Author: Abraham A Palmer

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Preprints

Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use

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  • Site-wide: 918
  • In genetics: 27
• Year to date:
  • Site-wide: 52,369
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  • Site-wide: None

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

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  • Site-wide: 3,102
  • In genetics: 125
• Year to date:
  • Site-wide: 25,400
• Since beginning of last month:
  • Site-wide: 21,898

Multivariate genomic analysis of 1.5 million people identifies genes related to addiction, antisocial behavior, and health

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  • Site-wide: 5,481
  • In genetics: 262
• Year to date:
  • Site-wide: 3,056
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  • Site-wide: 2,437

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

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  • Site-wide: 7,732
  • In genetics: 370
• Year to date:
  • Site-wide: 64,543
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Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities

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  • Site-wide: 7,778
  • In genetics: 375
• Year to date:
  • Site-wide: 6,478
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  • Site-wide: 5,104

Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

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  • Site-wide: 9,072
  • In genetics: 447
• Year to date:
  • Site-wide: 46,650
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  • Site-wide: 37,202

Genetic characterization of outbred Sprague Dawley rats and utility for genome-wide association studies

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  • Site-wide: 14,753
  • In genetics: 752
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  • Site-wide: 13,272

Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry

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  • Site-wide: 15,035
  • In genetics: 772
• Year to date:
  • Site-wide: 73,997
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  • Site-wide: 54,603

Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality

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  • Site-wide: 17,879
  • In genetics: 899
• Year to date:
  • Site-wide: 23,542
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  • Site-wide: 18,574

Adapting genotyping-by-sequencing and variant calling for heterogeneous stock rats

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  • Site-wide: 18,262
  • In genetics: 919
• Year to date:
  • Site-wide: 27,104
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  • Site-wide: 20,337

Genome-wide associations reveal human-mouse genetic convergence and modifiers of myogenesis, CPNE1 and STC2

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  • Site-wide: 23,207
  • In genetics: 1,148
• Year to date:
  • Site-wide: 80,050
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  • Site-wide: None

Genome wide association analysis in a mouse advanced intercross line

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  • Site-wide: 27,005
  • In genetics: 1,345
• Year to date:
  • Site-wide: 71,053
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  • Site-wide: None

Phenome-wide investigation of health outcomes associated with genetic predisposition to loneliness

• Downloaded 793 times
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  • Site-wide: 27,437
  • In genetics: 1,363
• Year to date:
  • Site-wide: 114,356
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  • Site-wide: 80,018

Genome-wide association study in two cohorts from a multi-generational mouse advanced intercross line highlights the difficulty of replication

• Downloaded 787 times
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  • Site-wide: 27,717
  • In genetics: 1,375
• Year to date:
  • Site-wide: 64,597
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  • Site-wide: 73,490

Genome wide association study in 3,173 outbred rats identifies multiple loci for body weight, adiposity, and fasting glucose

• Downloaded 784 times
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  • Site-wide: 27,841
  • In genetics: 1,387
• Year to date:
  • Site-wide: 100,382
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Genome-wide association studies of impulsive personality traits (BIS-11 and UPPSP) and drug experimentation in up to 22,861 adult research participants

• Downloaded 740 times
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  • Site-wide: 30,153
  • In genetics: 1,492
• Year to date:
  • Site-wide: 80,520
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  • Site-wide: 61,847

Genome-wide association study of Alcohol Use Disorder Identification Test (AUDIT) scores in 20,328 research participants of European ancestry

• Downloaded 712 times
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  • Site-wide: 31,884
  • In genetics: 1,582
• Year to date:
  • Site-wide: 81,065
• Since beginning of last month:
  • Site-wide: 61,540

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

• Downloaded 633 times
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  • Site-wide: 37,268
  • In genetics: 1,816
• Year to date:
  • Site-wide: 15,387
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  • Site-wide: 6,739

Polygenic transcriptome risk scores improve portability of polygenic risk scores across ancestries

• Downloaded 579 times
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  • Site-wide: 41,743
  • In genetics: 2,000
• Year to date:
  • Site-wide: 15,288
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  • Site-wide: None

Latent Structure of Risk Perception

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  • Site-wide: 52,912
  • In neuroscience: 7,938
• Year to date:
  • Site-wide: 101,141
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  • Site-wide: 93,152

