Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 62,198 bioRxiv papers from 276,129 authors.

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Preprints

Analysis of protein-coding genetic variation in 60,706 humans

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  • In genomics: 6 out of 4,277
• Year to date:
  • Site-wide: 3,218 out of 62,198
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  • Site-wide: 3,500 out of 62,198

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

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  • Site-wide: 134 out of 62,198
  • In genetics: 11 out of 3,537
• Year to date:
  • Site-wide: 533 out of 62,198
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  • Site-wide: 1,191 out of 62,198

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

• Downloaded 8,726 times
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  • Site-wide: 137 out of 62,198
  • In genetics: 13 out of 3,537
• Year to date:
  • Site-wide: 2,164 out of 62,198
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  • Site-wide: 5,929 out of 62,198

Genomewide association study identifies 30 loci associated with bipolar disorder

• Downloaded 5,966 times
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  • Site-wide: 294 out of 62,198
  • In genetics: 35 out of 3,537
• Year to date:
  • Site-wide: 311 out of 62,198
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  • Site-wide: 50,523 out of 62,198

Common risk variants identified in autism spectrum disorder

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  • Site-wide: 299 out of 62,198
  • In genetics: 37 out of 3,537
• Year to date:
  • Site-wide: 745 out of 62,198
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  • Site-wide: 2,037 out of 62,198

Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimers disease risk

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  • Site-wide: 470 out of 62,198
  • In genetics: 50 out of 3,537
• Year to date:
  • Site-wide: 1,973 out of 62,198
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  • Site-wide: 49,390 out of 62,198

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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  • Site-wide: 478 out of 62,198
  • In genetics: 51 out of 3,537
• Year to date:
  • Site-wide: 5,734 out of 62,198
• Since beginning of last month:
  • Site-wide: 5,638 out of 62,198

Genome-wide Analysis of Insomnia (N=1,331,010) Identifies Novel Loci and Functional Pathways

• Downloaded 4,447 times
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  • Site-wide: 497 out of 62,198
  • In genetics: 53 out of 3,537
• Year to date:
  • Site-wide: 1,858 out of 62,198
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  • Site-wide: 9,560 out of 62,198

Regulatory variants explain much more heritability than coding variants across 11 common diseases

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  • In genetics: 60 out of 3,537
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  • Site-wide: 15,427 out of 62,198

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

• Downloaded 3,684 times
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  • Site-wide: 724 out of 62,198
  • In genetics: 71 out of 3,537
• Year to date:
  • Site-wide: 409 out of 62,198
• Since beginning of last month:
  • Site-wide: 1,795 out of 62,198

Genetic Identification Of Brain Cell Types Underlying Schizophrenia

• Downloaded 3,332 times
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  • Site-wide: 871 out of 62,198
  • In genomics: 227 out of 4,277
• Year to date:
  • Site-wide: 4,954 out of 62,198
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  • Site-wide: 12,630 out of 62,198

Psychiatric Genomics: An Update and an Agenda

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  • In genetics: 92 out of 3,537
• Year to date:
  • Site-wide: 8,454 out of 62,198
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  • Site-wide: 8,719 out of 62,198

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

• Downloaded 2,893 times
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  • In genomics: 273 out of 4,277
• Year to date:
  • Site-wide: 182 out of 62,198
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  • Site-wide: 1,101 out of 62,198

Integrative approaches for large-scale transcriptome-wide association studies

• Downloaded 2,612 times
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  • Site-wide: 1,357 out of 62,198
  • In genetics: 132 out of 3,537
• Year to date:
  • Site-wide: 19,798 out of 62,198
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  • Site-wide: 21,175 out of 62,198

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

• Downloaded 2,375 times
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  • In genomics: 362 out of 4,277
• Year to date:
  • Site-wide: 21,886 out of 62,198
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  • Site-wide: None out of 62,198

Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

• Downloaded 2,264 times
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  • Site-wide: 1,754 out of 62,198
  • In genetics: 166 out of 3,537
• Year to date:
  • Site-wide: 22,516 out of 62,198
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  • Site-wide: 19,181 out of 62,198

