Author: Andrew B. Ward

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Preprints

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

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  • Site-wide: 16,990

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

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  • Site-wide: 2,580
  • In microbiology: 179
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  • Site-wide: 8,366
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  • Site-wide: 10,117

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

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  • Site-wide: 4,365
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Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

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  • Site-wide: 5,314
  • In immunology: 134
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Cryo-EM structure of the mechanically activated ion channel OSCA1.2

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  • Site-wide: 6,886
  • In biophysics: 136
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  • Site-wide: 27,358

Cross-reactive serum and memory B cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection

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  • Site-wide: 7,788
  • In immunology: 202
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  • Site-wide: 4,009
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  • Site-wide: 3,257

Structure of the SARS-CoV NSP12 polymerase bound to NSP7 and NSP8 co-factors

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  • Site-wide: 8,812
  • In biophysics: 194
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  • Site-wide: 20,931

OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels

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  • Site-wide: 10,786
  • In biophysics: 254
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  • Site-wide: 101,550
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  • Site-wide: 45,429

Tailored Design of Protein Nanoparticle Scaffolds for Multivalent Presentation of Viral Glycoprotein Antigens

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  • Site-wide: 11,213
  • In synthetic biology: 127
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  • Site-wide: 15,532
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  • Site-wide: 24,983

Structures of the Otopetrin Proton Channels Otop1 and Otop3

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  • Site-wide: 12,550
  • In biochemistry: 245
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Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

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  • Site-wide: 14,142
  • In immunology: 377
• Year to date:
  • Site-wide: 82,825
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  • Site-wide: 108,932

Visualization of the HIV-1 Env Glycan Shield Across Scales

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  • Site-wide: 17,049
  • In biophysics: 448
• Year to date:
  • Site-wide: 58,135
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  • Site-wide: 80,078

Receptor binding and proteolysis do not induce large conformational changes in the SARS-CoV spike

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  • Site-wide: 19,411
  • In biochemistry: 411
• Year to date:
  • Site-wide: 95,338
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Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts

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  • Site-wide: 20,576
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  • Site-wide: 74,974
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  • Site-wide: 119,180

Structure and immune recognition of the porcine epidemic diarrhea virus spike protein

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  • Site-wide: 22,749
  • In biophysics: 639
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  • Site-wide: 24,047
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  • Site-wide: 35,393

Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity

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  • Site-wide: 23,585
  • In microbiology: 1,345
• Year to date:
  • Site-wide: 20,934
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  • Site-wide: 19,352

An alternative binding mode of IGHV3-53 antibodies to the SARS-CoV-2 receptor binding domain

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  • Site-wide: 27,463
  • In microbiology: 1,615
• Year to date:
  • Site-wide: 17,271
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  • Site-wide: 9,682

Structure of the Ebola virus nucleoprotein - RNA complex

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  • Site-wide: 32,068
  • In biophysics: 1,022
• Year to date:
  • Site-wide: 35,264
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  • Site-wide: 79,411

Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

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  • Site-wide: 32,574
  • In immunology: 866
• Year to date:
  • Site-wide: 16,037
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  • Site-wide: 43,635

Targeting HIV Env immunogens to B cell follicles in non-human primates through immune complex or protein nanoparticle formulations

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  • Site-wide: 33,699
  • In immunology: 893
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  • Site-wide: 23,472
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  • Site-wide: 58,795

HIV-1 vaccine design through minimizing envelope metastability

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  • Site-wide: 33,998
  • In microbiology: 2,018
• Year to date:
  • Site-wide: 97,862
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  • Site-wide: 79,907

HIV-1 Envelope and MPER antibody structures in lipid assemblies

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  • Site-wide: 39,563
  • In immunology: 1,037
• Year to date:
  • Site-wide: 49,843
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  • Site-wide: 76,474

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

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  • Site-wide: 41,407
  • In immunology: 1,089
• Year to date:
  • Site-wide: 63,119
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  • Site-wide: 40,651

Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates

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  • Site-wide: 42,749
  • In immunology: 1,120
• Year to date:
  • Site-wide: 25,127
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  • Site-wide: 79,234

Mapping polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines

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  • Site-wide: 43,137
  • In immunology: 1,136
• Year to date:
  • Site-wide: 112,761
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  • Site-wide: 62,792

