Author: Wei Zhao

Downloads per author, site-wide

Preprints

Heterogeneity in polygenic scores for common human traits

• Downloaded 3,622 times
• Download rankings, all-time:
  • Site-wide: 2,960
  • In genetics: 118
• Year to date:
  • Site-wide: 15,789
• Since beginning of last month:
  • Site-wide: 11,121

AI-assisted CT imaging analysis for COVID-19 screening: Building and deploying a medical AI system in four weeks

• Downloaded 3,306 times
• Download rankings, all-time:
  • Site-wide: 3,373
  • In health informatics: 20
• Year to date:
  • Site-wide: 6,532
• Since beginning of last month:
  • Site-wide: 6,145

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

• Downloaded 3,247 times
• Download rankings, all-time:
  • Site-wide: 3,480
  • In genetics: 149
• Year to date:
  • Site-wide: 27,041
• Since beginning of last month:
  • Site-wide: 29,233

PARPi triggers STING-dependent immune response and enhances therapeutic efficacy of immune checkpoint blockade independent of BRCAness

• Downloaded 2,571 times
• Download rankings, all-time:
  • Site-wide: 4,825
  • In cancer biology: 71
• Year to date:
  • Site-wide: 19,631
• Since beginning of last month:
  • Site-wide: 17,293

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

• Downloaded 2,088 times
• Download rankings, all-time:
  • Site-wide: 6,543
  • In genomics: 742
• Year to date:
  • Site-wide: 113,485
• Since beginning of last month:
  • Site-wide: 96,268

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,826 times
• Download rankings, all-time:
  • Site-wide: 7,985
  • In genetics: 387
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

Cell atlas of human uterus

• Downloaded 1,717 times
• Download rankings, all-time:
  • Site-wide: 8,801
  • In cell biology: 216
• Year to date:
  • Site-wide: 18,554
• Since beginning of last month:
  • Site-wide: 26,303

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

• Downloaded 1,704 times
• Download rankings, all-time:
  • Site-wide: 8,920
  • In genetics: 440
• Year to date:
  • Site-wide: 58,668
• Since beginning of last month:
  • Site-wide: 61,399

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,637 times
• Download rankings, all-time:
  • Site-wide: 9,474
  • In genetics: 467
• Year to date:
  • Site-wide: 81,000
• Since beginning of last month:
  • Site-wide: 80,984

Empirical determinants of adaptive mutations in yeast experimental evolution

• Downloaded 1,481 times
• Download rankings, all-time:
  • Site-wide: 10,935
  • In genomics: 1,214
• Year to date:
  • Site-wide: 62,416
• Since beginning of last month:
  • Site-wide: 44,189

Induced Pluripotent Stem Cell-derived CAR-Macrophage Cells with Antigen-dependent Anti-Cancer Cell Functions for Liquid and Solid Tumors

• Downloaded 1,427 times
• Download rankings, all-time:
  • Site-wide: 11,578
  • In cell biology: 318
• Year to date:
  • Site-wide: 5,003
• Since beginning of last month:
  • Site-wide: 5,225

Novel genetic determinants of telomere length from a trans-ethnic analysis of 109,122 whole genome sequences in TOPMed

• Downloaded 1,315 times
• Download rankings, all-time:
  • Site-wide: 13,084
  • In genetics: 662
• Year to date:
  • Site-wide: 8,426
• Since beginning of last month:
  • Site-wide: 8,671

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

• Downloaded 1,187 times
• Download rankings, all-time:
  • Site-wide: 15,274
  • In genetics: 783
• Year to date:
  • Site-wide: 35,957
• Since beginning of last month:
  • Site-wide: 33,705

The genomic and epigenomic evolutionary history of papillary renal cell carcinomas

• Downloaded 1,126 times
• Download rankings, all-time:
  • Site-wide: 16,558
  • In genomics: 1,739
• Year to date:
  • Site-wide: 28,833
• Since beginning of last month:
  • Site-wide: 34,099

Bromodomain and Extraterminal Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection (Pre-Clinical)

• Downloaded 1,087 times
• Download rankings, all-time:
  • Site-wide: 17,444
  • In cell biology: 571
• Year to date:
  • Site-wide: 4,346
• Since beginning of last month:
  • Site-wide: 2,085

Clinical features and management of severe COVID-19: A retrospective study in Wuxi, Jiangsu Province, China

• Downloaded 1,083 times
• Download rankings, all-time:
  • Site-wide: 17,532
  • In infectious diseases: 1,511
• Year to date:
  • Site-wide: 39,790
• Since beginning of last month:
  • Site-wide: 40,538

