Author: Joel Gelernter

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Preprints

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

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  • Site-wide: 669
  • In genetics: 18
• Year to date:
  • Site-wide: 5,848
• Since beginning of last month:
  • Site-wide: 4,854

Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use

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  • Site-wide: 917
  • In genetics: 27
• Year to date:
  • Site-wide: 52,891
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  • Site-wide: None

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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  • Site-wide: 2,025
  • In genomics: 215
• Year to date:
  • Site-wide: 10,731
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  • Site-wide: 9,914

Psychiatric Genomics: An Update and an Agenda

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  • Site-wide: 3,317
  • In genetics: 134
• Year to date:
  • Site-wide: 54,859
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  • Site-wide: 50,263

Multivariate genomic analysis of 1.5 million people identifies genes related to addiction, antisocial behavior, and health

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  • Site-wide: 5,478
  • In genetics: 262
• Year to date:
  • Site-wide: 3,039
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  • Site-wide: 2,379

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

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  • Site-wide: 7,735
  • In genetics: 370
• Year to date:
  • Site-wide: 63,009
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  • Site-wide: 63,671

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

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  • Site-wide: 9,243
  • In genetics: 457
• Year to date:
  • Site-wide: 16,494
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  • Site-wide: 14,858

GWAS of Depression Phenotypes in the Million Veteran Program and Meta-analysis in More than 1.2 Million Participants Yields 178 Independent Risk Loci

• Downloaded 1,597 times
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  • Site-wide: 9,812
  • In genetic and genomic medicine: 31
• Year to date:
  • Site-wide: 5,317
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  • Site-wide: 4,320

Genome-wide association study of over 40,000 bipolar disorder cases provides novel biological insights

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  • Site-wide: 10,173
  • In psychiatry and clinical psychology: 32
• Year to date:
  • Site-wide: 2,798
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  • Site-wide: 3,556

Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality

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  • Site-wide: 17,874
  • In genetics: 899
• Year to date:
  • Site-wide: 23,486
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  • Site-wide: 18,482

Genomic Characterization of Posttraumatic Stress Disorder in a Large US Military Veteran Sample

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  • Site-wide: 19,339
  • In genetics: 962
• Year to date:
  • Site-wide: 7,464
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  • Site-wide: 5,163

Mediated pleiotropy between psychiatric disorders and autoimmune disorders revealed by integrative analysis of multiple GWAS

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  • Site-wide: 21,253
  • In genomics: 2,128
• Year to date:
  • Site-wide: 81,004
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  • Site-wide: 52,371

Dissecting the genetic overlap of education, socioeconomic status, and mental health

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  • Site-wide: 25,787
  • In psychiatry and clinical psychology: 77
• Year to date:
  • Site-wide: 41,863
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  • Site-wide: 40,599

Measuring genetic variation in the multi-ethnic Million Veteran Program (MVP)

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  • Site-wide: 25,782
  • In genetics: 1,278
• Year to date:
  • Site-wide: 35,573
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  • Site-wide: None

Genome-wide Association Study of Alcohol Consumption and Use Disorder in Multiple Populations (N = 274,424)

• Downloaded 827 times
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  • Site-wide: 25,876
  • In genetics: 1,283
• Year to date:
  • Site-wide: 95,125
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  • Site-wide: None

Reproducible Risk Loci and Psychiatric Comorbidities in Anxiety: Results from ~200,000 Million Veteran Program Participants

• Downloaded 747 times
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  • Site-wide: 29,852
  • In genetics: 1,474
• Year to date:
  • Site-wide: 100,812
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  • Site-wide: None

Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium

• Downloaded 732 times
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  • Site-wide: 30,635
  • In genetics: 1,520
• Year to date:
  • Site-wide: 19,694
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  • Site-wide: 11,075

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

• Downloaded 711 times
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  • Site-wide: 31,961
  • In genetics: 1,588
• Year to date:
  • Site-wide: 107,334
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  • Site-wide: 88,282

Genetic Data Can Lead to Medical Discrimination: Opioid Use Disorder as a Cautionary Tale

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  • Site-wide: 32,198
  • In addiction medicine: 6
• Year to date:
  • Site-wide: 7,238
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  • Site-wide: 12,547

GWAS including 82,707 subjects identifies functional coding variant in OPRM1 gene associated with opioid use disorder

• Downloaded 671 times
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  • Site-wide: 34,513
  • In genetic and genomic medicine: 101
• Year to date:
  • Site-wide: 46,645
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  • Site-wide: 27,584

Transcriptomic Organization of Human Posttraumatic Stress Disorder

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  • Site-wide: 34,732
  • In genomics: 3,052
• Year to date:
  • Site-wide: 32,768
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  • Site-wide: None

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

• Downloaded 633 times
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  • Site-wide: 37,287
  • In genetics: 1,816
• Year to date:
  • Site-wide: 15,110
• Since beginning of last month:
  • Site-wide: 6,622

Expanding the Genetic Architecture of Nicotine Dependence and its Shared Genetics with Multiple Traits: Findings from the Nicotine Dependence GenOmics (iNDiGO) Consortium

• Downloaded 551 times
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  • Site-wide: 44,415
  • In genomics: 3,623
• Year to date:
  • Site-wide: 44,290
• Since beginning of last month:
  • Site-wide: 33,049

Genomewide Analyses of Psychological Resilience in US Army Soldiers

• Downloaded 534 times
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  • Site-wide: 46,137
  • In genetics: 2,218
• Year to date:
  • Site-wide: 100,766
• Since beginning of last month:
  • Site-wide: 93,791

