Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 70,616 bioRxiv papers from 308,309 authors.

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Preprints

Analysis of protein-coding genetic variation in 60,706 humans

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Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • In genetics: 14 out of 3,911
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Genomewide association study identifies 30 loci associated with bipolar disorder

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  • In genetics: 32 out of 3,911
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Common risk variants identified in autism spectrum disorder

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Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimers disease risk

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  • In genetics: 50 out of 3,911
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GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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  • In genetics: 52 out of 3,911
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Genome-wide Analysis of Insomnia (N=1,331,010) Identifies Novel Loci and Functional Pathways

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  • In genetics: 53 out of 3,911
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Regulatory variants explain much more heritability than coding variants across 11 common diseases

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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  • In genetics: 70 out of 3,911
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Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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  • In genomics: 217 out of 4,714
• Year to date:
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  • Site-wide: 243 out of 70,543

Genetic Identification Of Brain Cell Types Underlying Schizophrenia

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  • In genomics: 245 out of 4,714
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Psychiatric Genomics: An Update and an Agenda

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  • In genetics: 99 out of 3,911
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Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson’s Disease

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  • In genomics: 337 out of 4,714
• Year to date:
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  • Site-wide: 439 out of 70,543

Integrative approaches for large-scale transcriptome-wide association studies

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  • In genetics: 146 out of 3,911
• Year to date:
  • Site-wide: 46,283 out of 70,543
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  • Site-wide: 34,732 out of 70,543

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

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  • In genomics: 395 out of 4,714
• Year to date:
  • Site-wide: 54,365 out of 70,543
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  • Site-wide: 23,021 out of 70,543

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

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  • In genetics: 201 out of 3,911
• Year to date:
  • Site-wide: 59,178 out of 70,543
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  • Site-wide: 64,447 out of 70,543

GWAS Meta-Analysis of Neuroticism (N=449,484) Identifies Novel Genetic Loci and Pathways

• Downloaded 1,988 times
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  • Site-wide: 2,593 out of 70,543
  • In genetics: 239 out of 3,911
• Year to date:
  • Site-wide: 13,269 out of 70,543
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  • Site-wide: 19,466 out of 70,543

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

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  • In genetics: 253 out of 3,911
• Year to date:
  • Site-wide: 44,895 out of 70,543
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  • Site-wide: 32,220 out of 70,543

Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia

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  • In genomics: 601 out of 4,714
• Year to date:
  • Site-wide: 56,017 out of 70,543
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  • Site-wide: 27,350 out of 70,543

Comparative genetic architectures of schizophrenia in East Asian and European populations

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  • In genetics: 286 out of 3,911
• Year to date:
  • Site-wide: 4,173 out of 70,543
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  • Site-wide: 2,500 out of 70,543

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

• Downloaded 1,628 times
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  • In genetics: 309 out of 3,911
• Year to date:
  • Site-wide: 30,081 out of 70,543
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  • Site-wide: 39,326 out of 70,543

Human loss-of-function variants suggest that partial LRRK2 inhibition is a safe therapeutic strategy for Parkinson’s disease

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  • Site-wide: 4,305 out of 70,543
  • In genomics: 779 out of 4,714
• Year to date:
  • Site-wide: 6,881 out of 70,543
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  • Site-wide: 4,673 out of 70,543

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • In genomics: 903 out of 4,714
• Year to date:
  • Site-wide: 58,373 out of 70,543
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  • Site-wide: 22,916 out of 70,543

Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits

• Downloaded 1,296 times
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  • Site-wide: 5,357 out of 70,543
  • In genetics: 426 out of 3,911
• Year to date:
  • Site-wide: 15,644 out of 70,543
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  • Site-wide: 6,076 out of 70,543

Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders

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  • In genomics: 944 out of 4,714
• Year to date:
  • Site-wide: 20,019 out of 70,543
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  • Site-wide: 31,786 out of 70,543

Evaluation Of Chromatin Accessibility In Prefrontal Cortex Of Schizophrenia Cases And Controls

• Downloaded 1,039 times
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  • In genomics: 1,227 out of 4,714
• Year to date:
  • Site-wide: 62,970 out of 70,543
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  • Site-wide: 15,136 out of 70,543

Gene expression imputation across multiple brain regions reveals schizophrenia risk throughout development.

