Author: Christopher D. Brown

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Preprints

The GTEx Consortium atlas of genetic regulatory effects across human tissues

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  • Site-wide: 1,025
  • In genetics: 29
• Year to date:
  • Site-wide: 4,340
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  • Site-wide: 6,617

Local genetic effects on gene expression across 44 human tissues

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  • Site-wide: 2,330
  • In genomics: 257
• Year to date:
  • Site-wide: 59,390
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  • Site-wide: 55,578

Exploiting the GTEx resources to decipher the mechanisms at GWAS loci

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  • Site-wide: 3,308
  • In genetics: 130
• Year to date:
  • Site-wide: 4,311
• Since beginning of last month:
  • Site-wide: 4,070

Distant regulatory effects of genetic variation in multiple human tissues

• Downloaded 2,765 times
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  • Site-wide: 4,601
  • In genomics: 513
• Year to date:
  • Site-wide: 68,032
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  • Site-wide: 72,562

Transposable element exaptation is the primary source of novelty in the primate gene regulatory landscape

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  • Site-wide: 8,081
  • In genomics: 884
• Year to date:
  • Site-wide: 40,900
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  • Site-wide: 40,733

Many long intergenic non-coding RNAs distally regulate mRNA gene expression levels

• Downloaded 1,634 times
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  • Site-wide: 10,041
  • In genomics: 1,094
• Year to date:
  • Site-wide: 92,525
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  • Site-wide: 93,289

Transposable elements generate regulatory novelty in a tissue-specific fashion

• Downloaded 1,409 times
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  • Site-wide: 12,493
  • In genomics: 1,348
• Year to date:
  • Site-wide: 76,397
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  • Site-wide: 64,714

Mechanisms of tissue-specific genetic regulation revealed by latent factors across eQTLs

• Downloaded 1,406 times
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  • Site-wide: 12,541
  • In genomics: 1,354
• Year to date:
  • Site-wide: 40,438
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  • Site-wide: 37,688

High throughput characterization of genetic effects on DNA:protein binding and gene transcription

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  • Site-wide: 16,969
  • In genetics: 834
• Year to date:
  • Site-wide: 111,248
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  • Site-wide: 108,315

A genome-wide association study for nonalcoholic fatty liver disease identifies novel genetic loci and trait-relevant candidate genes in the Million Veteran Program.

• Downloaded 1,017 times
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  • Site-wide: 20,381
  • In genetic and genomic medicine: 69
• Year to date:
  • Site-wide: 1,028
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  • Site-wide: 3,284

Impact of admixture and ancestry on eQTL analysis and GWAS colocalization in GTEx

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  • Site-wide: 25,280
  • In genetics: 1,223
• Year to date:
  • Site-wide: 45,757
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  • Site-wide: 56,417

Longitudinal immune profiling of mild and severe COVID-19 reveals innate and adaptive immune dysfunction and provides an early prediction tool for clinical progression

• Downloaded 814 times
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  • Site-wide: 27,947
  • In infectious diseases: 1,973
• Year to date:
  • Site-wide: 22,363
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  • Site-wide: 26,286

Genetic And Epigenetic Fine Mapping Of Complex Trait Associated Loci In The Human Liver

• Downloaded 761 times
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  • Site-wide: 30,725
  • In genetics: 1,488
• Year to date:
  • Site-wide: 102,594
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  • Site-wide: 104,738

Inferring the molecular mechanisms of noncoding Alzheimer's disease-associated genetic variants

• Downloaded 746 times
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  • Site-wide: 31,576
  • In bioinformatics: 3,554
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  • Site-wide: 61,930
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  • Site-wide: 47,319

INFERNO - INFERring the molecular mechanisms of NOncoding genetic variants

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  • Site-wide: 32,887
  • In bioinformatics: 3,685
• Year to date:
  • Site-wide: 101,325
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  • Site-wide: 123,024

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments

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  • Site-wide: 38,011
  • In genetics: 1,814
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  • Site-wide: 12,212
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  • Site-wide: 18,105

A dementia-associated risk variant near TMEM106B alters chromatin architecture and gene expression

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  • Site-wide: 39,718
  • In genetics: 1,887
• Year to date:
  • Site-wide: 120,950
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  • Site-wide: 116,076

Multiplexed targeted resequencing identifies coding and regulatory variation underlying phenotypic extremes of HDL-cholesterol in humans

• Downloaded 361 times
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  • Site-wide: 73,000
  • In genomics: 4,998
• Year to date:
  • Site-wide: 112,255
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  • Site-wide: 93,470

Genomic architecture of Shh dependent cochlear morphogenesis

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  • Site-wide: 85,350
  • In developmental biology: 2,316
• Year to date:
  • Site-wide: 125,093
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  • Site-wide: 126,227