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

• Downloaded 414 times
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  • Site-wide: 60,945
  • In genetic and genomic medicine: 182
• Year to date:
  • Site-wide: 10,955
• Since beginning of last month:
  • Site-wide: 17,772

Metabolome-Wide Mendelian Randomization Analysis of Emotional and Behavioral Responses to Traumatic Stress

• Downloaded 411 times
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  • Site-wide: 61,506
  • In genetics: 2,917
• Year to date:
  • Site-wide: 70,898
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  • Site-wide: 51,902

Natural selection influenced the genetic architecture of brain structure, behavioral and neuropsychiatric traits

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  • Site-wide: 65,488
  • In evolutionary biology: 3,653
• Year to date:
  • Site-wide: 86,756
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  • Site-wide: None

Genomic Influences on Self-Reported Childhood Maltreatment

• Downloaded 373 times
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  • Site-wide: 67,498
  • In genomics: 4,769
• Year to date:
  • Site-wide: 105,193
• Since beginning of last month:
  • Site-wide: 82,179

DRD2 and FOXP2 are implicated in the associations between computerized device use and psychiatric disorders

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  • Site-wide: 70,505
  • In genomics: 4,906
• Year to date:
  • Site-wide: 52,621
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  • Site-wide: 44,434

Alcohol-responsive genes identified in human iPSC-derived neural cultures

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  • Site-wide: 71,879
  • In neuroscience: 11,070
• Year to date:
  • Site-wide: 72,954
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  • Site-wide: 53,957

Trauma and posttraumatic stress interact with sex-specific risk loci for suicidality and converge on brain extracellular matrix biology and synaptic plasticity

• Downloaded 334 times
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  • Site-wide: 74,150
  • In psychiatry and clinical psychology: 224
• Year to date:
  • Site-wide: 51,447
• Since beginning of last month:
  • Site-wide: 27,996

Retrospective Association Analysis of Longitudinal Binary Traits Identifies Important Loci and Pathways in Cocaine Use

• Downloaded 326 times
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  • Site-wide: 75,595
  • In genetics: 3,517
• Year to date:
  • Site-wide: 59,392
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  • Site-wide: 59,531

The effect of the genetic liability to autism spectrum disorder on emotion recognition in young unaffected probands from a population-based cohort

• Downloaded 324 times
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  • Site-wide: 76,008
  • In psychiatry and clinical psychology: 231
• Year to date:
  • Site-wide: 100,305
• Since beginning of last month:
  • Site-wide: 100,393

Dissecting the association of C-reactive protein levels with PTSD, traumatic events, and social support

• Downloaded 295 times
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  • Site-wide: 81,631
  • In psychiatry and clinical psychology: 259
• Year to date:
  • Site-wide: 24,667
• Since beginning of last month:
  • Site-wide: 36,423

Economic status mediates the relationship between educational attainment and posttraumatic stress disorder: a multivariable Mendelian randomization study

• Downloaded 283 times
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  • Site-wide: 84,151
  • In genetics: 3,863
• Year to date:
  • Site-wide: 115,532
• Since beginning of last month:
  • Site-wide: 74,258

Complex multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidal behaviors

• Downloaded 258 times
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  • Site-wide: 89,548
  • In genetic and genomic medicine: 304
• Year to date:
  • Site-wide: 85,560
• Since beginning of last month:
  • Site-wide: 55,959

Epigenomic profiles of African American Transthyretin Val122Ile carriers reveals putatively dysregulated amyloid mechanisms

• Downloaded 257 times
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  • Site-wide: 89,802
  • In genetic and genomic medicine: 306
• Year to date:
  • Site-wide: 46,132
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  • Site-wide: 46,536

Genome-wide meta-analysis of insomnia in over 2.3 million individuals indicates involvement of specific biological pathways through gene-prioritization

• Downloaded 255 times
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  • Site-wide: 90,073
  • In psychiatry and clinical psychology: 305
• Year to date:
  • Site-wide: 21,894
• Since beginning of last month:
  • Site-wide: 16,690

Drinking and smoking polygenic risk is associated with neurodevelopmental outcomes of children and young adults independently of psychopathology and substance use.

• Downloaded 218 times
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  • Site-wide: 98,102
  • In genetic and genomic medicine: 369
• Year to date:
  • Site-wide: 41,938
• Since beginning of last month:
  • Site-wide: 70,325

Shared loci of telomere length with brain morphology, and pleiotropy in transcriptomic and epigenomic profiles of brain

• Downloaded 204 times
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  • Site-wide: 101,083
  • In genetic and genomic medicine: 388
• Year to date:
  • Site-wide: 39,020
• Since beginning of last month:
  • Site-wide: 55,577

Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder

• Downloaded 198 times
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  • Site-wide: 102,395
  • In genetic and genomic medicine: 396
• Year to date:
  • Site-wide: 53,826
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  • Site-wide: 56,805

The Addiction Genetic Factor a(g): A Unitary Genetic Vulnerability Characterizes Substance Use Disorders and Their Associations with Common Correlates

• Downloaded 197 times
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  • Site-wide: 102,674
  • In addiction medicine: 46
• Year to date:
  • Site-wide: 4,922
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  • Site-wide: 3,646

Disentangling sex differences in the shared genetic architecture of posttraumatic stress disorder, traumatic experiences, and social support with body size and composition

• Downloaded 133 times
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  • Site-wide: 115,481
  • In psychiatry and clinical psychology: 492
• Year to date:
  • Site-wide: 8,439
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  • Site-wide: 7,473

Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder

• Downloaded 110 times
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  • Site-wide: 119,737
  • In psychiatry and clinical psychology: 537
• Year to date:
  • Site-wide: 51,174
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  • Site-wide: 39,412