Author: Michael J Owen

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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Genomewide association study identifies 30 loci associated with bipolar disorder

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Genetic Identification Of Brain Cell Types Underlying Schizophrenia

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Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

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Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection

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Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits

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A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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Genome-wide association study of over 40,000 bipolar disorder cases provides novel biological insights

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Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

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Causal Analyses, Statistical Efficiency And Phenotypic Precision Through Recall-By-Genotype Study Design

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Medical consequences of pathogenic CNVs in adults: Analysis of the UK Biobank

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Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders

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Rare schizophrenia risk variants are enriched in genes shared with neurodevelopmental disorders

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Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

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Genetic association study of psychotic experiences in UK Biobank

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A Genetics-First Approach to Dissecting the Heterogeneity of Autism: Phenotypic Comparison of Autism Risk Copy Number Variants

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Association between schizophrenia and both loss of function and missense mutations in paralog conserved sites of voltage-gated sodium channels

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Psychosis and the level of mood incongruence in Bipolar Disorder are related to genetic liability for Schizophrenia

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Different complement immune pathways mediate innate and learned aversion

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Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

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A Transcriptome Wide Association Study implicates specific pre- and post-synaptic abnormalities in Schizophrenia

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Synaptic protein DLG2 controls neurogenic transcriptional programs disrupted in schizophrenia and related disorders

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Analyses of rare and common alleles in parent-proband trios implicate rare missense variants in SLC6A1 in schizophrenia and confirm the involvement of loss of function intolerant and neurodevelopmental disorder genes.

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Genetic association of FMRP targets with psychiatric disorders

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The general impact of haploinsufficiency on brain connectivity underlies the pleiotropic effect of neuropsychiatric CNVs

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Schizophrenia, autism spectrum disorders and developmental disorders share specific disruptive coding mutations

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Haploinsufficiency of the psychiatric risk gene Cyfip1 causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanisms

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Dynamic expression of risk genes for schizophrenia and bipolar disorder across development

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The role of rare copy number variants in depression

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Effects of pathogenic CNVs on physical traits in participants of the UK Biobank

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Meta-analysis of Scandinavian Schizophrenia Exomes

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Cyfip1 haploinsufficiency is associated with white matter changes, myelin thinning, reduction of mature oligodendrocytes and behavioural inflexibility

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Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

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Neuropsychiatric copy number variants exert shared effects on human brain structure

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Novel Insight into the Aetiology of Autism Spectrum Disorder Gained by Integrating Expression Data with Genome-wide Association Statistics

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Differences in Genetic Liability for Insomnia and Hypersomnia in Bipolar Disorder Subtypes

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The rate of de novo CNVs in healthy controls

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Electrophysiological network alterations in adults with copy number variants associated with high neurodevelopmental risk

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Effects of pathogenic CNVs on biochemical markers: a study on the UK Biobank

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Emotional and behavioural phenotypes in young people with neurodevelopmental CNVs

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A brief report: de novo copy number variants in children with attention deficit hyperactivity disorder

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Coordination difficulties, IQ and psychopathology in children with high-risk Copy Number Variants

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Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by mutation of the psychiatric risk gene Cacna1c

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Developmental profile of psychiatric risk associated with voltage-gated cation channel activity

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Psychopathology in mothers of children with pathogenic Copy Number Variants

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Clozapine metabolism is associated with Absolute Neutrophil Count in individuals with treatment-resistant schizophrenia

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