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Author: David A. Agard

Rankings

  • All-time downloads: 197,815 (rank: 90 out of 425,626)
  • Categories:
    • biochemistry: 3,940 (rank: 425 out of 20,738)
    • biophysics: 17,448 (rank: 31 out of 18,153)
    • cell biology: 2,162 (rank: 1,882 out of 32,720)
    • microbiology: 4,650 (rank: 1,939 out of 50,319)
    • molecular biology: 582 (rank: 8,045 (tie) out of 23,380)
    • neuroscience: 563 (rank: 31,455 (tie) out of 71,945)
    • systems biology: 168,470 (rank: 18 (tie) out of 12,451)

Downloads per author, site-wide

Preprints

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

systems biology more details view paper
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    • In systems biology: 1 out of 2,561
  • Year to date:
    • Site-wide: 4 out of 100,745
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    • Site-wide: 23 out of 100,745

Anisotropic Correction of Beam-induced Motion for Improved Single-particle Electron Cryo-microscopy

biophysics more details view paper
  • Downloaded 6,863 times
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    • Site-wide: 512 out of 100,745
    • In biophysics: 11 out of 4,441
  • Year to date:
    • Site-wide: 7,140 out of 100,745
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    • Site-wide: 10,111 out of 100,745

A simple and robust procedure for preparing graphene-oxide cryo-EM grids

biophysics more details view paper
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    • In biophysics: 17 out of 4,441
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A nucleus-like compartment shields bacteriophage DNA from CRISPR-Cas and restriction nucleases

microbiology more details view paper
  • Downloaded 2,672 times
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    • In microbiology: 215 out of 8,937
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    • Site-wide: 7,383 out of 100,745
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    • Site-wide: None out of 100,745

Atomic structure of Hsp90:Cdc37:Cdk4 reveals Hsp90 regulates kinase via dramatic unfolding

biochemistry more details view paper
  • Downloaded 2,414 times
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    • In biochemistry: 74 out of 3,442
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General and robust covalently linked graphene oxide affinity grids for high-resolution cryo-EM

biophysics more details view paper
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    • In biophysics: 121 out of 4,441
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    • Site-wide: 11,897 out of 100,745

A molecular pore spans the double membrane of the coronavirus replication organelle

microbiology more details view paper
  • Downloaded 1,254 times
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    • In microbiology: 589 out of 8,937
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Microtubules form by progressively faster tubulin accretion, not by nucleation-elongation

cell biology more details view paper
  • Downloaded 1,221 times
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    • Site-wide: 9,521 out of 100,745
    • In cell biology: 355 out of 5,214
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    • Site-wide: 19,266 out of 100,745

Amino and PEG-Amino Graphene Oxide Grids Enrich and Protect Samples for High-resolution Single Particle Cryo-electron Microscopy

biophysics more details view paper
  • Downloaded 1,092 times
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    • Site-wide: 11,448 out of 100,745
    • In biophysics: 360 out of 4,441
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    • Site-wide: 10,532 out of 100,745
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    • Site-wide: 16,038 out of 100,745

The Atomic Structure of the Microtubule-Nucleating γ-Tubulin Small Complex and its Implications for Regulation

biophysics more details view paper
  • Downloaded 1,017 times
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    • Site-wide: 12,844 out of 100,745
    • In biophysics: 420 out of 4,441
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    • Site-wide: 24,862 out of 100,745

Structural Basis of Mitochondrial Receptor Binding and GTP Driven Conformational Constriction by Dynamin-Related Protein 1

biophysics more details view paper
  • Downloaded 902 times
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    • Site-wide: 15,606 out of 100,745
    • In biophysics: 528 out of 4,441
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    • Site-wide: 47,240 out of 100,745

Mind the gap: micro-expansion joints drastically decrease the bending of FIB-milled cryo-lamellae

microbiology more details view paper
  • Downloaded 724 times
  • Download rankings, all-time:
    • Site-wide: 21,743 out of 100,745
    • In microbiology: 1,439 out of 8,937
  • Year to date:
    • Site-wide: 53,591 out of 100,745
  • Since beginning of last month:
    • Site-wide: 38,468 out of 100,745

Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1

molecular biology more details view paper
  • Downloaded 576 times
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    • Site-wide: 30,036 out of 100,745
    • In molecular biology: 999 out of 3,497
  • Year to date:
    • Site-wide: 81,041 out of 100,745
  • Since beginning of last month:
    • Site-wide: 46,660 out of 100,745

Electron Cryo-Tomography Provides Insight into Procentriole Architecture and Assembly Mechanism

cell biology more details view paper
  • Downloaded 563 times
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    • Site-wide: 30,880 out of 100,745
    • In cell biology: 1,457 out of 5,214
  • Year to date:
    • Site-wide: 84,281 out of 100,745
  • Since beginning of last month:
    • Site-wide: 72,119 out of 100,745

Modulation of mitochondrial Hsp90 (TRAP1) ATPase activity by calcium and magnesium

biochemistry more details view paper
  • Downloaded 523 times
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    • In biochemistry: 988 out of 3,442
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    • Site-wide: 69,354 out of 100,745

Spc110 N-Terminal Domains Act Independently to Mediate Stable γ-Tubulin Small Complex Binding and γ-Tubulin Ring Complex Assembly

biochemistry more details view paper
  • Downloaded 520 times
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    • In biochemistry: 1,000 out of 3,442
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    • Site-wide: 72,545 out of 100,745

Mechanistic Origins of Dynamic Instability in Filaments from the Phage Tubulin, PhuZ

cell biology more details view paper
  • Downloaded 378 times
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    • Site-wide: 49,061 out of 100,745
    • In cell biology: 2,475 out of 5,214
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    • Site-wide: 53,042 out of 100,745
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    • Site-wide: 53,692 out of 100,745

GR chaperone cycle mechanism revealed by cryo-EM: reactivation of GR by the GR:Hsp90:p23 client-maturation complex

biophysics more details view paper
  • Downloaded 350 times
  • Download rankings, all-time:
    • Site-wide: 52,818 out of 100,745
    • In biophysics: 2,223 out of 4,441
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    • Site-wide: 12,535 out of 100,745
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    • Site-wide: 758 out of 100,745

Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions

neuroscience more details view paper
  • Downloaded 315 times
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    • In neuroscience: 10,118 out of 17,945
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    • Site-wide: 84,765 out of 100,745
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    • Site-wide: None out of 100,745

Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1

biophysics more details view paper
  • Downloaded 291 times
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    • Site-wide: 61,674 out of 100,745
    • In biophysics: 2,665 out of 4,441
  • Year to date:
    • Site-wide: 16,417 out of 100,745
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    • Site-wide: 3,875 out of 100,745

The centrosomin CM2 domain is a multi-functional binding domain with distinct cell cycle roles

biochemistry more details view paper
  • Downloaded 254 times
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    • Site-wide: 67,921 out of 100,745
    • In biochemistry: 2,197 out of 3,442
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    • Site-wide: 80,389 out of 100,745

Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism

neuroscience more details view paper
  • Downloaded 248 times
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    • Site-wide: 68,939 out of 100,745
    • In neuroscience: 12,152 out of 17,945
  • Year to date:
    • Site-wide: 20,633 out of 100,745
  • Since beginning of last month:
    • Site-wide: 14,189 out of 100,745

XMAP215 and γ-tubulin additively promote microtubule nucleation in purified solutions

biochemistry more details view paper
  • Downloaded 229 times
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    • In biochemistry: 2,349 out of 3,442
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    • Site-wide: 27,324 out of 100,745

Cryo-EM reveals the dynamic interplay between mitochondrial Hsp90 and SdhB folding intermediates

biophysics more details view paper
  • Downloaded 28 times
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    • Site-wide: 98,240 out of 100,745
    • In biophysics: 4,332 out of 4,441
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    • Site-wide: 98,177 out of 100,745
  • Since beginning of last month:
    • Site-wide: 26,576 out of 100,745

Proteomic analysis of microtubule inner proteins (MIPs) in Rib72 null Tetrahymena cells reveals functional MIPs

molecular biology more details view paper
  • Downloaded 6 times
  • Download rankings, all-time:
    • Site-wide: 99,084 out of 100,745
    • In molecular biology: 3,434 out of 3,497
  • Year to date:
    • Site-wide: 99,072 out of 100,745
  • Since beginning of last month:
    • Site-wide: 75,129 out of 100,745
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