Author: Hongyu Zhao

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Preprints

Androgen regulates SARS-CoV-2 receptor levels and is associated with severe COVID-19 symptoms in men

• Downloaded 4,437 times
• Download rankings, all-time:
  • Site-wide: 2,217
  • In cell biology: 40
• Year to date:
  • Site-wide: 5,555
• Since beginning of last month:
  • Site-wide: 7,063

Single-Cell Omics Reveals Dyssynchrony of the Innate and Adaptive Immune System in Progressive COVID-19

• Downloaded 3,630 times
• Download rankings, all-time:
  • Site-wide: 2,960
  • In infectious diseases: 566
• Year to date:
  • Site-wide: 3,450
• Since beginning of last month:
  • Site-wide: 6,013

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

• Downloaded 2,810 times
• Download rankings, all-time:
  • Site-wide: 4,235
  • In genomics: 488
• Year to date:
  • Site-wide: 5,835
• Since beginning of last month:
  • Site-wide: 5,050

A statistical framework for cross-tissue transcriptome-wide association analysis

• Downloaded 2,752 times
• Download rankings, all-time:
  • Site-wide: 4,354
  • In genetics: 199
• Year to date:
  • Site-wide: 42,768
• Since beginning of last month:
  • Site-wide: 40,554

AC-PCA: simultaneous dimension reduction and adjustment for confounding variation

• Downloaded 2,539 times
• Download rankings, all-time:
  • Site-wide: 4,925
  • In bioinformatics: 556
• Year to date:
  • Site-wide: 34,950
• Since beginning of last month:
  • Site-wide: 31,804

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

• Downloaded 1,867 times
• Download rankings, all-time:
  • Site-wide: 7,738
  • In genetics: 369
• Year to date:
  • Site-wide: 66,234
• Since beginning of last month:
  • Site-wide: 70,400

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

• Downloaded 1,664 times
• Download rankings, all-time:
  • Site-wide: 9,265
  • In genetics: 457
• Year to date:
  • Site-wide: 17,651
• Since beginning of last month:
  • Site-wide: 16,755

A powerful approach to estimating annotation-stratified genetic covariance using GWAS summary statistics

• Downloaded 1,584 times
• Download rankings, all-time:
  • Site-wide: 9,957
  • In genetics: 500
• Year to date:
  • Site-wide: 64,290
• Since beginning of last month:
  • Site-wide: 40,099

Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer's disease

• Downloaded 1,302 times
• Download rankings, all-time:
  • Site-wide: 13,290
  • In genetics: 670
• Year to date:
  • Site-wide: 99,821
• Since beginning of last month:
  • Site-wide: 84,679

Local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits

• Downloaded 1,237 times
• Download rankings, all-time:
  • Site-wide: 14,385
  • In genetics: 736
• Year to date:
  • Site-wide: 17,580
• Since beginning of last month:
  • Site-wide: None

SCRIBE: a new approach to dropout imputation and batch effects correction for single-cell RNA-seq data

• Downloaded 1,077 times
• Download rankings, all-time:
  • Site-wide: 17,689
  • In bioinformatics: 2,151
• Year to date:
  • Site-wide: 31,957
• Since beginning of last month:
  • Site-wide: 36,600

Genomic Characterization of Posttraumatic Stress Disorder in a Large US Military Veteran Sample

• Downloaded 1,015 times
• Download rankings, all-time:
  • Site-wide: 19,369
  • In genetics: 962
• Year to date:
  • Site-wide: 7,958
• Since beginning of last month:
  • Site-wide: 6,066

A reservoir of stem-like CD8 T cells in the tumor-draining lymph node maintains the ongoing anti-tumor immune response

• Downloaded 1,006 times
• Download rankings, all-time:
  • Site-wide: 19,640
  • In immunology: 546
• Year to date:
  • Site-wide: 550
• Since beginning of last month:
  • Site-wide: 630

Leveraging functional annotation to identify genes associated with complex diseases

• Downloaded 955 times
• Download rankings, all-time:
  • Site-wide: 21,103
  • In genetics: 1,038
• Year to date:
  • Site-wide: 48,127
• Since beginning of last month:
  • Site-wide: 68,529

Mediated pleiotropy between psychiatric disorders and autoimmune disorders revealed by integrative analysis of multiple GWAS