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

• Downloaded 2,180 times
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  • Site-wide: 1,876 out of 62,198
  • In genetics: 180 out of 3,537
• Year to date:
  • Site-wide: 43,052 out of 62,198
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  • Site-wide: 37,790 out of 62,198

Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson's Disease

• Downloaded 2,118 times
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  • Site-wide: 1,986 out of 62,198
  • In genomics: 437 out of 4,277
• Year to date:
  • Site-wide: 330 out of 62,198
• Since beginning of last month:
  • Site-wide: 1,902 out of 62,198

GWAS Meta-Analysis of Neuroticism (N=449,484) Identifies Novel Genetic Loci and Pathways

• Downloaded 1,930 times
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  • Site-wide: 2,342 out of 62,198
  • In genetics: 222 out of 3,537
• Year to date:
  • Site-wide: 16,993 out of 62,198
• Since beginning of last month:
  • Site-wide: 14,468 out of 62,198

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

• Downloaded 1,854 times
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  • In genetics: 234 out of 3,537
• Year to date:
  • Site-wide: 26,047 out of 62,198
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  • Site-wide: 14,010 out of 62,198

Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia

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  • In genomics: 559 out of 4,277
• Year to date:
  • Site-wide: 35,903 out of 62,198
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  • Site-wide: None out of 62,198

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

• Downloaded 1,601 times
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  • Site-wide: 3,201 out of 62,198
  • In genetics: 284 out of 3,537
• Year to date:
  • Site-wide: 44,258 out of 62,198
• Since beginning of last month:
  • Site-wide: 33,259 out of 62,198

Comparative genetic architectures of schizophrenia in East Asian and European populations

• Downloaded 1,317 times
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  • Site-wide: 4,433 out of 62,198
  • In genetics: 373 out of 3,537
• Year to date:
  • Site-wide: 2,985 out of 62,198
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  • Site-wide: 2,911 out of 62,198

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

• Downloaded 1,276 times
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  • Site-wide: 4,651 out of 62,198
  • In genomics: 833 out of 4,277
• Year to date:
  • Site-wide: 18,258 out of 62,198
• Since beginning of last month:
  • Site-wide: 24,888 out of 62,198

Human loss-of-function variants suggest that partial LRRK2 inhibition is a safe therapeutic strategy for Parkinson’s disease

• Downloaded 1,245 times
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  • Site-wide: 4,846 out of 62,198
  • In genomics: 851 out of 4,277
• Year to date:
  • Site-wide: 934 out of 62,198
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  • Site-wide: 1,686 out of 62,198

Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders

• Downloaded 1,181 times
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  • Site-wide: 5,280 out of 62,198
  • In genomics: 906 out of 4,277
• Year to date:
  • Site-wide: 15,624 out of 62,198
• Since beginning of last month:
  • Site-wide: 8,990 out of 62,198

Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits

• Downloaded 1,119 times
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  • Site-wide: 5,793 out of 62,198
  • In genetics: 469 out of 3,537
• Year to date:
  • Site-wide: 2,359 out of 62,198
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  • Site-wide: 3,920 out of 62,198

Evaluation Of Chromatin Accessibility In Prefrontal Cortex Of Schizophrenia Cases And Controls

• Downloaded 984 times
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  • Site-wide: 7,126 out of 62,198
  • In genomics: 1,152 out of 4,277
• Year to date:
  • Site-wide: 39,477 out of 62,198
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  • Site-wide: 44,472 out of 62,198

Gene expression imputation across multiple brain regions reveals schizophrenia risk throughout development.

• Downloaded 901 times
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  • Site-wide: 8,216 out of 62,198
  • In genetics: 624 out of 3,537
• Year to date:
  • Site-wide: 12,410 out of 62,198
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  • Site-wide: 21,969 out of 62,198

Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders

• Downloaded 900 times
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  • Site-wide: 8,232 out of 62,198
  • In genomics: 1,282 out of 4,277
• Year to date:
  • Site-wide: 40,250 out of 62,198
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  • Site-wide: 35,476 out of 62,198

Functional consequences of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals

• Downloaded 874 times
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  • Site-wide: 8,603 out of 62,198
  • In genomics: 1,320 out of 4,277
• Year to date:
  • Site-wide: 36,049 out of 62,198
• Since beginning of last month:
  • Site-wide: 30,702 out of 62,198

Building a schizophrenia genetic network: Transcription Factor 4 regulates genes involved in neuronal development and schizophrenia risk.

