Author: T-K Clarke

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Preprints

Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 1,126
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  • Site-wide: 14,555
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  • Site-wide: 14,555

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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  • Site-wide: 2,152
  • In genetics: 83
• Year to date:
  • Site-wide: 28,147
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  • Site-wide: 28,147

Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

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  • Site-wide: 4,830
  • In genetics: 225
• Year to date:
  • Site-wide: 67,648
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Minimal phenotyping yields GWAS hits of reduced specificity for major depression

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  • Site-wide: 6,951
  • In genetics: 341
• Year to date:
  • Site-wide: 46,258
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Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

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  • Site-wide: 7,676
  • In genetics: 369
• Year to date:
  • Site-wide: 59,260
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Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

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  • Site-wide: 9,036
  • In genetics: 448
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  • Site-wide: 48,087
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Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 11,249
  • In genomics: 1,251
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  • Site-wide: 55,489
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  • Site-wide: 55,489

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

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  • Site-wide: 12,504
  • In genetics: 633
• Year to date:
  • Site-wide: 72,565
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  • Site-wide: 72,565

Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

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  • Site-wide: 14,941
  • In genetics: 769
• Year to date:
  • Site-wide: 51,313
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  • Site-wide: 51,313

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

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  • Site-wide: 15,153
  • In genetics: 780
• Year to date:
  • Site-wide: 32,535
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  • Site-wide: 32,535

Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality

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  • Site-wide: 17,973
  • In genetics: 903
• Year to date:
  • Site-wide: 24,325
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  • Site-wide: 24,325

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

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  • Site-wide: 24,303
  • In genetics: 1,204
• Year to date:
  • Site-wide: 84,284
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  • Site-wide: 84,284

Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

• Downloaded 743 times
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  • Site-wide: 29,780
  • In genetics: 1,478
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  • Site-wide: 70,348
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Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780 000 participants

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  • Site-wide: 30,577
  • In epidemiology: 1,546
• Year to date:
  • Site-wide: 35,848
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  • Site-wide: 35,848

Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

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  • Site-wide: 30,925
  • In genetics: 1,534
• Year to date:
  • Site-wide: 100,378
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  • Site-wide: 100,378

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

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  • Site-wide: 31,702
  • In genetics: 1,575
• Year to date:
  • Site-wide: 98,873
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  • Site-wide: 98,873

Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

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  • Site-wide: 35,138
  • In genetics: 1,722
• Year to date:
  • Site-wide: 72,492
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  • Site-wide: 72,492

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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  • Site-wide: 37,044
  • In genetics: 1,809
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  • Site-wide: 13,347
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  • Site-wide: 13,347

Genetic and environmental risk for chronic pain and the contribution of risk variants for psychiatric disorders. Results from Generation Scotland: Scottish Family Health Study and UK Biobank

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  • Site-wide: 37,410
  • In genomics: 3,210
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A meta-analysis of genome-wide association studies of epigenetic age acceleration

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  • Site-wide: 42,754
  • In genetics: 2,071
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  • Site-wide: 120,972

CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake

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  • Site-wide: 45,081
  • In genetics: 2,168
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Longitudinal trajectories of brain age in young individuals at familial risk of mood disorder

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  • Site-wide: 50,731
  • In neuroscience: 7,562
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  • Site-wide: 53,441
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  • Site-wide: 53,441

Evaluating the effects of alcohol and tobacco use on cardiovascular disease using multivariable Mendelian randomization

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  • Site-wide: 52,778
  • In genomics: 4,106
• Year to date:
  • Site-wide: 96,090
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  • Site-wide: 96,090

Genome-wide by environment interaction studies (GWEIS) of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland.

• Downloaded 424 times
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  • Site-wide: 59,237
  • In genetics: 2,805
• Year to date:
  • Site-wide: 43,415
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  • Site-wide: 43,415

Epigenetic prediction of major depressive disorder

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  • Site-wide: 62,667
  • In psychiatry and clinical psychology: 186
• Year to date:
  • Site-wide: 118,681
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  • Site-wide: 118,681

Cognitive functioning and lifetime Major Depressive Disorder in UK Biobank

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  • Site-wide: 63,685
  • In psychiatry and clinical psychology: 191
• Year to date:
  • Site-wide: 64,816
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  • Site-wide: 64,816

Multivariate GWAS elucidates the genetic architecture of alcohol consumption and misuse, corrects biases, and reveals novel associations with disease

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  • Site-wide: 70,815
  • In genetics: 3,308
• Year to date:
  • Site-wide: 30,726
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  • Site-wide: 30,726

Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

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  • Site-wide: 72,401
  • In genetics: 3,377
• Year to date:
  • Site-wide: 116,414
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  • Site-wide: 116,414

Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

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  • Site-wide: 73,228
  • In genetics: 3,419
• Year to date:
  • Site-wide: 109,985
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  • Site-wide: 109,985

Epigenetic signatures of starting and stopping smoking

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  • Site-wide: 83,818
  • In genomics: 5,398
• Year to date:
  • Site-wide: 121,385
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  • Site-wide: 121,385

Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures

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  • Site-wide: 97,569
  • In neuroscience: 15,281
• Year to date:
  • Site-wide: 122,398
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  • Site-wide: 122,398

Associations between alcohol use and accelerated biological ageing

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  • Site-wide: 110,470
  • In psychiatry and clinical psychology: 445
• Year to date:
  • Site-wide: 36,621
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  • Site-wide: 36,621