A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody

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  • Site-wide: 44,026
  • In microbiology: 2,739
• Year to date:
  • Site-wide: 13,456
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  • Site-wide: 16,407

Chimpanzee SIV Envelope trimer: structure and deployment as an HIV vaccine template

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  • Site-wide: 45,106
  • In immunology: 1,200
• Year to date:
  • Site-wide: 94,655
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  • Site-wide: 82,767

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

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  • Site-wide: 46,327
  • In immunology: 1,233
• Year to date:
  • Site-wide: 7,432
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  • Site-wide: 8,319

Quantification of the Resilience and Vulnerability of HIV-1 Native Glycan Shield at Atomistic Detail

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  • Site-wide: 50,361
  • In biophysics: 1,742
• Year to date:
  • Site-wide: 73,198
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  • Site-wide: 40,028

Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor binding head domains

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  • Site-wide: 54,429
  • In immunology: 1,444
• Year to date:
  • Site-wide: 107,930
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  • Site-wide: 106,906

Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics

• Downloaded 438 times
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  • Site-wide: 54,825
  • In immunology: 1,455
• Year to date:
  • Site-wide: 107,298
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  • Site-wide: 120,202

Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins

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  • Site-wide: 57,964
  • In molecular biology: 1,668
• Year to date:
  • Site-wide: 40,860
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  • Site-wide: 12,406

Polyclonal epitope cartography reveals the temporal dynamics and diversity of human antibody responses to H5N1 vaccination

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  • Site-wide: 58,370
  • In immunology: 1,543
• Year to date:
  • Site-wide: 10,028
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  • Site-wide: 26,566

EMHP: An accurate automated hole masking algorithm for single-particle cryo-EM image processing

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  • Site-wide: 61,531
  • In bioinformatics: 6,103
• Year to date:
  • Site-wide: 115,599
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  • Site-wide: 118,416

Neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened

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  • Site-wide: 74,112
  • In immunology: 1,983
• Year to date:
  • Site-wide: 112,482
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  • Site-wide: 89,541

HIV Envelope Trimer-Elicited Autologous Neutralizing Antibodies Bind a Region Overlapping the N332 Glycan Supersite

• Downloaded 287 times
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  • Site-wide: 79,777
  • In immunology: 2,131
• Year to date:
  • Site-wide: 103,185
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  • Site-wide: 97,623

Networks of HIV-1 envelope glycans maintain antibody epitopes in the face of glycan additions and deletions

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  • Site-wide: 85,977
  • In immunology: 2,325
• Year to date:
  • Site-wide: 122,684
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  • Site-wide: 91,620

Convergence of a common solution to broad ebolavirus neutralization by glycan cap directed human antibodies

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  • Site-wide: 94,365
  • In immunology: 2,574
• Year to date:
  • Site-wide: 49,927
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  • Site-wide: 54,363

A strain-specific inhibitor of receptor-bound HIV-1 targets a pocket near the fusion peptide and offers a template for drug design

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  • Site-wide: 96,152
  • In biophysics: 3,735
• Year to date:
  • Site-wide: 57,662
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  • Site-wide: 91,686

Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike

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  • Site-wide: 97,502
  • In biochemistry: 2,853
• Year to date:
  • Site-wide: 22,721
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  • Site-wide: 46,665

High-resolution mapping of the neutralizing and binding specificities of polyclonal rabbit serum elicited by HIV Env trimer immunization

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  • Site-wide: 100,137
  • In microbiology: 7,482
• Year to date:
  • Site-wide: 51,000
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  • Site-wide: 36,450

Canonical features of human antibodies recognizing the influenza hemagglutinin trimer interface

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  • Site-wide: 105,200
  • In immunology: 2,884
• Year to date:
  • Site-wide: 1,433
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Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer

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  • Site-wide: 110,237
  • In immunology: 3,042
• Year to date:
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  • Site-wide: 40,398

Neutralizing antibodies induced by first-generation gp41-stabilized HIV-1 envelope trimers and nanoparticles

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  • Site-wide: 113,397
  • In microbiology: 8,673
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  • Site-wide: 54,249
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  • Site-wide: 4,840

Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles

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  • Site-wide: 116,440
  • In microbiology: 8,955
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  • Site-wide: 7,086