• Downloaded 786 times
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  • Site-wide: 10,108 out of 62,198
  • In genetics: 742 out of 3,537
• Year to date:
  • Site-wide: 11,163 out of 62,198
• Since beginning of last month:
  • Site-wide: 17,698 out of 62,198

Common Variant Associations with Fragile X Syndrome

• Downloaded 781 times
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  • Site-wide: 10,202 out of 62,198
  • In genetics: 747 out of 3,537
• Year to date:
  • Site-wide: 15,922 out of 62,198
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  • Site-wide: 26,503 out of 62,198

Functional partitioning of local and distal gene expression regulation in multiple human tissues

• Downloaded 768 times
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  • Site-wide: 10,446 out of 62,198
  • In genomics: 1,521 out of 4,277
• Year to date:
  • Site-wide: 55,698 out of 62,198
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  • Site-wide: 47,532 out of 62,198

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

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  • Site-wide: 15,674 out of 62,198
  • In genetics: 1,080 out of 3,537
• Year to date:
  • Site-wide: 15,909 out of 62,198
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  • Site-wide: 18,484 out of 62,198

Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

• Downloaded 538 times
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  • Site-wide: 17,161 out of 62,198
  • In genetics: 1,167 out of 3,537
• Year to date:
  • Site-wide: 30,074 out of 62,198
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  • Site-wide: 26,744 out of 62,198

Integrative analysis of rare variants and pathway information shows convergent results between immune pathways, drug targets and epilepsy genes

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  • Site-wide: 18,763 out of 62,198
  • In genomics: 2,238 out of 4,277
• Year to date:
  • Site-wide: 18,974 out of 62,198
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  • Site-wide: 15,174 out of 62,198

Proof of concept: Molecular prediction of schizophrenia risk

• Downloaded 491 times
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  • Site-wide: 19,248 out of 62,198
  • In genomics: 2,268 out of 4,277
• Year to date:
  • Site-wide: 56,770 out of 62,198
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  • Site-wide: None out of 62,198

The Anorexia Nervosa Genetics Initiative: Overview and Methods

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  • In genetics: 1,374 out of 3,537
• Year to date:
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  • Site-wide: 14,693 out of 62,198

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

• Downloaded 465 times
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  • Site-wide: 20,538 out of 62,198
  • In genetics: 1,390 out of 3,537
• Year to date:
  • Site-wide: 5,212 out of 62,198
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  • Site-wide: 4,499 out of 62,198

Reproducible Risk Loci and Psychiatric Comorbidities in Anxiety: Results from ~200,000 Million Veteran Program Participants

• Downloaded 405 times
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  • In genetics: 1,585 out of 3,537
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  • Site-wide: 21,934 out of 62,198

Robust Hi-C chromatin loop maps in human neurogenesis and brain tissues at high-resolution

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  • In genomics: 2,680 out of 4,277
• Year to date:
  • Site-wide: 7,092 out of 62,198
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  • Site-wide: 1,976 out of 62,198

Genetic variation in the Major Histocompatibility Complex and association with depression

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  • Site-wide: 33,929 out of 62,198
  • In genetics: 2,141 out of 3,537
• Year to date:
  • Site-wide: 26,631 out of 62,198
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  • Site-wide: 35,822 out of 62,198

mTADA: a framework for analyzing de novo mutations in multiple traits

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  • Site-wide: 44,731 out of 62,198
  • In genomics: 3,673 out of 4,277
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  • Site-wide: 47,856 out of 62,198
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  • Site-wide: 27,883 out of 62,198

Association Tests Using Copy Number Profile Curves (CONCUR) Enhances Power in Rare Copy Number Variant Analysis

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  • Site-wide: 50,611 out of 62,198
  • In bioinformatics: 5,517 out of 6,210
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  • Site-wide: 27,667 out of 62,198
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  • Site-wide: 32,992 out of 62,198

Schizophrenia is characterized by age- and sex-specific effects on epigenetic aging

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  • In genomics: 3,974 out of 4,277
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  • Site-wide: 30,146 out of 62,198
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  • Site-wide: None out of 62,198