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

• Downloaded 1,054 times
• Download rankings, all-time:
  • Site-wide: 18,239
  • In genetics: 918
• Year to date:
  • Site-wide: 5,449
• Since beginning of last month:
  • Site-wide: 4,491

Collection of continuous rotation MicroED Data from Ion Beam Milled Crystals of Any Size

• Downloaded 1,014 times
• Download rankings, all-time:
  • Site-wide: 19,364
  • In biochemistry: 407
• Year to date:
  • Site-wide: 121,727
• Since beginning of last month:
  • Site-wide: None

Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals

• Downloaded 1,000 times
• Download rankings, all-time:
  • Site-wide: 19,732
  • In biophysics: 533
• Year to date:
  • Site-wide: 27,282
• Since beginning of last month:
  • Site-wide: 27,028

Large-scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines

• Downloaded 808 times
• Download rankings, all-time:
  • Site-wide: 26,714
  • In systems biology: 584
• Year to date:
  • Site-wide: 24,309
• Since beginning of last month:
  • Site-wide: None

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 798 times
• Download rankings, all-time:
  • Site-wide: 27,205
  • In genetics: 1,352
• Year to date:
  • Site-wide: 27,377
• Since beginning of last month:
  • Site-wide: 52,277

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 711 times
• Download rankings, all-time:
  • Site-wide: 31,976
  • In genetics: 1,590
• Year to date:
  • Site-wide: 15,652
• Since beginning of last month:
  • Site-wide: 12,756

Uterine progesterone signaling is a target for metformin therapy in PCOS-like rats

• Downloaded 627 times
• Download rankings, all-time:
  • Site-wide: 37,729
  • In physiology: 189
• Year to date:
  • Site-wide: 74,509
• Since beginning of last month:
  • Site-wide: None

Bayesian Shrinkage Estimation of High Dimensional Causal Mediation Effects in Omics Studies

• Downloaded 599 times
• Download rankings, all-time:
  • Site-wide: 40,001
  • In epidemiology: 1,897
• Year to date:
  • Site-wide: 117,398
• Since beginning of last month:
  • Site-wide: None

Exome chip meta-analysis elucidates the genetic architecture of rare coding variants in smoking and drinking behavior

• Downloaded 570 times
• Download rankings, all-time:
  • Site-wide: 42,500
  • In genetics: 2,042
• Year to date:
  • Site-wide: 111,549
• Since beginning of last month:
  • Site-wide: None

Development of a quantum-dot lateral flow immunoassay strip based portable fluorescence smart-phone system for ultrasensitive detection of IgM/IgG to SARS-CoV-2

• Downloaded 528 times
• Download rankings, all-time:
  • Site-wide: 46,767
  • In infectious diseases: 2,439
• Year to date:
  • Site-wide: 19,093
• Since beginning of last month:
  • Site-wide: 16,654

CellGPS: Whole-body tracking of single cells by positron emission tomography

• Downloaded 511 times
• Download rankings, all-time:
  • Site-wide: 48,495
  • In bioengineering: 886
• Year to date:
  • Site-wide: 96,445
• Since beginning of last month:
  • Site-wide: None

Genetic insights into the biological mechanisms governing human ovarian ageing

• Downloaded 470 times
• Download rankings, all-time:
  • Site-wide: 53,413
  • In sexual and reproductive health: 20
• Year to date:
  • Site-wide: 1,439
• Since beginning of last month:
  • Site-wide: 1,766

A circuit of protein-protein regulatory interactions enables polarity establishment in a bacterium

• Downloaded 461 times
• Download rankings, all-time:
  • Site-wide: 54,561
  • In microbiology: 3,545
• Year to date:
  • Site-wide: 73,322
• Since beginning of last month:
  • Site-wide: 79,298

Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance

• Downloaded 456 times
• Download rankings, all-time:
  • Site-wide: 55,253
  • In microbiology: 3,598
• Year to date:
  • Site-wide: 9,815
• Since beginning of last month:
  • Site-wide: 9,288

A viral genome packaging motor transitions between cyclic and helical symmetry to translocate dsDNA

• Downloaded 444 times
• Download rankings, all-time:
  • Site-wide: 56,855
  • In biophysics: 2,006
• Year to date:
  • Site-wide: 69,884
• Since beginning of last month:
  • Site-wide: None

Qualitative analyses of polishing and pre-coating FIB milled crystals for MicroED

• Downloaded 375 times
• Download rankings, all-time:
  • Site-wide: 67,118
  • In biochemistry: 1,841
• Year to date:
  • Site-wide: 110,316
• Since beginning of last month:
  • Site-wide: 76,481

Multiplexed targeted resequencing identifies coding and regulatory variation underlying phenotypic extremes of HDL-cholesterol in humans