• Downloaded 949 times
• Download rankings, all-time:
  • Site-wide: 21,280
  • In genomics: 2,130
• Year to date:
  • Site-wide: 82,349
• Since beginning of last month:
  • Site-wide: 55,401

Neoantigen-driven B cell and CD4+ T follicular helper cell collaboration promotes robust anti-tumor CD8+ T cell responses

• Downloaded 841 times
• Download rankings, all-time:
  • Site-wide: 25,354
  • In immunology: 709
• Year to date:
  • Site-wide: 2,119
• Since beginning of last month:
  • Site-wide: None

Measuring genetic variation in the multi-ethnic Million Veteran Program (MVP)

• Downloaded 829 times
• Download rankings, all-time:
  • Site-wide: 25,862
  • In genetics: 1,279
• Year to date:
  • Site-wide: 38,177
• Since beginning of last month:
  • Site-wide: None

Genome-wide Association Study of Alcohol Consumption and Use Disorder in Multiple Populations (N = 274,424)

• Downloaded 827 times
• Download rankings, all-time:
  • Site-wide: 25,930
  • In genetics: 1,283
• Year to date:
  • Site-wide: 100,876
• Since beginning of last month:
  • Site-wide: None

Leveraging Functional Annotations in Genetic Risk Prediction for Human Complex Diseases

• Downloaded 730 times
• Download rankings, all-time:
  • Site-wide: 30,845
  • In bioinformatics: 3,512
• Year to date:
  • Site-wide: 114,520
• Since beginning of last month:
  • Site-wide: 77,667

Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer

• Downloaded 683 times
• Download rankings, all-time:
  • Site-wide: 33,829
  • In genetic and genomic medicine: 97
• Year to date:
  • Site-wide: 5,288
• Since beginning of last month:
  • Site-wide: 10,189

Transcriptomic Organization of Human Posttraumatic Stress Disorder

• Downloaded 668 times
• Download rankings, all-time:
  • Site-wide: 34,802
  • In genomics: 3,053
• Year to date:
  • Site-wide: 34,065
• Since beginning of last month:
  • Site-wide: None

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

• Downloaded 633 times
• Download rankings, all-time:
  • Site-wide: 37,338
  • In genetics: 1,816
• Year to date:
  • Site-wide: 16,169
• Since beginning of last month:
  • Site-wide: 7,719

Three distinct velocities of elongating RNA polymerase define exons and introns

• Downloaded 607 times
• Download rankings, all-time:
  • Site-wide: 39,362
  • In genomics: 3,323
• Year to date:
  • Site-wide: 95,770
• Since beginning of last month:
  • Site-wide: 54,995

Influence of blood pressure on pneumonia risk: Epidemiological association and Mendelian randomisation in the UK Biobank

• Downloaded 561 times
• Download rankings, all-time:
  • Site-wide: 43,449
  • In genetic and genomic medicine: 120
• Year to date:
  • Site-wide: 70,485
• Since beginning of last month:
  • Site-wide: 73,213

Identifying Combinations of Cancer Drivers in Individual Patients

• Downloaded 530 times
• Download rankings, all-time:
  • Site-wide: 46,605
  • In bioinformatics: 4,918
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

Genetic Association of Arterial Stiffness Index with Blood Pressure and Coronary Artery Disease

• Downloaded 518 times
• Download rankings, all-time:
  • Site-wide: 47,814
  • In bioinformatics: 5,016
• Year to date:
  • Site-wide: 57,274
• Since beginning of last month:
  • Site-wide: 81,449

Comparison of methods for estimating genetic correlation between complex traits using GWAS summary statistics

• Downloaded 450 times
• Download rankings, all-time:
  • Site-wide: 56,049
  • In genetics: 2,652
• Year to date:
  • Site-wide: 14,401
• Since beginning of last month:
  • Site-wide: 13,858

Application of a Novel Machine Learning Method to Big Data Infers a Relationship Between Asthma and the Development of Neoplasia

• Downloaded 399 times
• Download rankings, all-time:
  • Site-wide: 63,518
  • In epidemiology: 2,684
• Year to date:
  • Site-wide: 89,671
• Since beginning of last month:
  • Site-wide: None

