Author: Anders D Børglum

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Preprints

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

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  • Site-wide: 4,685

Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism

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  • Site-wide: 743
  • In genetics: 22
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  • Site-wide: 3,822
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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 818
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Common risk variants identified in autism spectrum disorder

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  • Site-wide: 1,049
  • In genetics: 34
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  • Site-wide: 2,016
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  • Site-wide: 1,977

Psychiatric Genomics: An Update and an Agenda

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  • Site-wide: 3,321
  • In genetics: 134
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  • Site-wide: 61,258
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A Major Role for Common Genetic Variation in Anxiety Disorders

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  • Site-wide: 3,687
  • In genetics: 162
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Genetic analyses identify widespread sex-differential participation bias

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  • Site-wide: 3,743
  • In genetics: 164
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  • Site-wide: 6,563
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Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

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  • Site-wide: 5,244
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• Year to date:
  • Site-wide: 12,222
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Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

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  • Site-wide: 5,451
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• Year to date:
  • Site-wide: 70,135
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Genome-wide analyses of self-reported empathy: correlations with autism, schizophrenia, and anorexia nervosa

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  • Site-wide: 6,551
  • In genomics: 744
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  • Site-wide: 32,689

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 8,317
  • In genetics: 405
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  • Site-wide: 31,706
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ASD and ADHD have a similar burden of rare protein-truncating variants

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  • Site-wide: 8,768
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  • Site-wide: 22,967

Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

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  • Site-wide: 9,188
  • In genetics: 452
• Year to date:
  • Site-wide: 75,586
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  • Site-wide: 64,273

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

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  • Site-wide: 9,230
  • In genetics: 456
• Year to date:
  • Site-wide: 16,201
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  • Site-wide: 14,280

Genetic Architecture of 11 Major Psychiatric Disorders at Biobehavioral, Functional Genomic, and Molecular Genetic Levels of Analysis

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  • Site-wide: 11,862
  • In genetic and genomic medicine: 39
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  • Site-wide: 2,315
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  • Site-wide: 1,213

A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder

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  • Site-wide: 11,956
  • In genetics: 601
• Year to date:
  • Site-wide: 40,813
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Genome-wide Association Study of Anxiety and Stress-related Disorders in the iPSYCH Cohort

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  • Site-wide: 13,710
  • In genetics: 698
• Year to date:
  • Site-wide: 57,586
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A genome-wide association study for shared risk across major psychiatric disorders in a nation-wide birth cohort implicates fetal neurodevelopment as a key mediator

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  • Site-wide: 15,909
  • In genetics: 805
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  • Site-wide: 75,542
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Gene expression imputation across multiple brain regions reveals schizophrenia risk throughout development.

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  • Site-wide: 16,750
  • In genetics: 846
• Year to date:
  • Site-wide: 75,433
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  • Site-wide: 57,847

Genome-wide association study of school grades identifies a genetic overlap between language ability, psychopathology and creativity

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  • Site-wide: 17,682
  • In genomics: 1,841
• Year to date:
  • Site-wide: 17,200
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  • Site-wide: 27,382

Mitochondrial DNA SNPs associated with Schizophrenia exhibit Highly Variable Inter-allelic Haplogroup Affiliation and Nuclear Genogeographic Affinity: Bi-Genomic Linkage Disequilibrium raises Major Concerns for Link to Disease

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  • Site-wide: 18,014
  • In genomics: 1,870
• Year to date:
  • Site-wide: 44,793
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  • Site-wide: 32,864

Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality

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  • Site-wide: 18,062
  • In genetics: 905
• Year to date:
  • Site-wide: 26,626
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  • Site-wide: 25,328

Transcriptomic Imputation of Bipolar Disorder and Bipolar subtypes reveals 29 novel associated genes

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  • Site-wide: 21,921
  • In genetics: 1,077
• Year to date:
  • Site-wide: 48,406
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  • Site-wide: 53,179

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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  • Site-wide: 23,215
  • In genetics: 1,150
• Year to date:
  • Site-wide: 3,545
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  • Site-wide: 2,711

Complex spatio-temporal distribution and genogeographic affinity of mitochondrial DNA haplogroups in 24,216 Danes

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  • Site-wide: 23,361
  • In genomics: 2,285
• Year to date:
  • Site-wide: 51,570
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  • Site-wide: 41,497

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

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  • Site-wide: 25,668
  • In genetics: 1,270
• Year to date:
  • Site-wide: 69,830
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  • Site-wide: 59,088

Shared risk alleles with discordant polygenic effects: Disentangling the genetic overlap between ASD and ADHD

