Author: Philippe Amouyel

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Preprints

The Genetic History of France

• Downloaded 4,708 times
• Download rankings, all-time:
  • Site-wide: 2,024
  • In genetics: 75
• Year to date:
  • Site-wide: 15,530
• Since beginning of last month:
  • Site-wide: None

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

• Downloaded 3,247 times
• Download rankings, all-time:
  • Site-wide: 3,471
  • In genetics: 149
• Year to date:
  • Site-wide: 26,115
• Since beginning of last month:
  • Site-wide: 26,158

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,069 times
• Download rankings, all-time:
  • Site-wide: 3,747
  • In genetics: 167
• Year to date:
  • Site-wide: 39,415
• Since beginning of last month:
  • Site-wide: 51,372

New insights on the genetic etiology of Alzheimer and related dementia

• Downloaded 2,373 times
• Download rankings, all-time:
  • Site-wide: 5,442
  • In neurology: 11
• Year to date:
  • Site-wide: 1,010
• Since beginning of last month:
  • Site-wide: 891

Common variants in Alzheimer's disease: Novel association of six genetic variants with AD and risk stratification by polygenic risk scores

• Downloaded 2,349 times
• Download rankings, all-time:
  • Site-wide: 5,529
  • In genetic and genomic medicine: 15
• Year to date:
  • Site-wide: 9,282
• Since beginning of last month:
  • Site-wide: 10,545

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

• Downloaded 1,826 times
• Download rankings, all-time:
  • Site-wide: 7,967
  • In neuroscience: 840
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,826 times
• Download rankings, all-time:
  • Site-wide: 7,969
  • In genetics: 387
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

• Downloaded 1,700 times
• Download rankings, all-time:
  • Site-wide: 8,933
  • In genetics: 442
• Year to date:
  • Site-wide: 99,510
• Since beginning of last month:
  • Site-wide: None

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,637 times
• Download rankings, all-time:
  • Site-wide: 9,448
  • In genetics: 464
• Year to date:
  • Site-wide: 80,032
• Since beginning of last month:
  • Site-wide: 77,425

Exome sequencing identifies novel AD-associated genes.

• Downloaded 1,010 times
• Download rankings, all-time:
  • Site-wide: 19,442
  • In genetic and genomic medicine: 59
• Year to date:
  • Site-wide: 8,760
• Since beginning of last month:
  • Site-wide: 9,201

ACE inhibitors, AT1 receptor blockers and COVID-19: clinical epidemiology evidences for a continuation of treatments. The ACER-COVID study

• Downloaded 876 times
• Download rankings, all-time:
  • Site-wide: 23,810
  • In cardiovascular medicine: 36
• Year to date:
  • Site-wide: 51,368
• Since beginning of last month:
  • Site-wide: 49,215

Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants

• Downloaded 741 times
• Download rankings, all-time:
  • Site-wide: 30,062
  • In genetics: 1,487
• Year to date:
  • Site-wide: 16,220
• Since beginning of last month:
  • Site-wide: 29,571

Genetic determinants of risk and survival in pulmonary arterial hypertension

• Downloaded 664 times
• Download rankings, all-time:
  • Site-wide: 34,928
  • In genetics: 1,710
• Year to date:
  • Site-wide: 63,290
• Since beginning of last month:
  • Site-wide: 88,737

Alzheimer’s genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner

• Downloaded 626 times
• Download rankings, all-time:
  • Site-wide: 37,706
  • In pathology: 162
• Year to date:
  • Site-wide: 41,164
• Since beginning of last month:
  • Site-wide: 25,468

Pyk2 Overexpression in Postsynaptic Neurons Blocks Aβ1-42-induced Synaptotoxicity in a Microfluidic Co-Culture Model

• Downloaded 500 times
• Download rankings, all-time:
  • Site-wide: 49,773
  • In neuroscience: 7,389
• Year to date:
  • Site-wide: 34,172
• Since beginning of last month:
  • Site-wide: 46,310

BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation

• Downloaded 456 times
• Download rankings, all-time:
  • Site-wide: 55,140
  • In neuroscience: 8,268
• Year to date:
  • Site-wide: 84,292
• Since beginning of last month:
  • Site-wide: 76,924

Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

• Downloaded 429 times
• Download rankings, all-time:
  • Site-wide: 58,795
  • In neuroscience: 8,924
• Year to date:
  • Site-wide: 96,950
• Since beginning of last month:
  • Site-wide: 105,518

Identification of hippocampal volume as a mediator of the association between APOE4 and dementia

• Downloaded 153 times
• Download rankings, all-time:
  • Site-wide: 111,421
  • In epidemiology: 4,536
• Year to date:
  • Site-wide: 48,458
• Since beginning of last month:
  • Site-wide: 91,832

Restore mitophagy is essential to prevent cardiac oxidative stress during hypertrophy

• Downloaded 59 times
• Download rankings, all-time:
  • Site-wide: 126,640
  • In cell biology: 5,803
• Year to date:
  • Site-wide: 21,630
• Since beginning of last month:
  • Site-wide: None