: 91,964 out of 100,856

Dissecting intratumor heterogeneity of nodal B cell lymphomas on the transcriptional, genetic, and drug response level

• Downloaded 849 times
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  • In cancer biology: 512 out of 3,613
• Year to date:
  • Site-wide: 5,155 out of 100,856
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  • Site-wide: 13,821 out of 100,856

Identification and prioritisation of causal variants in human genetic disorders from exome or whole genome sequencing data

• Downloaded 692 times
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  • In bioinformatics: 3,299 out of 9,260
• Year to date:
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  • Site-wide: 65,688 out of 100,856

HTSlib-js: Developer toolkit for a client-side JavaScript interface for HTSlib

• Downloaded 349 times
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  • Site-wide: 53,768 out of 100,856
  • In bioinformatics: 6,042 out of 9,260
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  • Site-wide: 73,646 out of 100,856

Reprogramming of stromal fibroblasts by chemotherapy-induced secretion of IFNβ1 drives re-growth of breast cancer cells after treatment.

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  • Site-wide: 86,629 out of 100,856
  • In cancer biology: 2,964 out of 3,613
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  • Site-wide: 9,260 out of 100,856