Genomic Influences on Self-Reported Childhood Maltreatment

• Downloaded 373 times
• Download rankings, all-time:
  • Site-wide: 67,642
  • In genomics: 4,775
• Year to date:
  • Site-wide: 108,356
• Since beginning of last month:
  • Site-wide: 84,380

microRNA seedless sites attenuate strong-seed-site-mediated target repression

• Downloaded 333 times
• Download rankings, all-time:
  • Site-wide: 74,517
  • In bioinformatics: 6,965
• Year to date:
  • Site-wide: 63,140
• Since beginning of last month:
  • Site-wide: 78,069

Retrospective Association Analysis of Longitudinal Binary Traits Identifies Important Loci and Pathways in Cocaine Use

• Downloaded 326 times
• Download rankings, all-time:
  • Site-wide: 75,800
  • In genetics: 3,522
• Year to date:
  • Site-wide: 60,556
• Since beginning of last month:
  • Site-wide: 62,726

Circadian Rhythm Analysis Using Wearable Device Data: A Novel Penalized Machine Learning Approach

• Downloaded 319 times
• Download rankings, all-time:
  • Site-wide: 77,138
  • In neuroscience: 11,919
• Year to date:
  • Site-wide: 34,108
• Since beginning of last month:
  • Site-wide: 59,754

Motor nuclei innervating eye muscles spared in mouse model of SOD1-linked ALS

• Downloaded 286 times
• Download rankings, all-time:
  • Site-wide: 83,782
  • In neuroscience: 12,982
• Year to date:
  • Site-wide: 90,672
• Since beginning of last month:
  • Site-wide: 83,959

Identifying Modules of Cooperating Cancer Drivers

• Downloaded 254 times
• Download rankings, all-time:
  • Site-wide: 90,690
  • In cancer biology: 2,743
• Year to date:
  • Site-wide: 63,573
• Since beginning of last month:
  • Site-wide: 103,685

TRPV5, TRPV6, TRPM6, and TRPM7 do not contribute to hair-cell mechanotransduction

• Downloaded 247 times
• Download rankings, all-time:
  • Site-wide: 92,151
  • In neuroscience: 14,421
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

A fast and robust Bayesian nonparametric method for prediction of complex traits using summary statistics

• Downloaded 179 times
• Download rankings, all-time:
  • Site-wide: 106,707
  • In bioinformatics: 9,012
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

A Markov Random Field Model for Network-based Differential Expression Analysis of Single-cell RNA-seq Data

• Downloaded 179 times
• Download rankings, all-time:
  • Site-wide: 106,783
  • In bioinformatics: 9,010
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

Automated Feature Extraction from Population Wearable Device Data Identified Novel Loci Associated with Sleep and Circadian Rhythms

• Downloaded 168 times
• Download rankings, all-time:
  • Site-wide: 108,967
  • In genetics: 4,820
• Year to date:
  • Site-wide: 97,373
• Since beginning of last month:
  • Site-wide: None

Inferring time-lagged causality using the derivative of single-cell expression

• Downloaded 133 times
• Download rankings, all-time:
  • Site-wide: 115,884
  • In bioinformatics: 9,511
• Year to date:
  • Site-wide: 8,875
• Since beginning of last month:
  • Site-wide: 2,931

Correcting statistical bias in correlation-based kinship estimators

• Downloaded 94 times
• Download rankings, all-time:
  • Site-wide: 123,077
  • In genetics: 5,241
• Year to date:
  • Site-wide: 13,809
• Since beginning of last month:
  • Site-wide: 44,216

A Statistical Framework to Identify Cell Types Whose Genetically Regulated Proportions are Associated with Complex Diseases

• Downloaded 31 times
• Download rankings, all-time:
  • Site-wide: 129,476
  • In genetic and genomic medicine: 612
• Year to date:
  • Site-wide: 44,811
• Since beginning of last month:
  • Site-wide: 17,442

Comprehensive Analysis of Ubiquitously Expressed Genes in Human, From a Data-Driven Perspective

• Downloaded 22 times
• Download rankings, all-time:
  • Site-wide: 129,793
  • In genomics: 6,816
• Year to date:
  • Site-wide: 61,155
• Since beginning of last month:
  • Site-wide: 24,951