Author: Mohammad Arfan Ikram

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Preprints

The genetic architecture of the human cerebral cortex

• Downloaded 7,906 times
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  • Site-wide: 1,005
  • In genetics: 30
• Year to date:
  • Site-wide: 16,284
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  • Site-wide: None

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

• Downloaded 5,134 times
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  • Site-wide: 1,787
  • In genetics: 68
• Year to date:
  • Site-wide: 25,179
• Since beginning of last month:
  • Site-wide: None

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

• Downloaded 3,247 times
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  • Site-wide: 3,460
  • In genetics: 148
• Year to date:
  • Site-wide: 25,028
• Since beginning of last month:
  • Site-wide: 23,704

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

• Downloaded 3,223 times
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  • Site-wide: 3,496
  • In genomics: 397
• Year to date:
  • Site-wide: 66,987
• Since beginning of last month:
  • Site-wide: 47,002

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

• Downloaded 2,501 times
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  • Site-wide: 5,018
  • In genetics: 231
• Year to date:
  • Site-wide: 71,319
• Since beginning of last month:
  • Site-wide: 74,333

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

• Downloaded 1,826 times
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  • Site-wide: 7,953
  • In neuroscience: 838
• Year to date:
  • Site-wide: None
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  • Site-wide: None

Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

• Downloaded 1,737 times
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  • Site-wide: 8,596
  • In genetics: 420
• Year to date:
  • Site-wide: 61,050
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  • Site-wide: 41,196

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

• Downloaded 1,700 times
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  • Site-wide: 8,901
  • In genetics: 442
• Year to date:
  • Site-wide: 97,735
• Since beginning of last month:
  • Site-wide: None

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,637 times
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  • Site-wide: 9,430
  • In genetics: 464
• Year to date:
  • Site-wide: 76,010
• Since beginning of last month:
  • Site-wide: 75,008

Equivalence of LD-Score Regression and Individual-Level-Data Methods

• Downloaded 1,462 times
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  • Site-wide: 11,098
  • In genetics: 553
• Year to date:
  • Site-wide: 21,093
• Since beginning of last month:
  • Site-wide: 12,760

Grey Matter Age Prediction as a Biomarker for Risk of Dementia: A Population-based Study

• Downloaded 1,323 times
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  • Site-wide: 12,897
  • In epidemiology: 854
• Year to date:
  • Site-wide: 36,331
• Since beginning of last month:
  • Site-wide: 30,536

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

• Downloaded 1,288 times
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  • Site-wide: 13,427
  • In genomics: 1,460
• Year to date:
  • Site-wide: 15,084
• Since beginning of last month:
  • Site-wide: 10,972

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,240 times
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  • Site-wide: 14,210
  • In genomics: 1,513
• Year to date:
  • Site-wide: 54,719
• Since beginning of last month:
  • Site-wide: 41,189

Exome sequencing identifies novel AD-associated genes.

• Downloaded 1,010 times
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  • Site-wide: 19,396
  • In genetic and genomic medicine: 59
• Year to date:
  • Site-wide: 8,363
• Since beginning of last month:
  • Site-wide: 8,193

Planar cell polarity pathway and development of the human visual cortex

• Downloaded 757 times
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  • Site-wide: 29,145
  • In neuroscience: 3,987
• Year to date:
  • Site-wide: 43,216
• Since beginning of last month:
  • Site-wide: 51,421

Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants

• Downloaded 741 times
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  • Site-wide: 30,008
  • In genetics: 1,487
• Year to date:
  • Site-wide: 15,413
• Since beginning of last month:
  • Site-wide: 27,094

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 711 times
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  • Site-wide: 31,775
  • In genetics: 1,578
• Year to date:
  • Site-wide: 14,335
• Since beginning of last month:
  • Site-wide: 10,256

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

• Downloaded 709 times
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  • Site-wide: 31,912
  • In bioinformatics: 3,622
• Year to date:
  • Site-wide: None
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  • Site-wide: None

GenNet framework: interpretable neural networks for phenotype prediction

• Downloaded 693 times
• Download rankings, all-time:
  • Site-wide: 32,920
  • In bioinformatics: 3,731
• Year to date:
  • Site-wide: 4,937
• Since beginning of last month:
  • Site-wide: 7,426

Relationship between gut microbiota and circulating metabolites in population-based cohorts

• Downloaded 688 times
• Download rankings, all-time:
  • Site-wide: 33,256
  • In epidemiology: 1,627
• Year to date:
  • Site-wide: 115,786
• Since beginning of last month:
  • Site-wide: 90,034

Novel genetic loci affecting facial shape variation in humans

• Downloaded 672 times
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  • Site-wide: 34,298
  • In genomics: 3,017
• Year to date:
  • Site-wide: 66,995
• Since beginning of last month:
  • Site-wide: 76,017

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 602 times
• Download rankings, all-time:
  • Site-wide: 39,536
  • In genetic and genomic medicine: 113
• Year to date:
  • Site-wide: 7,852
• Since beginning of last month:
  • Site-wide: 10,843

Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference

• Downloaded 517 times
• Download rankings, all-time:
  • Site-wide: 47,618
  • In genomics: 3,822
• Year to date:
  • Site-wide: 65,666
• Since beginning of last month:
  • Site-wide: 77,148

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 501 times
• Download rankings, all-time:
  • Site-wide: 49,473
  • In genomics: 3,916
• Year to date:
  • Site-wide: 107,853
• Since beginning of last month:
  • Site-wide: 95,163

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 474 times
• Download rankings, all-time:
  • Site-wide: 52,696
  • In genetics: 2,503
• Year to date:
  • Site-wide: 88,353
• Since beginning of last month:
  • Site-wide: 74,694

High-dimensional mapping of cognition to the brain using voxel-based morphometry and subcortical shape analysis.

• Downloaded 337 times
• Download rankings, all-time:
  • Site-wide: 73,451
  • In neuroscience: 11,317
• Year to date:
  • Site-wide: 95,874
• Since beginning of last month:
  • Site-wide: 81,134

Genetic variants for head size share genes and pathways with cancer

• Downloaded 334 times
• Download rankings, all-time:
  • Site-wide: 73,833
  • In genomics: 5,030
• Year to date:
  • Site-wide: 42,173
• Since beginning of last month:
  • Site-wide: 56,723

Correction for both common and rare cell types in blood is important to identify genes that correlate with age

• Downloaded 274 times
• Download rankings, all-time:
  • Site-wide: 85,574
  • In bioinformatics: 7,691
• Year to date:
  • Site-wide: 74,789
• Since beginning of last month:
  • Site-wide: 69,634

KCND3 is a novel susceptibility locus for early repolarization

• Downloaded 247 times
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  • Site-wide: 91,608
  • In genetics: 4,176
• Year to date:
  • Site-wide: 117,775
• Since beginning of last month:
  • Site-wide: 104,543

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 199 times
• Download rankings, all-time:
  • Site-wide: 101,916
  • In genomics: 6,014
• Year to date:
  • Site-wide: 99,026
• Since beginning of last month:
  • Site-wide: 100,787

Investigating the relationships between unfavorable sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses

• Downloaded 131 times
• Download rankings, all-time:
  • Site-wide: 115,319
  • In epidemiology: 4,671
• Year to date:
  • Site-wide: 53,333
• Since beginning of last month:
  • Site-wide: 56,477