Modeling epistasis in mice and yeast using the proportion of two or more distinct genetic backgrounds: evidence for “polygenic epistasis”

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  • Site-wide: 53,823
  • In genomics: 4,156
• Year to date:
  • Site-wide: 94,028
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  • Site-wide: 95,753

Genetic risk for major depressive disorder and loneliness in gender-specific associations with coronary artery disease

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  • Site-wide: 53,894
  • In genetics: 2,558
• Year to date:
  • Site-wide: 113,470
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  • Site-wide: None

The Latent Genetic Structure of Impulsivity and its Relation to Internalizing Psychopathology

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  • Site-wide: 55,667
  • In genetics: 2,633
• Year to date:
  • Site-wide: 36,596
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  • Site-wide: 21,801

Incentive salience attribution, sensation-seeking and novelty-seeking are independent traits in a large sample of male and female heterogeneous stock rats

• Downloaded 399 times
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  • Site-wide: 63,359
  • In animal behavior and cognition: 683
• Year to date:
  • Site-wide: 123,123
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  • Site-wide: None

Social behavior and anxiety contribute to nicotine self-administration in adolescent outbred rats

• Downloaded 368 times
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  • Site-wide: 68,353
  • In animal behavior and cognition: 753
• Year to date:
  • Site-wide: 117,845
• Since beginning of last month:
  • Site-wide: 103,382

Multivariate GWAS elucidates the genetic architecture of alcohol consumption and misuse, corrects biases, and reveals novel associations with disease

• Downloaded 361 times
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  • Site-wide: 69,564
  • In genetics: 3,246
• Year to date:
  • Site-wide: 27,567
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  • Site-wide: 22,482

Content and performance of the MiniMUGA genotyping array, a new tool to improve rigor and reproducibility in mouse research

• Downloaded 338 times
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  • Site-wide: 73,442
  • In genetics: 3,432
• Year to date:
  • Site-wide: 27,893
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  • Site-wide: 32,459

Glyoxalase (GLO1) inhibition or genetic overexpression does not alter ethanol locomotor effects: implications for GLO1 as a therapeutic target in alcohol use disorders

• Downloaded 327 times
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  • Site-wide: 75,462
  • In neuroscience: 11,654
• Year to date:
  • Site-wide: 62,204
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  • Site-wide: 51,822

Polymorphic SNPs, short tandem repeats and structural variants are responsible for differential gene expression across C57BL/6 and C57BL/10 substrains

• Downloaded 244 times
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  • Site-wide: 92,544
  • In genomics: 5,727
• Year to date:
  • Site-wide: 29,711
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  • Site-wide: None

Inhibition of Glyoxalase 1 reduces alcohol self-administration in dependent and nondependent rats

• Downloaded 219 times
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  • Site-wide: 97,841
  • In neuroscience: 15,347
• Year to date:
  • Site-wide: 117,490
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  • Site-wide: 104,714

Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats.

• Downloaded 155 times
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  • Site-wide: 111,216
  • In animal behavior and cognition: 1,477
• Year to date:
  • Site-wide: 96,109
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  • Site-wide: None

Assessing the motivational effects of ethanol in mice using a discrete-trial current-intensity intracranial self-stimulation procedure

• Downloaded 140 times
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  • Site-wide: 114,280
  • In neuroscience: 17,739
• Year to date:
  • Site-wide: 123,339
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  • Site-wide: 103,050

Functional validation of a finding from a mouse genome-wide association study demonstrates that a mutant allele of Azi2 alters sensitivity to methamphetamine

• Downloaded 122 times
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  • Site-wide: 117,473
  • In animal behavior and cognition: 1,592
• Year to date:
  • Site-wide: 95,296
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  • Site-wide: 84,491

Genetic and pharmacological manipulations of glyoxalase 1 mediate ethanol withdrawal seizure susceptibility in mice

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  • Site-wide: 124,039
  • In neuroscience: 19,161
• Year to date:
  • Site-wide: 56,263
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  • Site-wide: 87,217

Analysis of independent cohorts of outbred CFW mice reveals novel loci for behavioral and physiological traits and identifies factors determining reproducibility

• Downloaded 44 times
• Download rankings, all-time:
  • Site-wide: 127,566
  • In bioinformatics: 10,099
• Year to date:
  • Site-wide: 30,222
• Since beginning of last month:
  • Site-wide: 10,827