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  • Site-wide: 26,512
  • In genetics: 1,318
• Year to date:
  • Site-wide: 60,721
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  • Site-wide: 43,551

Genetic markers of ADHD-related variations in intracranial volume

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  • Site-wide: 26,894
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• Year to date:
  • Site-wide: 55,458
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  • Site-wide: 57,858

The iPSYCH2012 case-cohort sample: New directions for unravelling genetic and environmental architectures of severe mental disorders

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  • Site-wide: 28,520
  • In genetics: 1,420
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  • Site-wide: 48,416
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  • Site-wide: 37,047

Social and non-social autism symptom and trait domains are genetically dissociable

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  • Site-wide: 29,284
  • In genetics: 1,454
• Year to date:
  • Site-wide: 34,355
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  • Site-wide: 49,842

Disentangling genetically confounded polygenic associations between Attention-Deficit/Hyperactivity Disorder, literacy and language

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  • Site-wide: 31,185
  • In genetics: 1,547
• Year to date:
  • Site-wide: 73,960
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  • Site-wide: 101,418

Shared genetic background between children and adults with attention deficit/hyperactivity disorder

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  • Site-wide: 33,173
  • In genetics: 1,634
• Year to date:
  • Site-wide: 71,691
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  • Site-wide: 61,482

Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

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  • Site-wide: 33,340
  • In genetics: 1,646
• Year to date:
  • Site-wide: 18,474
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  • Site-wide: 26,269

Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization

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  • Site-wide: 33,898
  • In genetics: 1,662
• Year to date:
  • Site-wide: 80,866
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  • Site-wide: 59,500

Investigating the Association Between Body Fat and Depression via Mendelian Randomization

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  • Site-wide: 34,348
  • In genetics: 1,681
• Year to date:
  • Site-wide: 85,358
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  • Site-wide: 52,007

The neurobiology of BRD1 implicates sex-biased dysregulation of nuclear receptor signaling in mental disorders

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  • Site-wide: 36,053
  • In neuroscience: 5,112
• Year to date:
  • Site-wide: 57,271
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  • Site-wide: 49,517

Elevated polygenic burden for autism is associated with differential DNA methylation at birth.

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  • Site-wide: 36,896
  • In genetics: 1,800
• Year to date:
  • Site-wide: 85,649
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  • Site-wide: 79,799

Identification of risk variants and characterization of the polygenic architecture of disruptive behavior disorders in the context of ADHD

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  • Site-wide: 43,242
  • In genomics: 3,553
• Year to date:
  • Site-wide: 39,587
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  • Site-wide: 41,089

Estimating the functional impact of INDELs in transcription factor binding sites: a genome-wide landscape

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  • Site-wide: 44,970
  • In bioinformatics: 4,781
• Year to date:
  • Site-wide: 92,963
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  • Site-wide: 62,464

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration

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  • Site-wide: 49,064
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  • Site-wide: 95,997

Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction

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  • Site-wide: 56,673
  • In genetics: 2,691
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  • Site-wide: 27,104
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  • Site-wide: 20,303

Meta-analysis of Scandinavian Schizophrenia Exomes

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  • Site-wide: 57,597
  • In genetics: 2,722
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  • Site-wide: 40,943
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  • Site-wide: 43,347

Gestational-age-dependent development of the neonatal metabolome

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  • Site-wide: 58,041
  • In pediatrics: 55
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  • Site-wide: 50,590
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  • Site-wide: 39,918

Does Neuroticism Cause Depression? A Mendelian Randomization Study

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  • Site-wide: 60,540
  • In genetics: 2,871
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  • Site-wide: 119,583
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  • Site-wide: 105,499

Polygenic prediction of school performance in children with and without psychiatric disorders

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  • Site-wide: 77,341
  • In genetics: 3,586
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  • Site-wide: 52,628
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  • Site-wide: 38,217

Genetic factors underlying the bidirectional relationship between autoimmune and mental disorders – findings from a Danish population-based study

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  • Site-wide: 87,168
  • In bioinformatics: 7,765
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Intellectual Disability-related genes increase ADHD risk and locomotor activity in Drosophila

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  • Site-wide: 88,784
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  • Site-wide: 60,247

The iPSYCH2015 Case-Cohort sample: updated directions for unravelling genetic and environmental architectures of severe mental disorders

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  • Site-wide: 117,571
  • In epidemiology: 4,756
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  • Site-wide: 22,356
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Genome-wide association study of febrile seizures identifies seven new loci implicating fever response and neuronal excitability genes

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  • Site-wide: 119,911
  • In genetic and genomic medicine: 545
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