• Downloaded 354 times
• Download rankings, all-time:
  • Site-wide: 70,664
  • In genomics: 4,915
• Year to date:
  • Site-wide: 111,711
• Since beginning of last month:
  • Site-wide: 73,351

SCOAT-Net: A Novel Network for Segmenting COVID-19 Lung Opacification from CT Images

• Downloaded 353 times
• Download rankings, all-time:
  • Site-wide: 70,880
  • In radiology and imaging: 99
• Year to date:
  • Site-wide: 35,138
• Since beginning of last month:
  • Site-wide: 57,076

SMARCAD1 Mediated Active Replication Fork Stability Maintains Genome Integrity

• Downloaded 316 times
• Download rankings, all-time:
  • Site-wide: 77,642
  • In cell biology: 3,604
• Year to date:
  • Site-wide: 21,040
• Since beginning of last month:
  • Site-wide: 13,499

Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

• Downloaded 290 times
• Download rankings, all-time:
  • Site-wide: 82,801
  • In epidemiology: 3,389
• Year to date:
  • Site-wide: 66,783
• Since beginning of last month:
  • Site-wide: 53,549

Association of mitochondrial DNA copy number with cardiometabolic diseases in a large cross-sectional study of multiple ancestries

• Downloaded 277 times
• Download rankings, all-time:
  • Site-wide: 85,426
  • In epidemiology: 3,499
• Year to date:
  • Site-wide: 26,885
• Since beginning of last month:
  • Site-wide: 18,164

Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes: Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 271 times
• Download rankings, all-time:
  • Site-wide: 86,810
  • In genetic and genomic medicine: 293
• Year to date:
  • Site-wide: 22,504
• Since beginning of last month:
  • Site-wide: 21,172

Zinc Sulfide-Based Hybrid Exosome-Coated Nanoplatform for Targeted Treatment of Glioblastoma in an Orthotopic Mouse Glioblastoma Model

• Downloaded 255 times
• Download rankings, all-time:
  • Site-wide: 90,286
  • In pharmacology and toxicology: 628
• Year to date:
  • Site-wide: 40,303
• Since beginning of last month:
  • Site-wide: None

Auditory attention reduced ear-canal noise in humans, but not through medial olivocochlear efferent inhibition: Implications for measuring otoacoustic emissions during behavioral task performance

• Downloaded 206 times
• Download rankings, all-time:
  • Site-wide: 100,819
  • In neuroscience: 15,760
• Year to date:
  • Site-wide: 117,882
• Since beginning of last month:
  • Site-wide: 93,077

Genetic and Epigenetic Intratumor Heterogeneity Impacts Prognosis of Lung Adenocarcinoma

• Downloaded 198 times
• Download rankings, all-time:
  • Site-wide: 102,611
  • In genetic and genomic medicine: 393
• Year to date:
  • Site-wide: 116,394
• Since beginning of last month:
  • Site-wide: 87,076

Modeling of histone modifications reveals formation mechanism and function of bivalent chromatin

• Downloaded 176 times
• Download rankings, all-time:
  • Site-wide: 107,154
  • In systems biology: 2,455
• Year to date:
  • Site-wide: 5,825
• Since beginning of last month:
  • Site-wide: 1,701

The human ApoE4 variant reduces functional recovery and neuronal sprouting after incomplete spinal cord injury in male mice

• Downloaded 162 times
• Download rankings, all-time:
  • Site-wide: 109,974
  • In neuroscience: 17,145
• Year to date:
  • Site-wide: 25,266
• Since beginning of last month:
  • Site-wide: 28,035

Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program

• Downloaded 148 times
• Download rankings, all-time:
  • Site-wide: 112,744
  • In genetic and genomic medicine: 488
• Year to date:
  • Site-wide: 7,409
• Since beginning of last month:
  • Site-wide: 15,347

Scaffold-scaffold interactions regulate cell polarity in a bacterium

• Downloaded 146 times
• Download rankings, all-time:
  • Site-wide: 113,046
  • In microbiology: 8,553
• Year to date:
  • Site-wide: 67,828
• Since beginning of last month:
  • Site-wide: 69,323

Discovering hidden brain network responses to naturalistic stimuli via tensor component analysis of multi-subject fMRI data

• Downloaded 138 times
• Download rankings, all-time:
  • Site-wide: 114,473
  • In neuroscience: 17,811
• Year to date:
  • Site-wide: 8,130
• Since beginning of last month:
  • Site-wide: 12,827

Dynamic Mechanical Cue Facilitate Collective Responses of Crowded Cell Population

• Downloaded 132 times
• Download rankings, all-time:
  • Site-wide: 115,690
  • In biophysics: 4,495
• Year to date:
  • Site-wide: 102,993
• Since beginning of last month:
  • Site-wide: 99,688