• Downloaded 960 times
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  • In genetics: 664 out of 3,911
• Year to date:
  • Site-wide: 30,017 out of 70,543
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  • Site-wide: 27,418 out of 70,543

Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

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  • In genetics: 676 out of 3,911
• Year to date:
  • Site-wide: 10,434 out of 70,543
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  • Site-wide: 41,197 out of 70,543

Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders

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  • In genomics: 1,410 out of 4,714
• Year to date:
  • Site-wide: 25,938 out of 70,543
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  • Site-wide: 49,534 out of 70,543

Functional consequences of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals

• Downloaded 897 times
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  • In genomics: 1,457 out of 4,714
• Year to date:
  • Site-wide: 54,129 out of 70,543
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  • Site-wide: 45,036 out of 70,543

Building a schizophrenia genetic network: Transcription Factor 4 regulates genes involved in neuronal development and schizophrenia risk.

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  • Site-wide: 10,786 out of 70,543
  • In genetics: 780 out of 3,911
• Year to date:
  • Site-wide: 32,893 out of 70,543
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  • Site-wide: 10,850 out of 70,543

Common Variant Associations with Fragile X Syndrome

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  • In genetics: 799 out of 3,911
• Year to date:
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  • Site-wide: 32,551 out of 70,543

Functional partitioning of local and distal gene expression regulation in multiple human tissues

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  • In genomics: 1,702 out of 4,714
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Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

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  • In genetics: 1,071 out of 3,911
• Year to date:
  • Site-wide: 8,983 out of 70,543
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  • Site-wide: 5,085 out of 70,543

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

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  • In genetics: 1,183 out of 3,911
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  • Site-wide: 59,471 out of 70,543

Integrative analysis of rare variants and pathway information shows convergent results between immune pathways, drug targets and epilepsy genes

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  • In genomics: 2,286 out of 4,714
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  • Site-wide: 30,702 out of 70,543

Robust Hi-C chromatin loop maps in human neurogenesis and brain tissues at high-resolution

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  • In genomics: 2,300 out of 4,714
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  • Site-wide: 5,862 out of 70,543

Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

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  • In genetics: 1,283 out of 3,911
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  • Site-wide: 42,470 out of 70,543

Reproducible Risk Loci and Psychiatric Comorbidities in Anxiety: Results from ~200,000 Million Veteran Program Participants

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  • In genetics: 1,335 out of 3,911
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  • Site-wide: 29,226 out of 70,543

Proof of concept: Molecular prediction of schizophrenia risk

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The Anorexia Nervosa Genetics Initiative: Overview and Methods

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  • Site-wide: 34,345 out of 70,543

Characterization of single gene copy number variants in schizophrenia

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  • In genetics: 2,098 out of 3,911
• Year to date:
  • Site-wide: 13,571 out of 70,543
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  • Site-wide: 26,772 out of 70,543

Genetic variation in the Major Histocompatibility Complex and association with depression

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  • In genetics: 2,264 out of 3,911
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  • Site-wide: 54,723 out of 70,543

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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  • In genetics: 2,451 out of 3,911
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  • Site-wide: 26,880 out of 70,543

Schizophrenia is characterized by age- and sex-specific effects on epigenetic aging

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  • Site-wide: 36,517 out of 70,543

Association Tests Using Copy Number Profile Curves (CONCUR) Enhances Power in Rare Copy Number Variant Analysis

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  • In bioinformatics: 5,456 out of 6,912
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mTADA: a framework for analyzing de novo mutations in multiple traits

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Antipsychotic behavioral phenotypes in the mouse Collaborative Cross recombinant inbred inter-crosses (RIX)

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