Author: Oleksandr Frei

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Preprints

Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model

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Genetics of brain age suggest an overlap with common brain disorders

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A global view of pleiotropy and genetic architecture in complex traits

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Estimating inflation in GWAS summary statistics due to variance distortion from cryptic relatedness

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Genome-wide association study of over 40,000 bipolar disorder cases provides novel biological insights

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Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation

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Linkage Disequilibrium and Heterozygosity Modulate the Genetic Architecture of Human Complex Phenotypes

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A genome-wide genetic pleiotropy approach identified shared loci between multiple system atrophy and inflammatory bowel disease

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The genetic architecture of human brainstem structures and their involvement in common brain disorders

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Brain scans from 21297 individuals reveal the genetic architecture of hippocampal subfield volumes

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Phenotypically independent mental health symptom profiles are genetically related

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Making the MOSTest of imaging genetics

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Cortico-genetic mapping links individual brain maturity in youths to cognitive and psychiatric traits

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Genome-wide association analysis of the human thalamus identifies novel genomic loci and reveals genetic overlap with distinct cortical regions and ten brain disorders

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Genetic control of variability in subcortical and intracranial volumes

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Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model

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Annotation-Informed Causal Mixture Modeling (AI-MiXeR) reveals phenotype-specific differences in polygenicity and effect size distribution across functional annotation categories

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Quantifying the polygenic architecture of the human cerebral cortex: Extensive genetic overlap between cortical thickness and surface area

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The genetic architecture of human cortical folding

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Multivariate genome-wide association study identifies 1735 unique genetic loci associated with cortical morphology.

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Improved prediction of schizophrenia by leveraging genetic overlap with brain morphology

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Population-based body-brain mapping links brain morphology and body composition

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Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank

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Fast qualitY conTrol meThod foR derIved diffUsion Metrics (YTTRIUM) in big data analysis: UK Biobank 18608 example

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Genetic overlap between Alzheimer's disease and depression mapped onto the brain

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